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Cancer Causes & Control
Published in: Cancer Causes & Control 8/2023

18-05-2023 | Obesity | Original Paper

Physical activity, obesity, and bladder cancer incidence

Authors: Sicha Chantaprasopsuk, Erika Rees-Punia, Alpa V. Patel

Published in: Cancer Causes & Control | Issue 8/2023

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Abstract

Purpose

Cigarette smoking is an established risk factor for bladder cancer (BC), but evidence for physical inactivity and obesity is limited.

Methods

This analysis included 146,027 participants from the Cancer Prevention Study-II (CPS-II) Nutrition Cohort, a large prospective cohort of cancer incidence established in 1992. Multivariable-adjusted Cox proportional hazards models were used to examine associations between body mass index (BMI), moderate-to-vigorous intensity aerobic physical activity (MVPA), leisure-time spent sitting, and BC risk. Effect modification by stage, smoking status, and sex was examined.

Results

Only participants accumulating 15.0- < 30.0 MET-hrs/wk of MVPA had a lower risk of BC overall (RR 0.88, 95% CI 0.78, 0.99, compared to > 0–7.5 MET-hrs/wk) in the fully adjusted models. When stratifying on BC stage, MVPA (15- < 30 MET-hrs/wk vs. > 0- < 7.5 MET-hrs/wk, RR 0.83, 95% CI 0.70–0.99) and excess sitting time (≥ 6 h/day vs. 0- < 3 h/day RR 1.22, 95% CI 1.02, 1.47) were associated with risk of invasive BC only. There was no consistent evidence for effect modification by smoking status or sex.

Conclusion

This study supports that MVPA and sitting time may play a role in BC incidence, but associations likely differ by stage at diagnosis. While additional studies are needed to confirm associations by stage, this study adds to the evidence of the importance of being physically active for cancer prevention.
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Metadata
Title
Physical activity, obesity, and bladder cancer incidence
Authors
Sicha Chantaprasopsuk
Erika Rees-Punia
Alpa V. Patel
Publication date
18-05-2023
Publisher
Springer International Publishing
Keywords
Obesity
Obesity
Published in
Cancer Causes & Control / Issue 8/2023
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-023-01711-0

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