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Published in: Osteoporosis International 4/2019

01-04-2019 | Obesity | Original Article

Obesity, bone density relative to body weight and prevalent vertebral fracture at age 62 years: the Newcastle thousand families study

Authors: H. A. Rudman, F. Birrell, M. S. Pearce, S. P. Tuck, R. M. Francis, L. Treadgold, K. Hind

Published in: Osteoporosis International | Issue 4/2019

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Abstract

Summary

Obesity increases the likelihood of prevalent vertebral fracture (VF) in men and women at age 62 years. The higher absolute bone mineral density (BMD) observed in obese individuals is disproportionate to body weight, and this may partly explain the greater prevalence of VF in this group.

Introduction

Obesity is a global epidemic, and there remains uncertainty over the effect of obesity on skeletal health, particularly in the context of osteoporosis. The aim of this study was to investigate associations of body mass index (BMI) and obesity with BMD and prevalent VF in men and women aged 62 years.

Methods

Three hundred and forty-two men and women aged 62.5 ± 0.5 years from the Newcastle Thousand Families Study birth cohort underwent DXA evaluations of femoral neck and lumbar spine BMD and of the lateral spine for vertebral fracture assessment.

Results

The likelihood of prevalent VF was significantly increased in men when compared to women (OR = 2.7, p < 0.001, 95% Cl 1.7–4.4). As BMI increased in women, so did the likelihood of prevalent any-grade VF (OR = 1.09, p = 0.006, 95% CI 1.02–1.17). Compared to normal weight women, obese women were more likely to have at least one VF (OR = 2.65, p = 0.025, CI 1.13–6.20) and at least one grade 1 vertebral deformity (OR = 4.39, p = 0.005, CI 1.57–12.28). Obese men were more likely to have a grade 2 and/or grade 3 VF compared to men of normal weight (OR = 3.36, p = 0.032, CI 1.11–10.16). In men and women, BMI was negatively associated with femoral neck BMD/weight (R = − 0.65, R = − 0.66, p < 0.001) and lumbar spine BMD/weight (R = − 0.66, R − 0.60, p < 0.001).

Conclusions

Obesity appears to be a risk factor for prevalent VF, and although absolute BMD is higher in obese individuals, this does not appear commensurate to their increased body weight.
Literature
3.
go back to reference NIH Consensus Development Panel on Osteoporosis Prevention, D. and Therapy (2001) Osteoporosis prevention, diagnosis, and therapy. JAMA 285(6):785–795CrossRef NIH Consensus Development Panel on Osteoporosis Prevention, D. and Therapy (2001) Osteoporosis prevention, diagnosis, and therapy. JAMA 285(6):785–795CrossRef
4.
go back to reference Ensrud KE, Schousboe JT (2011) Clinical practice. Vertebral fractures. N Engl J Med 364(17):1634–1642CrossRef Ensrud KE, Schousboe JT (2011) Clinical practice. Vertebral fractures. N Engl J Med 364(17):1634–1642CrossRef
5.
go back to reference Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359(9319):1761–1767CrossRef Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359(9319):1761–1767CrossRef
6.
go back to reference Hind K, Gannon L, Brightmore A, Beck B (2015) Insights into relationships between body mass, composition and bone: findings in elite rugby players. J Clin Densitom 18(2):172–178CrossRef Hind K, Gannon L, Brightmore A, Beck B (2015) Insights into relationships between body mass, composition and bone: findings in elite rugby players. J Clin Densitom 18(2):172–178CrossRef
7.
go back to reference Hernlund E, Svedbom A, Ivergard M, Compston J, Cooper C, Stenmark J, McCloskey EV, Jonsson B, Kanis JA (2013) Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the international Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos 8:136CrossRef Hernlund E, Svedbom A, Ivergard M, Compston J, Cooper C, Stenmark J, McCloskey EV, Jonsson B, Kanis JA (2013) Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the international Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos 8:136CrossRef
8.
go back to reference Roux C, Fechtenbaum J, Kolta S, Briot K, Girard M (2007) Mild prevalent and incident vertebral fractures are risk factors for new fractures. Osteoporos Int 18(12):1617–1624CrossRef Roux C, Fechtenbaum J, Kolta S, Briot K, Girard M (2007) Mild prevalent and incident vertebral fractures are risk factors for new fractures. Osteoporos Int 18(12):1617–1624CrossRef
9.
go back to reference European Prospective Osteoporosis Study, G, Felsenberg D, Silman AJ, Lunt M, Armbrecht G, Ismail AA, Finn JD, Cockerill WC, Banzer D, Benevolenskaya LI, Bhalla A, Bruges Armas J, Cannata JB, Cooper C, Dequeker J, Eastell R, Felsch B, Gowin W, Havelka S, Hoszowski K, Jajic I, Janott J, Johnell O, Kanis JA, Kragl G, Lopes Vaz A, Lorenc R, Lyritis G, Masaryk P, Matthis C, Miazgowski T, Parisi G, Pols HA, Poor G, Raspe HH, Reid DM, Reisinger W, Schedit-Nave C, Stepan JJ, Todd CJ, Weber K, Woolf AD, Yershova OB, Reeve J, O'Neill TW (2002) Incidence of vertebral fracture in europe: results from the European prospective osteoporosis study (EPOS). J Bone Miner Res 17(4):716–724CrossRef European Prospective Osteoporosis Study, G, Felsenberg D, Silman AJ, Lunt M, Armbrecht G, Ismail AA, Finn JD, Cockerill WC, Banzer D, Benevolenskaya LI, Bhalla A, Bruges Armas J, Cannata JB, Cooper C, Dequeker J, Eastell R, Felsch B, Gowin W, Havelka S, Hoszowski K, Jajic I, Janott J, Johnell O, Kanis JA, Kragl G, Lopes Vaz A, Lorenc R, Lyritis G, Masaryk P, Matthis C, Miazgowski T, Parisi G, Pols HA, Poor G, Raspe HH, Reid DM, Reisinger W, Schedit-Nave C, Stepan JJ, Todd CJ, Weber K, Woolf AD, Yershova OB, Reeve J, O'Neill TW (2002) Incidence of vertebral fracture in europe: results from the European prospective osteoporosis study (EPOS). J Bone Miner Res 17(4):716–724CrossRef
10.
go back to reference Curtis EM, van der Velde R, Moon RJ, van den Bergh JP, Geusens P, de Vries F, van Staa TP, Cooper C, Harvey NC (2016) Epidemiology of fractures in the United Kingdom 1988-2012: variation with age, sex, geography, ethnicity and socioeconomic status. Bone 87:19–26CrossRef Curtis EM, van der Velde R, Moon RJ, van den Bergh JP, Geusens P, de Vries F, van Staa TP, Cooper C, Harvey NC (2016) Epidemiology of fractures in the United Kingdom 1988-2012: variation with age, sex, geography, ethnicity and socioeconomic status. Bone 87:19–26CrossRef
11.
go back to reference Pirro M, Fabbriciani G, Leli C, Callarelli L, Manfredelli MR, Fioroni C, Mannarino MR, Scarponi AM, Mannarino E (2010) High weight or body mass index increase the risk of vertebral fractures in postmenopausal osteoporotic women. J Bone Miner Metab 28(1):88–93CrossRef Pirro M, Fabbriciani G, Leli C, Callarelli L, Manfredelli MR, Fioroni C, Mannarino MR, Scarponi AM, Mannarino E (2010) High weight or body mass index increase the risk of vertebral fractures in postmenopausal osteoporotic women. J Bone Miner Metab 28(1):88–93CrossRef
12.
go back to reference Felson DT, Zhang Y, Hannan MT, Anderson JJ (1993) Effects of weight and body mass index on bone mineral density in men and women: the Framingham study. J Bone Miner Res 8(5):567–573CrossRef Felson DT, Zhang Y, Hannan MT, Anderson JJ (1993) Effects of weight and body mass index on bone mineral density in men and women: the Framingham study. J Bone Miner Res 8(5):567–573CrossRef
13.
go back to reference Johnell O, Gullberg B, Kanis JA, Allander E, Elffors L, Dequeker J, Dilsen G, Gennari C, Lopes Vaz A, Lyritis G et al (1995) Risk factors for hip fracture in European women: the MEDOS study. Mediterranean osteoporosis study. J Bone Miner Res 10(11):1802–1815CrossRef Johnell O, Gullberg B, Kanis JA, Allander E, Elffors L, Dequeker J, Dilsen G, Gennari C, Lopes Vaz A, Lyritis G et al (1995) Risk factors for hip fracture in European women: the MEDOS study. Mediterranean osteoporosis study. J Bone Miner Res 10(11):1802–1815CrossRef
14.
go back to reference De Laet C, Kanis JA, Oden A, Johanson H, Johnell O, Delmas P, Eisman JA, Kroger H, Fujiwara S, Garnero P, McCloskey EV, Mellstrom D, Melton LJ 3rd, Meunier PJ, Pols HA, Reeve J, Silman A, Tenenhouse A (2005) Body mass index as a predictor of fracture risk: a meta-analysis. Osteoporos Int 16(11):1330–1338CrossRef De Laet C, Kanis JA, Oden A, Johanson H, Johnell O, Delmas P, Eisman JA, Kroger H, Fujiwara S, Garnero P, McCloskey EV, Mellstrom D, Melton LJ 3rd, Meunier PJ, Pols HA, Reeve J, Silman A, Tenenhouse A (2005) Body mass index as a predictor of fracture risk: a meta-analysis. Osteoporos Int 16(11):1330–1338CrossRef
15.
go back to reference Armstrong ME, Cairns BJ, Banks E, Green J, Reeves GK, Beral V (2012) Million women study, C. different effects of age, adiposity and physical activity on the risk of ankle, wrist and hip fractures in postmenopausal women. Bone 50(6):1394–1400CrossRef Armstrong ME, Cairns BJ, Banks E, Green J, Reeves GK, Beral V (2012) Million women study, C. different effects of age, adiposity and physical activity on the risk of ankle, wrist and hip fractures in postmenopausal women. Bone 50(6):1394–1400CrossRef
16.
go back to reference Compston JE, Watts NB, Chapurlat R, Cooper C, Boonen S, Greenspan S, Pfeilschifter J, Silverman S, Diez-Perez A, Lindsay R, Saag KG, Netelenbos JC, Gehlbach S, Hooven FH, Flahive J, Adachi JD, Rossini M, Lacroix AZ, Roux C, Sambrook PN, Siris ES, Glow I (2011) Obesity is not protective against fracture in postmenopausal women: GLOW. Am J Med 124(11):1043–1050CrossRef Compston JE, Watts NB, Chapurlat R, Cooper C, Boonen S, Greenspan S, Pfeilschifter J, Silverman S, Diez-Perez A, Lindsay R, Saag KG, Netelenbos JC, Gehlbach S, Hooven FH, Flahive J, Adachi JD, Rossini M, Lacroix AZ, Roux C, Sambrook PN, Siris ES, Glow I (2011) Obesity is not protective against fracture in postmenopausal women: GLOW. Am J Med 124(11):1043–1050CrossRef
17.
go back to reference Schousboe JT, Vokes T, Broy SB, Ferrar L, McKiernan F, Roux C, Binkley N (2008) Vertebral fracture assessment: the 2007 ISCD official positions. J Clin Densitom 11(1):92–108CrossRef Schousboe JT, Vokes T, Broy SB, Ferrar L, McKiernan F, Roux C, Binkley N (2008) Vertebral fracture assessment: the 2007 ISCD official positions. J Clin Densitom 11(1):92–108CrossRef
18.
go back to reference Ensrud KE, Blackwell TL, Fink HA, Zhang J, Cauley JA, Cawthon PM, Black DM, Bauer DC, Curtis JR, Orwoll ES, Barrett-Connor E, Kado DM, Marshall LM, Shikany JM, Schousboe JT (2016) Osteoporotic fractures in men research, G. what proportion of incident radiographic vertebral fractures in older men is clinically diagnosed and vice versa: a prospective study. J Bone Miner Res 31(8):1500–1503CrossRef Ensrud KE, Blackwell TL, Fink HA, Zhang J, Cauley JA, Cawthon PM, Black DM, Bauer DC, Curtis JR, Orwoll ES, Barrett-Connor E, Kado DM, Marshall LM, Shikany JM, Schousboe JT (2016) Osteoporotic fractures in men research, G. what proportion of incident radiographic vertebral fractures in older men is clinically diagnosed and vice versa: a prospective study. J Bone Miner Res 31(8):1500–1503CrossRef
19.
go back to reference Laslett LL, Just Nee Foley SJ, Quinn SJ, Winzenberg TM, Jones G (2012) Excess body fat is associated with higher risk of vertebral deformities in older women but not in men: a cross-sectional study. Osteoporos Int 23(1):67–74CrossRef Laslett LL, Just Nee Foley SJ, Quinn SJ, Winzenberg TM, Jones G (2012) Excess body fat is associated with higher risk of vertebral deformities in older women but not in men: a cross-sectional study. Osteoporos Int 23(1):67–74CrossRef
20.
go back to reference Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Yano S, Sugimoto T (2008) Combination of obesity with hyperglycemia is a risk factor for the presence of vertebral fractures in type 2 diabetic men. Calcif Tissue Int 83(5):324–331CrossRef Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Yano S, Sugimoto T (2008) Combination of obesity with hyperglycemia is a risk factor for the presence of vertebral fractures in type 2 diabetic men. Calcif Tissue Int 83(5):324–331CrossRef
21.
go back to reference Pearce MS, Unwin NC, Parker L, Craft AW (2009) Cohort profile: the Newcastle thousand families 1947 birth cohort. Int J Epidemiol 38(4):932–937CrossRef Pearce MS, Unwin NC, Parker L, Craft AW (2009) Cohort profile: the Newcastle thousand families 1947 birth cohort. Int J Epidemiol 38(4):932–937CrossRef
23.
go back to reference Hind K, Oldroyd B, Truscott JG (2010) In vivo precision of the GE lunar iDXA densitometer for the measurement of total-body, lumbar spine, and femoral bone mineral density in adults. J Clin Densitom 13(4):413–417CrossRef Hind K, Oldroyd B, Truscott JG (2010) In vivo precision of the GE lunar iDXA densitometer for the measurement of total-body, lumbar spine, and femoral bone mineral density in adults. J Clin Densitom 13(4):413–417CrossRef
24.
go back to reference Diacinti D, Del Fiacco R, Pisani D, Todde F, Cattaruzza MS, Diacinti D, Arima S, Romagnoli E, Pepe J, Cipriani C, Minisola S (2012) Diagnostic performance of vertebral fracture assessment by the lunar iDXA scanner compared to conventional radiography. Calcif Tissue Int 91(5):335–342CrossRef Diacinti D, Del Fiacco R, Pisani D, Todde F, Cattaruzza MS, Diacinti D, Arima S, Romagnoli E, Pepe J, Cipriani C, Minisola S (2012) Diagnostic performance of vertebral fracture assessment by the lunar iDXA scanner compared to conventional radiography. Calcif Tissue Int 91(5):335–342CrossRef
25.
go back to reference Genant HK, Li J, Wu CY, Shepherd JA (2000) Vertebral fractures in osteoporosis: a new method for clinical assessment. J Clin Densitom 3(3):281–290CrossRef Genant HK, Li J, Wu CY, Shepherd JA (2000) Vertebral fractures in osteoporosis: a new method for clinical assessment. J Clin Densitom 3(3):281–290CrossRef
26.
go back to reference Genant HK, Wu CY, van Kuijk C, Nevitt MC (1993) Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 8(9):1137–1148CrossRef Genant HK, Wu CY, van Kuijk C, Nevitt MC (1993) Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 8(9):1137–1148CrossRef
27.
go back to reference Kanis JA, Johnell O, Oden A, Johansson H, McCloskey EFRAX (2008) The assessment of fracture probability in men and women from the UK. Osteoporos Int 19(4):385–397CrossRef Kanis JA, Johnell O, Oden A, Johansson H, McCloskey EFRAX (2008) The assessment of fracture probability in men and women from the UK. Osteoporos Int 19(4):385–397CrossRef
28.
go back to reference Genant HK, Delmas PD, Chen P, Jiang Y, Eriksen EF, Dalsky GP, Marcus R, San Martin J (2007) Severity of vertebral fracture reflects deterioration of bone microarchitecture. Osteoporos Int 18(1):69–76CrossRef Genant HK, Delmas PD, Chen P, Jiang Y, Eriksen EF, Dalsky GP, Marcus R, San Martin J (2007) Severity of vertebral fracture reflects deterioration of bone microarchitecture. Osteoporos Int 18(1):69–76CrossRef
29.
go back to reference Cumming GP, Currie H, Morris E, Moncur R, Lee AJ (2015) The need to do better - are we still letting our patients down and at what cost? Post Reprod Health 21(2):56–62CrossRef Cumming GP, Currie H, Morris E, Moncur R, Lee AJ (2015) The need to do better - are we still letting our patients down and at what cost? Post Reprod Health 21(2):56–62CrossRef
30.
go back to reference Sornay-Rendu E, Cabrera-Bravo JL, Boutroy S, Munoz F, Delmas PD (2009) Severity of vertebral fractures is associated with alterations of cortical architecture in postmenopausal women. J Bone Miner Res 24(4):737–743CrossRef Sornay-Rendu E, Cabrera-Bravo JL, Boutroy S, Munoz F, Delmas PD (2009) Severity of vertebral fractures is associated with alterations of cortical architecture in postmenopausal women. J Bone Miner Res 24(4):737–743CrossRef
31.
go back to reference Delmas PD, Genant HK, Crans GG, Stock JL, Wong M, Siris E, Adachi JD (2003) Severity of prevalent vertebral fractures and the risk of subsequent vertebral and nonvertebral fractures: results from the MORE trial. Bone 33(4):522–532CrossRef Delmas PD, Genant HK, Crans GG, Stock JL, Wong M, Siris E, Adachi JD (2003) Severity of prevalent vertebral fractures and the risk of subsequent vertebral and nonvertebral fractures: results from the MORE trial. Bone 33(4):522–532CrossRef
32.
go back to reference Szulc P, Varennes A, Delmas PD, Goudable J, Chapurlat R (2010) Men with metabolic syndrome have lower bone mineral density but lower fracture risk--the MINOS study. J Bone Miner Res 25(6):1446–1454CrossRef Szulc P, Varennes A, Delmas PD, Goudable J, Chapurlat R (2010) Men with metabolic syndrome have lower bone mineral density but lower fracture risk--the MINOS study. J Bone Miner Res 25(6):1446–1454CrossRef
33.
go back to reference Hind K, Pearce M, Birrell F (2017) Total and visceral adiposity are associated with prevalent vertebral fracture in women but not men at age 62 years: the Newcastle thousand families study. J Bone Miner Res 32(5):1109–1115CrossRef Hind K, Pearce M, Birrell F (2017) Total and visceral adiposity are associated with prevalent vertebral fracture in women but not men at age 62 years: the Newcastle thousand families study. J Bone Miner Res 32(5):1109–1115CrossRef
34.
go back to reference Scane AC, Francis RM, Sutcliffe AM, Francis MJ, Rawlings DJ, Chapple CL (1999) Case-control study of the pathogenesis and sequelae of symptomatic vertebral fractures in men. Osteoporos Int 9(1):91–97CrossRef Scane AC, Francis RM, Sutcliffe AM, Francis MJ, Rawlings DJ, Chapple CL (1999) Case-control study of the pathogenesis and sequelae of symptomatic vertebral fractures in men. Osteoporos Int 9(1):91–97CrossRef
35.
go back to reference Compston JE, Flahive J, Hosmer DW, Watts NB, Siris ES, Silverman S, Saag KG, Roux C, Rossini M, Pfeilschifter J, Nieves JW, Netelenbos JC, March L, LaCroix AZ, Hooven FH, Greenspan SL, Gehlbach SH, Diez-Perez A, Cooper C, Chapurlat RD, Boonen S, Anderson FA Jr, Adami S, Adachi JD, Investigators G (2014) Relationship of weight, height, and body mass index with fracture risk at different sites in postmenopausal women: the global longitudinal study of osteoporosis in women (GLOW). J Bone Miner Res 29(2):487–493CrossRef Compston JE, Flahive J, Hosmer DW, Watts NB, Siris ES, Silverman S, Saag KG, Roux C, Rossini M, Pfeilschifter J, Nieves JW, Netelenbos JC, March L, LaCroix AZ, Hooven FH, Greenspan SL, Gehlbach SH, Diez-Perez A, Cooper C, Chapurlat RD, Boonen S, Anderson FA Jr, Adami S, Adachi JD, Investigators G (2014) Relationship of weight, height, and body mass index with fracture risk at different sites in postmenopausal women: the global longitudinal study of osteoporosis in women (GLOW). J Bone Miner Res 29(2):487–493CrossRef
36.
go back to reference Holmberg AH, Johnell O, Nilsson PM, Nilsson J, Berglund G, Akesson K (2006) Risk factors for fragility fracture in middle age. A prospective population-based study of 33,000 men and women. Osteoporos Int 17(7):1065–1077CrossRef Holmberg AH, Johnell O, Nilsson PM, Nilsson J, Berglund G, Akesson K (2006) Risk factors for fragility fracture in middle age. A prospective population-based study of 33,000 men and women. Osteoporos Int 17(7):1065–1077CrossRef
37.
go back to reference Tanaka S, Kuroda T, Saito M, Shiraki M (2013) Overweight/obesity and underweight are both risk factors for osteoporotic fractures at different sites in Japanese postmenopausal women. Osteoporos Int 24(1):69–76CrossRef Tanaka S, Kuroda T, Saito M, Shiraki M (2013) Overweight/obesity and underweight are both risk factors for osteoporotic fractures at different sites in Japanese postmenopausal women. Osteoporos Int 24(1):69–76CrossRef
38.
go back to reference Teasdale N, Simoneau M, Corbeil P, Handrigan G, Tremblay A, Hue O (2013) Obesity alters balance and movement control. Curr Obes Rep 2(3):235–240CrossRef Teasdale N, Simoneau M, Corbeil P, Handrigan G, Tremblay A, Hue O (2013) Obesity alters balance and movement control. Curr Obes Rep 2(3):235–240CrossRef
39.
go back to reference Hue O, Simoneau M, Marcotte J, Berrigan F, Dore J, Marceau P, Marceau S, Tremblay A, Teasdale N (2007) Body weight is a strong predictor of postural stability. Gait Post 26(1):32–38CrossRef Hue O, Simoneau M, Marcotte J, Berrigan F, Dore J, Marceau P, Marceau S, Tremblay A, Teasdale N (2007) Body weight is a strong predictor of postural stability. Gait Post 26(1):32–38CrossRef
40.
go back to reference Corbeil P, Simoneau M, Rancourt D, Tremblay A, Teasdale N (2001) Increased risk for falling associated with obesity: mathematical modeling of postural control. IEEE Trans Neural Syst Rehabil Eng 9(2):126–136CrossRef Corbeil P, Simoneau M, Rancourt D, Tremblay A, Teasdale N (2001) Increased risk for falling associated with obesity: mathematical modeling of postural control. IEEE Trans Neural Syst Rehabil Eng 9(2):126–136CrossRef
41.
go back to reference Pollintine P, Luo J, Offa-Jones B, Dolan P, Adams MA (2009) Bone creep can cause progressive vertebral deformity. Bone 45(3):466–472CrossRef Pollintine P, Luo J, Offa-Jones B, Dolan P, Adams MA (2009) Bone creep can cause progressive vertebral deformity. Bone 45(3):466–472CrossRef
42.
go back to reference Zhao LJ, Jiang H, Papasian CJ, Maulik D, Drees B, Hamilton J, Deng HW (2008) Correlation of obesity and osteoporosis: effect of fat mass on the determination of osteoporosis. J Bone Miner Res 23(1):17–29CrossRef Zhao LJ, Jiang H, Papasian CJ, Maulik D, Drees B, Hamilton J, Deng HW (2008) Correlation of obesity and osteoporosis: effect of fat mass on the determination of osteoporosis. J Bone Miner Res 23(1):17–29CrossRef
43.
go back to reference Sornay-Rendu E, Boutroy S, Vilayphiou N, Claustrat B, Chapurlat RD (2013) In obese postmenopausal women, bone microarchitecture and strength are not commensurate to greater body weight: the Os des femmes de Lyon (OFELY) study. J Bone Miner Res 28(7):1679–1687CrossRef Sornay-Rendu E, Boutroy S, Vilayphiou N, Claustrat B, Chapurlat RD (2013) In obese postmenopausal women, bone microarchitecture and strength are not commensurate to greater body weight: the Os des femmes de Lyon (OFELY) study. J Bone Miner Res 28(7):1679–1687CrossRef
44.
go back to reference Beck TJ, Petit MA, Wu G, LeBoff MS, Cauley JA, Chen Z (2009) Does obesity really make the femur stronger? BMD, geometry, and fracture incidence in the women's health initiative-observational study. J Bone Miner Res 24(8):1369–1379CrossRef Beck TJ, Petit MA, Wu G, LeBoff MS, Cauley JA, Chen Z (2009) Does obesity really make the femur stronger? BMD, geometry, and fracture incidence in the women's health initiative-observational study. J Bone Miner Res 24(8):1369–1379CrossRef
45.
go back to reference Donaldson MG, Palermo L, Schousboe JT, Ensrud KE, Hochberg MC, Cummings SRFRAX (2009) Risk of vertebral fractures: the fracture intervention trial. J Bone Miner Res 24(11):1793–1799CrossRef Donaldson MG, Palermo L, Schousboe JT, Ensrud KE, Hochberg MC, Cummings SRFRAX (2009) Risk of vertebral fractures: the fracture intervention trial. J Bone Miner Res 24(11):1793–1799CrossRef
Metadata
Title
Obesity, bone density relative to body weight and prevalent vertebral fracture at age 62 years: the Newcastle thousand families study
Authors
H. A. Rudman
F. Birrell
M. S. Pearce
S. P. Tuck
R. M. Francis
L. Treadgold
K. Hind
Publication date
01-04-2019
Publisher
Springer London
Keywords
Obesity
Obesity
Published in
Osteoporosis International / Issue 4/2019
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-018-04817-3

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