Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Obesity Surgery
Published in: Obesity Surgery 6/2020

01-06-2020 | Obesity | Brief Communication

Evaluation of Heart Rate Variability and Endothelial Function 3 Months After Bariatric Surgery

Authors: Tassia Gomide Braga, Maria das Graças Coelho de Souza, Priscila Alves Maranhão, Michel Menezes, Ludmilla Dellatorre-Teixeira, Eliete Bouskela, Carel W. Le Roux, Luiz Guilherme Kraemer-Aguiar

Published in: Obesity Surgery | Issue 6/2020

Login to get access

Abstract

We investigated endothelial and autonomic nervous functions after bariatric surgery. For this, we prospectively recruited 40 patients for bariatric surgery or medical treatment (20 in each group). Heart rate variability (HRV) and endothelial function were evaluated before and 3 months after treatments. Glucagon-like peptide 1 (GLP-1), insulin, and glucose at fasting and 30 and 60 min after a standard 300-kcal meal were also analyzed. Surgery but not medical care increased HRV in all time-domain variables, while frequency-domain variables, vascular elasticity, and endothelial reactivity did not change. Changes in GLP-1 and insulin resistance markers did not correlate with HRV. After 3 months, bariatric surgery improved the parasympathetic activity of cardiac autonomic function. Trial registration: NCT03911479
Literature
1.
Taylor JA, Carr DL, Myers CW, et al. Mechanisms underlying very-low-frequency RR-interval oscillations in humans. Circulation. 1998;98(6):547–55.CrossRef
2.
Maser RE, Lenhard MJ, Irgau I, et al. Impact of surgically induced weight loss on cardiovascular autonomic function: one-year follow-up. Obesity (Silver Spring). 2007;15(2):364–9.CrossRef
3.
Illan Gomez F, Gonzalvez Ortega M, Aragon Alonso A, et al. Obesity, endothelial function and inflammation: the effects of weight loss after bariatric surgery. Nutr Hosp. 2016;33(6):1340–6.CrossRef
4.
Goldstone AP, Miras AD, Scholtz S, et al. Link between increased satiety gut hormones and reduced food reward after gastric bypass surgery for obesity. J Clin Endocrinol Metab. 2016;101(2):599–609.CrossRef
5.
Basu A, Charkoudian N, Schrage W, et al. Beneficial effects of GLP-1 on endothelial function in humans: dampening by glyburide but not by glimepiride. Am J Physiol Endocrinol Metab. 2007;293(5):E1289–95.CrossRef
6.
De Luca M, Angrisani L, Himpens J, et al. Indications for surgery for obesity and weight-related diseases: position statements from the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO). Obes Surg. 2016;26(8):1659–96.CrossRef
7.
Li Y, Yang Y, Wang W, et al. Peripheral arterial stiffness is correlated with intrarenal arteriolosclerosis according to biopsies from patients with kidney disease. Nephrology (Carlton). 2019;
8.
Farinatti P, Neto SR, Dias I, et al. Short-term resistance training attenuates cardiac autonomic dysfunction in obese adolescents. Pediatr Exerc Sci. 2016;28(3):374–80.CrossRef
9.
Griffioen KJ, Wan R, Okun E, et al. GLP-1 receptor stimulation depresses heart rate variability and inhibits neurotransmission to cardiac vagal neurons. Cardiovasc Res. 2011;89(1):72–8.CrossRef
10.
Petersen KS, Clifton PM, Lister N, et al. Effect of weight loss induced by energy restriction on measures of arterial compliance: a systematic review and meta-analysis. Atherosclerosis. 2016;247:7–20.CrossRef
Metadata
Title
Evaluation of Heart Rate Variability and Endothelial Function 3 Months After Bariatric Surgery
Authors
Tassia Gomide Braga
Maria das Graças Coelho de Souza
Priscila Alves Maranhão
Michel Menezes
Ludmilla Dellatorre-Teixeira
Eliete Bouskela
Carel W. Le Roux
Luiz Guilherme Kraemer-Aguiar
Publication date
01-06-2020
Publisher
Springer US
Published in
Obesity Surgery / Issue 6/2020
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-020-04397-4

Other articles of this Issue 6/2020

Obesity Surgery 6/2020 Go to the issue

Brief Communication

Does Colectomy Improve Type 2 Diabetes?

Brief Communication

Sleep Duration and Timing in the Medium- to Long-Term Post-Bariatric Surgery

Original Contributions

Positive and Negative Independent Predictive Factors of Weight Loss After Bariatric Surgery in a Veteran Population

Original Contributions

Determinants of High Parathyroid Hormone Levels in Patients With Severe Obesity and Their Relationship With the Cardiometabolic Risk Factors, Before and After a Laparoscopic Sleeve Gastrectomy Intervention

Original Contributions

Association Between Surgeon Practice Knowledge and Venous Thromboembolism

Letter to the Editor

Quantifying Thyroid Hormone Resistance in Obesity