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01-08-2020 | Obesity | Original Article

Changes in Gut Microbiota Composition after Bariatric Surgery: a New Balance to Decode

Authors: Silvia Palmisano, Giuseppina Campisciano, Marta Silvestri, Martina Guerra, Michela Giuricin, Biagio Casagranda, Manola Comar, Nicolò de Manzini

Published in: Journal of Gastrointestinal Surgery | Issue 8/2020

Abstract

Background

Recently, the link between obesity and gut microbiota has become a focus for research. This study shed some light on the modification of postoperative gut microbial composition after bariatric surgery.

Methods

A prospective longitudinal study on healthy lean subjects and patients who underwent bariatric surgery (Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy) was carried out. Anthropometric and metabolic data, smoking, food preferences data, and stool samples were collected from lean subjects and from obese patients before and 3 and 6 months after surgery (T0, T3, and T6, respectively).

Results

We collected stool samples from 25 obese patients before surgery and 3 and 6 months thereafter and from 25 normal weight patients. After Roux-en-Y gastric bypass, Yokenella regensburgei (p < 0.05), Fusobacterium varium (p < 0.05), Veillonella dispar/atypica (p < 0.05), and Streptococcus australis/gordonii (p < 0.05) were transiently identified in the gut at T3. Roux-en-Y gastric bypass patients had a permanent increase in Akkermansia muciniphila (p < 0.05), which is associated with healthy metabolism, both at T3 and T6. There were no significant changes in gut microbiota in laparoscopic sleeve gastrectomy patients.

Conclusions

In our study, Roux-en-Y gastric bypass induced major microbial differences and greater weight loss compared with laparoscopic sleeve gastrectomy. Analyzing the microbiota composition, a proliferation of potential pathogens and the onset of beneficial bacteria was observed. The effects of these bacteria on human health are still far from clear. Understanding the mechanisms of action of these bacteria could be the keystone in developing new therapeutic strategies for obesity.

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Title: Changes in Gut Microbiota Composition after Bariatric Surgery: a New Balance to Decode
Authors: Silvia Palmisano
Giuseppina Campisciano
Marta Silvestri
Martina Guerra
Michela Giuricin
Biagio Casagranda
Manola Comar
Nicolò de Manzini
Publication date: 01-08-2020
Publisher: Springer US
Keywords: Obesity
Obesity
Bariatric Surgery
Streptococci
Bariatric Surgery
Respiratory Microbiota
Published in: Journal of Gastrointestinal Surgery / Issue 8/2020
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-019-04321-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Changes in Gut Microbiota Composition after Bariatric Surgery: a New Balance to Decode

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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