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Reproductive Biology and Endocrinology
Published in: Reproductive Biology and Endocrinology 1/2020

01-12-2020 | Obesity | Research

Association between obesity-associated markers and semen quality parameters and serum reproductive hormones in Chinese infertile men

Authors: Jian-Xiong Ma, Bin Wang, Hai-Song Li, Xue-Juan Jiang, Jia Yu, Cai-Fei Ding, Wang-Qiang Chen

Published in: Reproductive Biology and Endocrinology | Issue 1/2020

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Abstract

Background

The current evidence on the association between obesity-associated markers and semen quality, serum reproductive hormones and lipids remains inconsistent. In this study, we tested the hypothesis that, in infertile Chinese men, body mass index (BMI) negatively correlates with sperm concentration, serum total testosterone (TT), and high-density lipoprotein cholesterol (HDL-C). The relationship between other obesity-associated markers and semen quality parameters, serum reproductive hormones, lipids and leptin were also investigated.

Methods

181 Chinese infertile men were recruited from September 2018 to September 2019. Their obesity-associated markers, semen parameters, and serum reproductive hormones, lipids and leptin were detected. Statistical analysis was performed to assess the relationship between obesity-associated markers and semen quality, serum reproductive hormones, lipids and leptin.

Result(s)

Statistically negative correlation was found between other obesity-associated markers (e.g. waist-to-hip ratio and waist-to-height ratio) and semen parameters (e.g. sperm concentration, ratio of progressive motility and ratio of non-progressive motility), while no significant correlation was found between BMI and semen quality, serum reproductive hormones, lipids and leptin. Ratio of morphologically normal sperm was negatively correlated with serum lipids including total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), leptin and seminal superoxide dismutase. Ratio of progressive sperm, sperm concentration and ratio of morphologically normal sperm exhibited significantly lower values in overweight group than normal group. Estradiol (E2) and E2/TT were significantly higher in obese group than normal group, while TT level was significantly lower in obese group than normal group. Univariate and multivariate analysis indicated that TC was significantly associated with BMI. Serum leptin concentration was positively correlated with seminal leptin concentration in overweight and obese groups.

Conclusion(s)

No significant correlation was found between BMI and sperm concentration, serum TT and HDL-C, while other obesity-associated markers were found to negatively correlate with sperm concentration, ratio of progressive motility and ratio of non-progressive motility. Statistically significant correlations between serum reproductive hormones, lipids and leptin also existed in Chinese infertile men.
Appendix
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Literature
1.
Chavarro JE, et al. Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic. Fertil Steril. 2010;93(7):2222–31.PubMedCrossRef
2.
Shen DC, et al. Comparison of the effects of differences in ratio of waist to hip girth and body mass index on carbohydrate metabolism in Chinese females. Horm Metab Res. 1990;22(10):533–6.PubMedCrossRef
3.
Visscher TL, et al. A comparison of body mass index, waist-hip ratio and waist circumference as predictors of all-cause mortality among the elderly: the Rotterdam study. Int J Obes Relat Metab Disord. 2001;25(11):1730–5.PubMedCrossRef
4.
Feldstein CA, et al. A comparison of body mass index and waist-to-hip ratio as indicators of hypertension risk in an urban argentine population: a hospital-based study. Nutr Metab Cardiovasc Dis. 2005;15(4):310–5.PubMedCrossRef
5.
Nyamdorj R, et al. Comparison of body mass index with waist circumference, waist-to-hip ratio, and waist-to-stature ratio as a predictor of hypertension incidence in Mauritius. J Hypertens. 2008;26(5):866–70.PubMedCrossRef
6.
7.
Vander Borght M. And C. Wyns, Fertility and infertility: Definition and epidemiology. Clin Biochem. 2018;62:2–10.PubMedCrossRef
8.
MacDonald AA, et al. The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis. Hum Reprod Update. 2010;16(3):293–311.PubMedCrossRef
9.
Sallmen M, et al. Reduced fertility among overweight and obese men. Epidemiology. 2006;17(5):520–3.CrossRefPubMed
10.
11.
Ramlau-Hansen CH, et al. Subfecundity in overweight and obese couples. Hum Reprod. 2007;22(6):1634–7.PubMedCrossRef
12.
Belloc S, et al. High body mass index has a deleterious effect on semen parameters except morphology: results from a large cohort study. Fertil Steril. 2014;102(5):1268–73.PubMedCrossRef
13.
Lu JC, et al. Body mass index, waist-to-hip ratio, waist circumference and waist-to-height ratio cannot predict male semen quality: a report of 1231 subfertile Chinese men. Andrologia. 2015;47(9):1047–54.PubMedCrossRef
14.
Aggerholm AS, et al. Is overweight a risk factor for reduced semen quality and altered serum sex hormone profile? Fertil Steril. 2008;90(3):619–26.PubMedCrossRef
15.
Kaufman JM, Vermeulen A. The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr Rev. 2005;26(6):833–76.PubMedCrossRef
16.
Hammoud AO, et al. Impact of male obesity on infertility: a critical review of the current literature. Fertil Steril. 2008;90(4):897–904.PubMedCrossRef
17.
Campfield LA, Smith FJ, Burn P. The OB protein (leptin) pathway--a link between adipose tissue mass and central neural networks. Horm Metab Res. 1996;28(12):619–32.PubMedCrossRef
18.
19.
Steinman N, et al. Serum leptin concentrations are higher in azoospermic than in normozoospermic men. Fertil Steril. 2001;75(4):821–2.PubMedCrossRef
20.
von Sobbe HU, et al. Leptin concentrations in semen are correlated with serum leptin and elevated in hypergonadotrophic hypogonadism. Andrologia. 2003;35(4):233–7.CrossRef
21.
22.
Lu JC, et al. Analysis of human sperm DNA fragmentation index (DFI) related factors: a report of 1010 subfertile men in China. Reprod Biol Endocrinol. 2018;16(1):23.PubMedPubMedCentralCrossRef
23.
Organization, W.H. WHO Laboratory manual for the examination and processing of human semen. 5th ed; 2010.
24.
Menkveld R, et al. The evaluation of morphological characteristics of human spermatozoa according to stricter criteria. Hum Reprod. 1990;5(5):586–92.PubMedCrossRef
25.
Organization, W.H. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. 2000;894(i-xii):1–253.
26.
Zhou BF, C. Cooperative Meta-Analysis Group of the Working Group on obesity in, Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Biomed Environ Sci. 2002;15(1):83–96.PubMed
27.
Jia WP, et al. Prediction of abdominal visceral obesity from body mass index, waist circumference and waist-hip ratio in Chinese adults: receiver operating characteristic curves analysis. Biomed Environ Sci. 2003;16(3):206–11.PubMed
28.
Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15(7):539–53.PubMedCrossRef
29.
Raman R, et al. Association of obesity with diabetic retinopathy: Sankara Nethralaya diabetic retinopathy epidemiology and molecular genetics study (SN-DREAMS report no. 8). Acta Diabetol. 2010;47(3):209–15.PubMedCrossRef
30.
31.
Cooper TG, et al. World Health Organization reference values for human semen characteristics. Hum Reprod Update. 2010;16(3):231–45.PubMedCrossRef
32.
Paasch U, et al. Obesity and age affect male fertility potential. Fertil Steril. 2010;94(7):2898–901.PubMedCrossRef
33.
Jensen TK, et al. Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertil Steril. 2004;82(4):863–70.PubMedCrossRef
34.
Koloszar S, et al. Effect of body weight on sperm concentration in normozoospermic males. Arch Androl. 2005;51(4):299–304.PubMedCrossRef
35.
Magnusdottir EV, et al. Persistent organochlorines, sedentary occupation, obesity and human male subfertility. Hum Reprod. 2005;20(1):208–15.PubMedCrossRef
36.
Kort HI, et al. Impact of body mass index values on sperm quantity and quality. J Androl. 2006;27(3):450–2.PubMedCrossRef
37.
Eskandar M, et al. Impact of male obesity on semen quality and serum sex hormones. Ther Adv Urol. 2012;2012:407601.
38.
Fejes I, et al. Is semen quality affected by male body fat distribution? Andrologia. 2005;37(5):155–9.PubMedCrossRef
39.
Cazzaniga W, et al. The impact of metabolically healthy obesity in primary infertile men: results from a cross-sectional study. Andrology. 2020.
40.
B, M.A.-A, et al. Body mass index has no impact on sperm quality but on reproductive hormones levels. Andrologia. 2014;46(2):106–11.CrossRef
41.
Zhang Q, et al. Assessment of seminal estradiol and testosterone levels as predictors of human spermatogenesis. J Androl. 2010;31(2):215–20.PubMedCrossRef
42.
Paul RF, et al. Effect of body mass index on serum leptin levels. J Ayub Med Coll Abbottabad. 2011;23(3):40–3.PubMed
43.
Al Maskari, M.Y. And A.A. Alnaqdy, Correlation between Serum Leptin Levels, Body Mass Index and Obesity in Omanis. Sultan Qaboos Univ Med J, 2006. 6(2): p. 27–31.
44.
Li HW, et al. Effect of leptin on motility, capacitation and acrosome reaction of human spermatozoa. Int J Androl. 2009;32(6):687–94.PubMedCrossRef
45.
Guo J, et al. Sperm motility inversely correlates with seminal leptin levels in idiopathic asthenozoospermia. Int J Clin Exp Med. 2014;7(10):3550–5.PubMedPubMedCentral
46.
Abbasihormozi S, et al. Relationship of leptin administration with production of reactive oxygen species, sperm DNA fragmentation, sperm parameters and hormone profile in the adult rat. Arch Gynecol Obstet. 2013;287(6):1241–9.PubMedCrossRef
47.
Behre HM, Simoni M, Nieschlag E. Strong association between serum levels of leptin and testosterone in men. Clin Endocrinol. 1997;47(2):237–40.CrossRef
Metadata
Title
Association between obesity-associated markers and semen quality parameters and serum reproductive hormones in Chinese infertile men
Authors
Jian-Xiong Ma
Bin Wang
Hai-Song Li
Xue-Juan Jiang
Jia Yu
Cai-Fei Ding
Wang-Qiang Chen
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Reproductive Biology and Endocrinology / Issue 1/2020
Electronic ISSN: 1477-7827
DOI
https://doi.org/10.1186/s12958-020-00652-6

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