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Open Access 01-12-2022 | Obesity | Research

Association between nutrient patterns and hyperuricemia: mediation analysis involving obesity indicators in the NHANES

Authors: Juping Wang, Shuting Chen, Junkang Zhao, Jie Liang, Xue Gao, Qian Gao, Simin He, Tong Wang

Published in: BMC Public Health | Issue 1/2022

Abstract

Background

Diet has long been hypothesized to play an important role in hyperuricemia, and weight gain is a factor that is strongly associated with the rise in serum urate. We aimed to clarify the mediating role of obesity in the relationship between diet and hyperuricemia and to determine whether a weight-loss diet is an effective way to prevent hyperuricemia.

Methods

This cross-sectional study analysed representative samples of United States (n = 20,081; NHANES 2007–2016) adults. Nutrient patterns were derived with two methods: principal component analysis (PCA) and reduced rank regression (RRR) with obesity. Logistic regression and multivariable linear regression were applied to analyse the association between nutrient patterns in obesity and hyperuricemia. Mediation analyses were used to determine whether four obesity indicators, including body mass index (BMI), waist circumference (WC), visceral adiposity index (VAI) and lipid accumulation product index (LAP), mediated the relationship between nutrient patterns and hyperuricemia.

Results

PCA revealed three nutrient patterns (including “Low energy diet”, “Lower vitamin A, C, K pattern” and “Vitamin B group”), and only Vitamin B group had a total effect on hyperuricemia. RRR revealed one main nutrient pattern associated with obesity, which was characterized by High fat and low vitamin levels and was significantly associated with hyperuricemia. Mediation analysis showed that obesity mostly or even completely mediated the relationship between nutrient patterns and hyperuricemia, especially traditional obesity indicators, which played a key intermediary effect. The proportions of indirect effects for BMI and WC were as high as 53.34 and 59.69, respectively.

Conclusions

Our findings suggest that the direct effect of diet on hyperuricemia is weak, and obesity plays a critical mediating role in the relationship between diet and hyperuricemia, which confirms that a weight-loss diet such as a “Low fat and high vitamin diet” may be useful in preventing hyperuricemia.

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Title: Association between nutrient patterns and hyperuricemia: mediation analysis involving obesity indicators in the NHANES
Authors: Juping Wang
Shuting Chen
Junkang Zhao
Jie Liang
Xue Gao
Qian Gao
Simin He
Tong Wang
Publication date: 01-12-2022
Publisher: BioMed Central
Keywords: Obesity
Obesity
Published in: BMC Public Health / Issue 1/2022
Electronic ISSN: 1471-2458
DOI: https://doi.org/10.1186/s12889-022-14357-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association between nutrient patterns and hyperuricemia: mediation analysis involving obesity indicators in the NHANES

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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