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01-12-2022 | Obesity | Original Article

Association between metabolic syndrome and osteoporosis among adults aged 50 years and older: using the National Health Information Database in South Korea

Authors: Sang Youl Rhee, Dong Keon Yon, Mi Jung Kwon, Ji Hee Kim, Joo-Hee Kim, Woo Jin Bang, Jung Woo Lee, Bong-Cheol Kwon, Hyo Geun Choi, Chanyang Min

Published in: Archives of Osteoporosis | Issue 1/2022

Abstract

Summary

This study aimed to examine the association between a history of metabolic syndrome (MetS) and osteoporosis with specific characteristics. The results showed that MetS was inversely associated with osteoporosis. In contrast, MetS was positively associated with osteoporosis in both obese men and postmenopausal obese women.

Purpose

Although several previous studies have investigated the association between MetS and osteoporosis, their findings remain controversial. This study aimed to examine the association between a MetS history and osteoporosis using a subset of data from a large, long-term, national database.

Methods

This nested case–control study used the National Health Information Database (NHID) of the Korea National Health Insurance Service (NHIS) from 2009 to 2017. Osteoporosis (n = 459,771) and control (n = 459,771) participants were matched in a 1:1 ratio by age, gender, income, and region of residence. MetS was defined based on the modified National Cholesterol Education Program-Adult Treatment Panel III criteria. Crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs) for osteoporosis in patients with MetS and its components were analyzed using logistic regression. Subgroup analyses were performed according to the combination of gender, menopausal status, and obesity status.

Results

The adjusted OR (95% CI) for osteoporosis in patients with MetS was 0.95 (0.94–0.96). This finding was consistent with the subgroup analyses in normal weight men, premenopausal (pre-MP) women with all obesity statuses, and postmenopausal (post-MP) underweight and normal weight women. In contrast, the opposite was observed for obese men (OR = 1.05, 95% CI = 1.01–1.09) and post-MP obese women (OR = 1.05, 95% CI = 1.01–1.08).

Conclusion

This study results suggested that MetS was associated with a low occurrence of osteoporosis. In contrast, MetS was associated with a high occurrence of osteoporosis in both obese men and post-MP obese women.

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Title: Association between metabolic syndrome and osteoporosis among adults aged 50 years and older: using the National Health Information Database in South Korea
Authors: Sang Youl Rhee
Dong Keon Yon
Mi Jung Kwon
Ji Hee Kim
Joo-Hee Kim
Woo Jin Bang
Jung Woo Lee
Bong-Cheol Kwon
Hyo Geun Choi
Chanyang Min
Publication date: 01-12-2022
Publisher: Springer London
Keywords: Obesity
Obesity
Underweight
Osteoporosis
Underweight
Osteoporosis
Published in: Archives of Osteoporosis / Issue 1/2022
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI: https://doi.org/10.1007/s11657-022-01161-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association between metabolic syndrome and osteoporosis among adults aged 50 years and older: using the National Health Information Database in South Korea

Abstract

Summary

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Summary

Purpose

Methods

Results

Conclusion

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