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BMC Oral Health
Published in: BMC Oral Health 1/2023

Open Access 01-12-2023 | Obesity | Research

Association between C-Reactive protein and periodontitis in an obese population from the NHANES 2009–2010

Authors: Jiangling Sun, Wang Wang, Dongdong Li, Jukun Song, Zhu Chen, Liming Chen, Ralf Smeets, Thomas Beikler, Jan Strenge, Zhe Yang, Reinhard E. Friedrich

Published in: BMC Oral Health | Issue 1/2023

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Abstract

Background

Various data have been obtained on the relationship between body mass index (BMI) and C-reactive protein (CRP) and periodontitis. The aim of this study was to determine whether CRP/BMI are associated with periodontitis using data from the National Health and Nutrition Examination Survey (NHANES) database.

Methods

A cross-sectional analysis of data from 3602 participants in the 2009–2010 NHANES cycle was performed. The definition of periodontitis was used to divide participants into four groups according to the criteria of Eke. Correlations between CRP/BMI and periodontitis were tested for statistical significance by means of descriptive statistics, multivariate regression, and subgroup-stratified analyses, with and without adjustments for confounders (such as age and sex).

Results

There were no statistically significant differences (p > 0.05) regarding BMI and the development of periodontitis. After adjustment for age, sex, race, marital status, annual family income, alcohol consumption, hypertension, smoking, chronic pulmonary disease, cardiovascular disease, diabetes, flossing, and arthritis, CRP correlated significantly with the development of periodontitis in the subgroups stratified by obesity, with an odds ratio (OR) of 1.2 (95% CI, 1.0 to 1.5).

Conclusion

Through data analysis, we found an association between CRP levels and periodontitis prevalence in the American population, although this association was only present in the obese population. While there are several hypotheses about the underlying mechanism, further studies are needed to validate these findings.
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Metadata
Title
Association between C-Reactive protein and periodontitis in an obese population from the NHANES 2009–2010
Authors
Jiangling Sun
Wang Wang
Dongdong Li
Jukun Song
Zhu Chen
Liming Chen
Ralf Smeets
Thomas Beikler
Jan Strenge
Zhe Yang
Reinhard E. Friedrich
Publication date
01-12-2023
Publisher
BioMed Central
Keywords
Obesity
Obesity
Published in
BMC Oral Health / Issue 1/2023
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-023-03189-3

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