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Critical Care
Published in: Critical Care 1/2019

Open Access 01-12-2019 | Obesity | Review

ARDS in Obese Patients: Specificities and Management

Authors: Audrey De Jong, Daniel Verzilli, Samir Jaber

Published in: Critical Care | Issue 1/2019

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Abstract

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2019. Other selected articles can be found online at https://​www.​biomedcentral.​com/​collections/​annualupdate2019​. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://​www.​springer.​com/​series/​8901.
Literature
1.
Afshin A, Forouzanfar MH, Reitsma MB, et al. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med. 2017;377:13–27.CrossRef
2.
Hales CM, Fryar CD, Carroll MD, et al. Differences in obesity prevalence by demographic characteristics and urbanization level among adults in the United States, 2013–2016. JAMA. 2018;319:2419–29.CrossRef
3.
Pepin JL, Timsit JF, Tamisier R, et al. Prevention and care of respiratory failure in obese patients. Lancet Respir Med. 2016;4:407–18.CrossRef
4.
Ball L, Serpa Neto A, Pelosi P. Obesity and survival in critically ill patients with acute respiratory distress syndrome: a paradox within the paradox. Crit Care. 2017;21:114.CrossRef
5.
De Jong A, Molinari N, Pouzeratte Y, et al. Difficult intubation in obese patients: incidence, risk factors, and complications in the operating theatre and in intensive care units. Br J Anaesth. 2015;114:297–306.CrossRef
6.
Gong MN, Bajwa EK, Thompson BT, Christiani DC. Body mass index is associated with the development of acute respiratory distress syndrome. Thorax. 2010;65:44–50.CrossRef
7.
Anzueto A, Frutos-Vivar F, Esteban A, et al. Influence of body mass index on outcome of the mechanically ventilated patients. Thorax. 2011;66:66–73.CrossRef
8.
De Jong A, Molinari N, Sebbane M, et al. Feasibility and effectiveness of prone position in morbidly obese patients with ARDS: a case-control clinical study. Chest. 2013;143:1554–61.CrossRef
9.
O’Brien JM Jr, Phillips GS, Ali NA, et al. Body mass index is independently associated with hospital mortality in mechanically ventilated adults with acute lung injury. Crit Care Med. 2006;34:738–44.CrossRef
10.
Zhi G, Xin W, Ying W, et al. “Obesity paradox” in acute respiratory distress syndrome: asystematic review and meta-analysis. PLoS One. 2016;11:e0163677.CrossRef
11.
Shashaty MG, Stapleton RD. Physiological and management implications of obesity in critical illness. Ann Am Thorac Soc. 2014;11:1286–97.CrossRef
12.
De Jong A, Chanques G, Jaber S. Mechanical ventilation in obese ICU patients: from intubation to extubation. Crit Care. 2017;21:63.CrossRef
13.
14.
Gajic O, Dabbagh O, Park PK, et al. Early identification of patients at risk of acute lung injury: evaluation of lung injury prediction score in a multicenter cohort study. Am J Respir Crit Care Med. 2011;183:462–70.CrossRef
15.
Elie-Turenne MC, Hou PC, Mitani A, et al. Lung injury prediction score for the emergency department: first step towards prevention in patients at risk. Int J Emerg Med. 2012;5:33.CrossRef
16.
Kor DJ, Lingineni RK, Gajic O, et al. Predicting risk of postoperative lung injury in high-risk surgical patients: a multicenter cohort study. Anesthesiology. 2014;120(5):1168–81.CrossRef
17.
Levitt JE, Calfee CS, Goldstein BA, et al. Early acute lung injury: criteria for identifying lung injury prior to the need for positive pressure ventilation. Crit Care Med. 2013;41:1929–37.CrossRef
18.
O’Brien JM Jr, Welsh CH, Fish RH, et al. Excess body weight is not independently associated with outcome in mechanically ventilated patients with acute lung injury. Ann Intern Med. 2004;140:338–45.CrossRef
19.
Morris AE, Stapleton RD, Rubenfeld GD, et al. The association between body mass index and clinical outcomes in acute lung injury. Chest. 2007;131:342–8.CrossRef
20.
Stapleton RD, Dixon AE, Parsons PE, et al. The association between BMI and plasma cytokine levels in patients with acute lung injury. Chest. 2010;138:568–77.CrossRef
21.
Soto GJ, Frank AJ, Christiani DC, Gong MN. Body mass index and acute kidney injury in the acute respiratory distress syndrome. Crit Care Med. 2012;40:2601–8.CrossRef
22.
De Jong A, Cossic J, Verzilli D, et al. Impact of the driving pressure on mortality in obese and non-obese ARDS patients: a retrospective study of 362 cases. Intensive Care Med. 2018;44:1106–14.CrossRef
23.
Ni YN, Luo J, Yu H, et al. Can body mass index predict clinical outcomes for patients with acute lung injury/acute respiratory distress syndrome? A meta-analysis. Crit Care. 2017;21:36.CrossRef
24.
Brown SM, Wilson E, Presson AP, et al. Predictors of 6-month health utility outcomes in survivors of acute respiratory distress syndrome. Thorax. 2017;72:311–7.CrossRef
25.
Pelosi P, Croci M, Ravagnan I, et al. The effects of body mass on lung volumes, respiratory mechanics, and gas exchange during general anesthesia. Anesth Analg. 1998;87:654–60.PubMed
26.
De Jong A, Carreira S, Na N, et al. Diaphragmatic function is enhanced in fatty and diabetic fatty rats. PLoS One. 2017;12:e0174043.CrossRef
27.
De Jong A, Verzilli D, Sebbane M, et al. Medical versus surgical ICU obese patient outcome: a propensity-matched analysis to resolve clinical trial controversies. Crit Care Med. 2018;46:e294–301.CrossRef
28.
Burns SM, Egloff MB, Ryan B, et al. Effect of body position on spontaneous respiratory rate and tidal volume in patients with obesity, abdominal distension and ascites. Am J Crit Care. 1994;3:102–6.PubMed
29.
Jaber S, Bellani G, Blanch L, et al. The intensive care medicine research agenda for airways, invasive and noninvasive mechanical ventilation. Intensive Care Med. 2017;43:1352–65.CrossRef
30.
O’Brien JM Jr, Philips GS, Ali NA, et al. The association between body mass index, processes of care, and outcomes from mechanical ventilation: a prospective cohort study. Crit Care Med. 2012;40:1456–63.CrossRef
31.
Bime C, Fiero M, Lu Z, et al. High positive end-expiratory pressure is associated with improved survival in obese patients with acute respiratory distress syndrome. Am J Med. 2017;130:207–13.CrossRef
32.
Pirrone M, Fisher D, Chipman D, et al. Recruitment maneuvers and positive end-expiratory pressure titration in morbidly obese ICU patients. Crit Care Med. 2016;44:300–7.CrossRef
33.
Nestler C, Simon P, Petroff D, et al. Individualized positive end-expiratory pressure in obese patients during general anaesthesia: a randomized controlled clinical trial using electrical impedance tomography. Br J Anaesth. 2017;119:1194–205.CrossRef
34.
Amato MB, Meade MO, Slutsky AS, et al. Driving pressure and survival in the acute respiratory distress syndrome. N Engl J Med. 2015;372:747–55.CrossRef
35.
Guerin C, Papazian L, Reignier J, et al. Effect of driving pressure on mortality in ARDS patients during lung protective mechanical ventilation in two randomized controlled trials. Crit Care. 2016;20:384.CrossRef
36.
Behazin N, Jones SB, Cohen RI, Loring SH. Respiratory restriction and elevated pleural and esophageal pressures in morbid obesity. J Appl Physiol (1985). 2010;108:212–8.CrossRef
37.
Baedorf Kassis E, Loring SH, Talmor D. Mortality and pulmonary mechanics in relation to respiratory system and transpulmonary driving pressures in ARDS. Intensive Care Med. 2016;42:1206–13.CrossRef
38.
Eichler L, Truskowska K, Dupree A, Busch P, Goetz AE, Zöllner C. Intraoperative ventilation of morbidly obese patients guided by transpulmonary pressure. Obes Surg. 2018;28:122–9.CrossRef
39.
Fumagalli J, Berra L, Zhang C, et al. Transpulmonary pressure describes lung morphology during decremental positive end-expiratory pressure trials in obesity. Crit Care Med. 2017;45:1374–81.CrossRef
40.
Pandit JJ, Andrade J, Bogod DG, et al. 5th National Audit Project (NAP5) on accidental awareness during general anaesthesia: summary of main findings and risk factors. Br J Anaesth. 2014;113:549–59.CrossRef
41.
Guérin C, Reignier J, Richard JC, et al. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med. 2013;368:2159–68.CrossRef
42.
Weig T, Janitza S, Zoller M, et al. Influence of abdominal obesity on multiorgan dysfunction and mortality in acute respiratory distress syndrome patients treated with prone positioning. J Crit Care. 2014;29:557–61.CrossRef
43.
Combes A, Brodie D, Chen YS, et al. The ICM research agenda on extracorporeal life support. Intensive Care Med. 2017;43:1306–18.CrossRef
44.
Schmid C, Philipp A, Hilker M, et al. Venovenous extracorporeal membrane oxygenation for acute lung failure in adults. J Heart Lung Transplant. 2012;31:9–15.CrossRef
45.
Kon ZN, Dahi S, Evans CF, et al. Class III obesity is not a contraindication to venovenous extracorporeal membrane oxygenation support. Ann Thorac Surg. 2015;100:1855–60.CrossRef
46.
Salna M, Chicotka S, Biscotti M 3rd, et al. Morbid obesity is not a contraindication to transport on extracorporeal support. Eur J Cardiothorac Surg. 2018;53:793–8.CrossRef
47.
Combes A, Hajage D, Capellier G, et al. Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome. N Engl J Med. 2018;378:1965–75.CrossRef
48.
Swol J, Buchwald D, Dudda M, et al. Veno-venous extracorporeal membrane oxygenation in obese surgical patients with hypercapnic lung failure. Acta Anaesthesiol Scand. 2014;58:534–8.CrossRef
49.
Morelli A, Del Sorbo L, Pesenti A, et al. Extracorporeal carbon dioxide removal (ECCO2R) in patients with acute respiratory failure. Intensive Care Med. 2017;43:519–30.CrossRef
50.
Schmidt M, Jaber S, Zogheib E, et al. Feasibility and safety of low-flow extracorporeal CO2 removal managed with a renal replacement platform to enhance lung-protective ventilation of patients with mild-to-moderate ARDS. Crit Care. 2018;22:122.CrossRef
Metadata
Title
ARDS in Obese Patients: Specificities and Management
Authors
Audrey De Jong
Daniel Verzilli
Samir Jaber
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2019
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-019-2374-0

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