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BMC Complementary Medicine and Therapies

Anti-obesity effect of Neoagaro-oligosaccharides with overweight and obese subjects: a 16-week, randomized, double-blind, placebo-controlled clinical trial

  • Open Access
  • 01-12-2023
  • Obesity
  • Research
Published in:
Authors
Hyang-Im Baek
Ki-Chan Ha
Yu Kyung Park
Je Hyeon Lee
Eun Joo Kim
Hye-Jeong Ko
Jong Cheon Joo
Published in
BMC Complementary Medicine and Therapies | Issue 1/2023

Abstract

Background

This trial aimed to evaluate the anti-obesity effects and safety of Neoagaro-oligosaccharides (NAOs) in humans in a 16 week, randomized, double-blind, placebo-controlled clinical trial.

Methods

One hundred overweight or obese subjects with a body mass index of 23 to 34.9 kg/m2 and a percent body fat of > 25% for males or > 30% for females were enrolled. NAOs or placebo products were administered at 3 g (twice a day, four capsules once) each for 16 weeks. Efficacy and safety biomarkers were measured before and after intervention.

Results

After 16 weeks of intervention, the group administered with NAOs had statistically significant decreases in visceral fat area and visceral-subcutaneous fat area ratio compared to the placebo group. The NAOs group suppressed the increase in weight and BMI compared to the placebo group, which was significant between groups. High-density lipoprotein- cholesterol was increased in the group administered with NAOs, which showed a significant trend compared to the placebo group. Clinical changes were not observed for any safety biomarkers.

Conclusions

These results suggest that NAOs have a beneficial effect on obesity. Thus, NAOs could be used as an anti-obesity supplement without side effects.

Trial registration

cris.nih.go.kr: (KCT0006640, 07/10/2021).
Title
Anti-obesity effect of Neoagaro-oligosaccharides with overweight and obese subjects: a 16-week, randomized, double-blind, placebo-controlled clinical trial
Authors
Hyang-Im Baek
Ki-Chan Ha
Yu Kyung Park
Je Hyeon Lee
Eun Joo Kim
Hye-Jeong Ko
Jong Cheon Joo
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2023
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-023-04206-2
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