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CardioVascular and Interventional Radiology

23-04-2024 | Obesity | Clinical Investigation

Adding Short to Left Gastric Artery Embolization for the Treatment of Obesity: Safety and Effectiveness

Authors: Raphaël di Giuseppe, Boris Hansel, Jeremy Puyraimond Zemmour, Valérie Vilgrain, Maxime Ronot, Lorenzo Garzelli

Published in: CardioVascular and Interventional Radiology

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Abstract

Purpose

This study assessed the safety and effectiveness of a technical modification that involves adding short gastric artery (SGA) embolization to left gastric artery (LGA) embolization.

Material and Methods

This retrospective single-center study analyzed twenty obese patients (median age of 53.5 (30–73)) who were not eligible for bariatric surgery and underwent bariatric embolization with 300–500-µm microspheres in addition to a lifestyle counseling program between March 2021 and July 2022. Eight patients had LGA + SGA embolization, and twelve had LGA embolization alone. The primary outcome measure was total body weight loss (TBWL) at 6 months in the SGA + LGA and the LGA-only cohorts. Safety was assessed, defined as the 30-day adverse events rate according to the SIR classification.

Results

The mean 6-month post-embolization TBWL in the SGA + LGA cohort was 7.3 kg (95%CI 2.1–12.4; p = .01) and 4.1 kg (95%CI 0.4–8.6; p = 0.034) in the LGA-only cohort (mean difference − 3.1 kg ± 2.8; 95%CI (− 9.1–2.8); p = .28). The mean 6-month post-embolization TBWL in the entire cohort was 5.3 kg (p < .01). The rate of complications was similar between the two groups.

Conclusion

Combined SGA and LGA embolization is safe and effective to treat obesity. Larger studies are needed to determine whether SGA + LGA embolization results in more significant weight loss than LGA embolization alone.

Graphical Abstract

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Metadata
Title
Adding Short to Left Gastric Artery Embolization for the Treatment of Obesity: Safety and Effectiveness
Authors
Raphaël di Giuseppe
Boris Hansel
Jeremy Puyraimond Zemmour
Valérie Vilgrain
Maxime Ronot
Lorenzo Garzelli
Publication date
23-04-2024
Publisher
Springer US
Keywords
Obesity
Obesity
Published in
CardioVascular and Interventional Radiology
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-024-03702-3