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BMC Sports Science, Medicine and Rehabilitation
Published in: BMC Sports Science, Medicine and Rehabilitation 1/2013

Open Access 01-12-2013 | Review

Obesity, knee osteoarthritis and knee arthroplasty: a review

Authors: Saif Salih, Paul Sutton

Published in: BMC Sports Science, Medicine and Rehabilitation | Issue 1/2013

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Abstract

The incidence of obesity is rising worldwide. Obesity is a risk factor for developing osteoarthritis in the knee. Obesity and knee osteoarthritis are independently disabling conditions and in combination pose difficult therapeutic challenges. This review will discuss obesity, osteoarthritis, and the problems associated with knee osteoarthritis in an obese population. Treatment options including surgery and its success will be discussed.
Literature
1.
2.
3.
Taubes G: The science of obesity: what do we really know about what makes us fat? An essay by Gary Taubes. BMJ. 2013, 346: f1050-10.1136/bmj.f1050.CrossRefPubMed
4.
5.
Te Morenga L, Mallard S, Mann J: Dietary sugars and body weight: systematic review and meta-analyses of randomised controlled trials and cohort studies. BMJ. 2013, 346: e7492.CrossRef
6.
Cottrell RC, Wittekind A: Conclusions of review of dietary sugars and body weight are unwarranted. BMJ. 2013, 346: f1238-f1238. 10.1136/bmj.f1238.CrossRefPubMed
7.
8.
Buckwaler JA, Mankin HJ: Instructional course lectures, the American academy of orthopaedic surgeons - articular cartilage. Part II: degeneration and osteoarthrosis, repair, regeneration, and transplantation*†. J Bone Jt Surg. 1997, 79: 612-632.
9.
Sokolove J, Lepus CM: Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations. Ther Adv Musculoskelet Dis. 2013, 5: 77-94. 10.1177/1759720X12467868.CrossRefPubMedPubMedCentral
10.
Solomon L, Warwick D, Nayagam S, Apley AG: Apley’s system of orthopaedics and fractures. 2010, London: Hodder ArnoldCrossRef
11.
12.
Valdes AM, McWilliams D, Arden NK, Doherty SA, Wheeler M, Muir KR, Zhang W, Cooper C, Maciewicz RA, Doherty M: Involvement of different risk factors in clinically severe large joint osteoarthritis according to the presence of hand interphalangeal nodes. Arthritis Rheum. 2010, 62: 2688-2695. 10.1002/art.27574.CrossRefPubMed
13.
Ramachandran M: Stanmore Basic Orthopaedic Sciences: The Stanmore Guide. 2006, New York, USA: Hodder Arnold, 1
14.
Berenbaum F, Eymard F, Houard X: Osteoarthritis, inflammation and obesity. Curr Opin Rheumatol. 2013, 25: 114-118. 10.1097/BOR.0b013e32835a9414.CrossRefPubMed
15.
NICE: NICE Clinical Guideline 59 - Osteoarthritis. 2008, Manchester, UK: NICE
16.
Arden N, Nevitt MC: Osteoarthritis: epidemiology. Best Pract Res Clin Rheumatol. 2006, 20: 3-25. 10.1016/j.berh.2005.09.007.CrossRefPubMed
17.
Cicuttini FM, Baker J, Hart DJ, Spector TD: Association of pain with radiological changes in different compartments and views of the knee joint. Osteoarthr Cartil OARS Osteoarthr Res Soc. 1996, 4: 143-147. 10.1016/S1063-4584(05)80323-1.CrossRef
18.
Nguyen U-SDT, Zhang Y, Zhu Y, Niu J, Zhang B, Felson DT: Increasing prevalence of knee pain and symptomatic knee osteoarthritis: survey and cohort data. Ann Intern Med. 2011, 155: 725-732. 10.7326/0003-4819-155-11-201112060-00004.CrossRefPubMedPubMedCentral
19.
Van Saase JL, van Romunde LK, Cats A, Vandenbroucke JP, Valkenburg HA: Epidemiology of osteoarthritis: Zoetermeer survey. Comparison of radiological osteoarthritis in a Dutch population with that in 10 other populations. Ann Rheum Dis. 1989, 48: 271-280. 10.1136/ard.48.4.271.CrossRefPubMedPubMedCentral
20.
Farooqi A, Gibson T: Prevalence of the major rheumatic disorders in the adult population of north Pakistan. Br J Rheumatol. 1998, 37: 491-495. 10.1093/rheumatology/37.5.491.CrossRefPubMed
21.
Allison TR, Symmons DPM, Brammah T, Haynes P, Rogers A, Roxby M, Urwin M: Musculoskeletal pain is more generalised among people from ethnic minorities than among white people in Greater Manchester. Ann Rheum Dis. 2002, 61: 151-156. 10.1136/ard.61.2.151.CrossRefPubMedPubMedCentral
22.
Felson DT, Anderson JJ, Naimark A, Walker AM, Meenan RF: Obesity and knee osteoarthritis. The Framingham study. Ann Intern Med. 1988, 109: 18-24. 10.7326/0003-4819-109-1-18.CrossRefPubMed
23.
Cicuttini F, Baker J, Spector TD: The association of obesity with osteoarthritis of the hand and knee in women: a twin study. J Rheumatol. 1996, 23: 1221-1226.PubMed
24.
Jinks C, Jordan K, Croft P: Disabling knee pain–another consequence of obesity: results from a prospective cohort study. BMC Public Health. 2006, 6: 258-10.1186/1471-2458-6-258.CrossRefPubMedPubMedCentral
25.
Blagojevic M, Jinks C, Jeffery A, Jordan KP: Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis. Osteoarthr Cartil OARS Osteoarthr Res Soc. 2010, 18: 24-33. 10.1016/j.joca.2009.08.010.CrossRef
26.
Gunardi AJ, Brennan SL, Wang Y, Cicuttini FM, Pasco JA, Kotowicz MA, Nicholson GC, Wluka AE: Associations between measures of adiposity over 10 years and patella cartilage in population-based asymptomatic women. Int J Obes 2005. 2013, doi: 10.1038/ijo.2013.42
27.
28.
Osborn O, Olefsky JM: The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med. 2012, 18: 363-374. 10.1038/nm.2627.CrossRefPubMed
29.
De Boer TN, van Spil WE, Huisman AM, Polak AA, Bijlsma JWJ, Lafeber FPJG, Mastbergen SC: Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage. Osteoarthr Cartil OARS Osteoarthr Res Soc. 2012, 20: 846-853. 10.1016/j.joca.2012.05.002.CrossRef
30.
Berry PA, Jones SW, Cicuttini FM, Wluka AE, Maciewicz RA: Temporal relationship between serum adipokines, biomarkers of bone and cartilage turnover, and cartilage volume loss in a population with clinical knee osteoarthritis. Arthritis Rheum. 2011, 63: 700-707. 10.1002/art.30182.CrossRefPubMed
31.
Van Spil WE, Welsing PMJ, Kloppenburg M, Bierma-Zeinstra SM, Bijlsma JWJ, Mastbergen SC, Lafeber FPJG: Cross-sectional and predictive associations between plasma adipokines and radiographic signs of early-stage knee osteoarthritis: data from CHECK. Osteoarthr Cartil OARS Osteoarthr Res Soc. 2012, 20: 1278-1285. 10.1016/j.joca.2012.08.001.CrossRef
32.
Berry PA, Wluka AE, Davies-Tuck ML, Wang Y, Strauss BJ, Dixon JB, Proietto J, Jones G, Cicuttini FM: The relationship between body composition and structural changes at the knee. Rheumatol Oxf Engl. 2010, 49: 2362-2369. 10.1093/rheumatology/keq255.CrossRef
33.
Gudbergsen H, Boesen M, Lohmander LS, Christensen R, Henriksen M, Bartels EM, Christensen P, Rindel L, Aaboe J, Danneskiold-Samsøe B, Riecke BF, Bliddal H: Weight loss is effective for symptomatic relief in obese subjects with knee osteoarthritis independently of joint damage severity assessed by high-field MRI and radiography. Osteoarthr Cartil OARS Osteoarthr Res Soc. 2012, 20: 495-502. 10.1016/j.joca.2012.02.639.CrossRef
34.
Gudbergsen H, Boesen M, Christensen R, Astrup A, Bliddal H: Radiographs and low field MRI (0.2T) as predictors of efficacy in a weight loss trial in obese women with knee osteoarthritis. BMC Musculoskelet Disord. 2011, 12: 56-10.1186/1471-2474-12-56.CrossRefPubMedPubMedCentral
35.
Karvonen-Gutierrez CA, Sowers MR, Heeringa SG: Sex dimorphism in the association of cardiometabolic characteristics and osteophytes-defined radiographic knee osteoarthritis among obese and non-obese adults: NHANES III. Osteoarthr Cartil OARS Osteoarthr Res Soc. 2012, 20: 614-621. 10.1016/j.joca.2012.02.644.CrossRef
36.
Goulston LM, Kiran A, Javaid MK, Soni A, White KM, Hart DJ, Spector TD, Arden NK: Does obesity predict knee pain over fourteen years in women, independently of radiographic changes?. Arthritis Care Res. 2011, 63: 1398-1406. 10.1002/acr.20546.CrossRef
37.
Dowsey MM, Liew D, Stoney JD, Choong PF: The impact of pre-operative obesity on weight change and outcome in total knee replacement: a prospective study of 529 consecutive patients. J Bone Joint Surg Br. 2010, 92: 513-520.CrossRefPubMed
38.
Changulani M, Kalairajah Y, Peel T, Field RE: The relationship between obesity and the age at which hip and knee replacement is undertaken. J Bone Joint Surg Br. 2008, 90: 360-363.CrossRefPubMed
39.
NJR: 9th Annual Report; National Joint Registry. 2012, Hemel Hempsted UK: NJR Centre
40.
Vasarhelyi EM, MacDonald SJ: The influence of obesity on total joint arthroplasty. J Bone Joint Surg Br. 2012, 94: 100-102.CrossRefPubMed
41.
Kerkhoffs GMMJ, Servien E, Dunn W, Dahm D, Bramer JAM, Haverkamp D: The influence of obesity on the complication rate and outcome of total knee arthroplasty: a meta-analysis and systematic literature review. J Bone Joint Surg Am. 2012, 94: 1839-1844. 10.2106/JBJS.K.00820.CrossRefPubMedPubMedCentral
42.
Järvenpää J, Kettunen J, Soininvaara T, Miettinen H, Kröger H: Obesity has a negative impact on clinical outcome after total knee arthroplasty. Scand J Surg SJS Off Organ Finn Surg Soc Scand Surg Soc. 2012, 101: 198-203.
43.
Amin AK, Patton JT, Cook RE, Brenkel IJ: Does obesity influence the clinical outcome at five years following total knee replacement for osteoarthritis?. J Bone Joint Surg Br. 2006, 88: 335-340.CrossRefPubMed
44.
Pritchett JW, Bortel DT: Knee replacement in morbidly obese women. Surg Gynecol Obstet. 1991, 173: 119-122.PubMed
45.
Winiarsky R, Barth P, Lotke P: Total knee arthroplasty in morbidly obese patients. J Bone Joint Surg Am. 1998, 80: 1770-1774.PubMed
46.
Krushell RJ, Fingeroth RJ: Primary total knee arthroplasty in morbidly obese patients: a 5- to 14-year follow-up study. J Arthroplasty. 2007, 22: 77-80. 10.1016/j.arth.2007.03.024.CrossRefPubMed
47.
Sridhar MS, Jarrett CD, Xerogeanes JW, Labib SA: Obesity and symptomatic osteoarthritis of the knee. J Bone Joint Surg Br. 2012, 94: 433-440.CrossRefPubMed
48.
Amin AK, Clayton RAE, Patton JT, Gaston M, Cook RE, Brenkel IJ: Total knee replacement in morbidly obese patients: results of a prospective, matched study. J Bone Joint Surg Br. 2006, 88: 1321-1326.CrossRefPubMed
49.
Mantilla CB, Horlocker TT, Schroeder DR, Berry DJ, Brown DL: Risk factors for clinically relevant pulmonary embolism and deep venous thrombosis in patients undergoing primary hip or knee arthroplasty. Anesthesiology. 2003, 99: 552-560. 10.1097/00000542-200309000-00009. discussion 5ACrossRefPubMed
50.
Bordini B, Stea S, Cremonini S, Viceconti M, De Palma R, Toni A: Relationship between obesity and early failure of total knee prostheses. BMC Musculoskelet Disord. 2009, 10: 29-10.1186/1471-2474-10-29.CrossRefPubMedPubMedCentral
51.
McKellop HA, Campbell P, Park SH, Schmalzried TP, Grigoris P, Amstutz HC, Sarmiento A: The origin of submicron polyethylene wear debris in total hip arthroplasty. Clin Orthop. 1995, 311: 3-20.PubMed
52.
Foran JRH, Mont MA, Etienne G, Jones LC, Hungerford DS: The outcome of total knee arthroplasty in obese patients. J Bone Joint Surg Am. 2004, 86-A: 1609-1615.PubMed
53.
Vazquez-Vela Johnson G, Worland RL, Keenan J, Norambuena N: Patient demographics as a predictor of the ten-year survival rate in primary total knee replacement. J. Bone Joint Surg. Br. 2003, 85: 52-56. 10.1302/0301-620X.85B1.12992.CrossRefPubMed
54.
Jones CA, Cox V, Jhangri GS, Suarez-Almazor ME: Delineating the impact of obesity and its relationship on recovery after total joint arthroplasties. Osteoarthr Cartil OARS Osteoarthr Res Soc. 2012, 20: 511-518. 10.1016/j.joca.2012.02.637.CrossRef
55.
Collins RA, Walmsley PJ, Amin AK, Brenkel IJ, Clayton RAE: Does obesity influence clinical outcome at nine years following total knee replacement?. J Bone Joint Surg Br. 2012, 94: 1351-1355.CrossRefPubMed
56.
Samson AJ, Mercer GE, Campbell DG: Total knee replacement in the morbidly obese: a literature review. ANZ J Surg. 2010, 80: 595-599. 10.1111/j.1445-2197.2010.05396.x.CrossRefPubMed
57.
Rajgopal V, Bourne RB, Chesworth BM, MacDonald SJ, McCalden RW, Rorabeck CH: The impact of morbid obesity on patient outcomes after total knee arthroplasty. J Arthroplasty. 2008, 23: 795-800. 10.1016/j.arth.2007.08.005.CrossRefPubMed
58.
Abu-Abeid S, Wishnitzer N, Szold A, Liebergall M, Manor O: The influence of surgically-induced weight loss on the knee joint. Obes Surg. 2005, 15: 1437-1442. 10.1381/096089205774859281.CrossRefPubMed
59.
Parvizi J, Trousdale RT, Sarr MG: Total joint arthroplasty in patients surgically treated for morbid obesity. J Arthroplasty. 2000, 15: 1003-1008. 10.1054/arth.2000.9054.CrossRefPubMed
Metadata
Title
Obesity, knee osteoarthritis and knee arthroplasty: a review
Authors
Saif Salih
Paul Sutton
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Sports Science, Medicine and Rehabilitation / Issue 1/2013
Electronic ISSN: 2052-1847
DOI
https://doi.org/10.1186/2052-1847-5-25

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