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17-01-2024 | Nutrition | Original Article

Clearance and nutrition in neonatal continuous kidney replacement therapy using the Carpediem™ system

Authors: Kim T. Vuong, Molly R. Vega, Lauren Casey, Sarah J. Swartz, Poyyapakkam Srivaths, Scott W. Osborne, Christopher J. Rhee, Ayse Akcan Arikan, Catherine Joseph

Published in: Pediatric Nephrology | Issue 6/2024

Abstract

Background

Infants with kidney failure (KF) demonstrate poor growth partly due to obligate fluid and protein restrictions. Delivery of liberalized nutrition on continuous kidney replacement therapy (CKRT) is impacted by clinical instability, technical dialysis challenges, solute clearance, and nitrogen balance. We analyzed delivered nutrition and growth in infants receiving CKRT with the Cardio-Renal, Pediatric Dialysis Emergency Machine (Carpediem™).

Methods

Single-center observational study of infants receiving CKRT with the Carpediem™ between June 1 and December 31, 2021. We collected prospective circuit characteristics, delivered nutrition, anthropometric measurements, and illness severity Score for Neonatal Acute Physiology-II. As a surrogate to normalized protein catabolic rate in maintenance hemodialysis, we calculated normalized protein nitrogen appearance (nPNA) using the Randerson II continuous dialysis model. Descriptive statistics, Spearman correlation coefficient, Mann Whitney, Wilcoxon signed rank, receiver operating characteristic curves, and Kruskal–Wallis analysis were performed using SAS version 9.4.

Results

Eight infants received 31.9 (22.0, 49.7) days of CKRT using mostly (90%) regional citrate anticoagulation. Delivered nutritional volume, protein, total calories, enteral calories, nPNA, and nitrogen balance increased on CKRT. Using parenteral nutrition, 90 ml/kg/day should meet caloric and protein needs. Following initial weight loss of likely fluid overload, exploratory sensitivity analysis suggests weight gain occurred after 14 days of CKRT. Despite adequate nutritional delivery, goal weight (z-score = 0) and growth velocity were not achieved until 6 months after CKRT start. Most (5 infants, 62.5%) survived and transitioned to peritoneal dialysis (PD).

Conclusions

Carpediem™ is a safe and efficacious bridge to PD in neonatal KF. Growth velocity of infants on CKRT appears delayed despite delivery of adequate calories and protein.

Graphical abstract

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Title: Clearance and nutrition in neonatal continuous kidney replacement therapy using the Carpediem™ system
Authors: Kim T. Vuong
Molly R. Vega
Lauren Casey
Sarah J. Swartz
Poyyapakkam Srivaths
Scott W. Osborne
Christopher J. Rhee
Ayse Akcan Arikan
Catherine Joseph
Publication date: 17-01-2024
Publisher: Springer Berlin Heidelberg
Keywords: Nutrition
Peritoneal Dialysis
Published in: Pediatric Nephrology / Issue 6/2024
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-023-06237-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Clearance and nutrition in neonatal continuous kidney replacement therapy using the Carpediem™ system

Abstract

Background

Methods

Results

Conclusions

Graphical abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Graphical abstract

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