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Inflammopharmacology
Published in: Inflammopharmacology 5/2020

01-10-2020 | Nutrition | COMMENTARY

Conditional nutrition (I): concerning zinc as a beneficial but variable regulator of inflammation and experimental arthritis

Author: Michael W. Whitehouse

Published in: Inflammopharmacology | Issue 5/2020

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Abstract

This article extends the concept of conditional pharmacology (Whitehouse and Vernon-Roberts 1991; Whitehouse 1995) that considers how both internal factors/disease and external/environmental factors may alter the availability or efficacy of exogenous drugs. The same and other conditioning factors may also affect the utility and value of many nutriceuticals that may be clearly beneficial in the context of inflammation but sometimes showing quite variable pharmaco-activity. This is illustrated by considering some factors affecting the bioavailability and pharmaco-efficacy of dietary ionic zinc, Zn (II) an essential trace metal and a critical regulator of inflammation and tissue repair. With chronic zinc deficiency (zincopenia) due to diet, drugs and/or disease, we can usually survive—but may not necessarily thrive. Some strategies to minimise zincopenia are considered, based upon finding efficient means for (1) preventing its cause and/or (2) using parenteral delivery of zinc supplements to circumvent dietary and enteric impediments to zinc bio-availability.
Footnotes
1
Forming aurocyanide or some other active metabolites (Graham et al 2008)
 
Literature
Apisarlyakulm MA, Buddhasukh D, Apisariyakul S, Ternai B (1990) Zinc monoglycerolate is effective against oral herpetic sores. Med J Aust 152:164
Atkins RC (2002) Dr Atkins vita-nutrient solutions. Pocket Books (Simon & Schuster). London, pp 141–146
Baltaci AK, Mogulkoc R, Baltaci SB (2019) Review: the role of zinc in the endocrine systems. Pak J Pharm Sci 32:231–239
Bao B, Prasad AS, Beck FWJ et al (2010) Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent. Am J Clin Nutr 91:1634–2164PubMedPubMedCentral
Beck FW, Kaplan J, Fine N, Handschu W, Prasad AS (1997) Decreased expression of CD73 (ecto-5’-nucleotidase) in the CD8+ subset is associated with zinc deficiency in human patients. J Lab Clin Med 130:147–156PubMed
Berg J, Shi Y (1996) The galvanisation of biology: a growing appreciation of the role of zinc. Science 271:1081–1085PubMed
Braun L, Cohen M (2010) Zinc in herbs & natural supplements. An evidence-based guide, 3rd edn. Elsevier, Australia, pp 1037–1054
Brewer GJ, Prasad AS (eds) (1977) Zinc Metabolism: current aspects in health and disease. Alan R Liss Inc, New York
Bryce-Smith D, Hodgkingson L (1986) The zinc solution. Century Arrow, London, p 176
Coleman JE (1992) Zinc proteins: enzymes, storage proteins, transcription factors and replication proteins. Ann Rev Biochem 61:897–994PubMed
Connell P, Young VM, Toberek M et al (1997) Zinc attenuates TNF-mediated activation of transcription factors. (NFkappaB, AP-1) in endothelial cells. J Am Coll Nutr 16:411–417PubMed
Cooper KH (1996) Advanced nutritional therapies. Thos Nelson Inc, Nashville, pp 349–355
Cunnane SC, Huang YS, Horrobin DF, Davignon J (1981) Role of zinc in linoleic acid desaturation and prostaglandin synthesis. Prog Lipid Res 20:157–160PubMed
Cunningham-Rundles S (1996) Zinc modulation of immune function: specificity and mechanism of action. J Lab Clin Med 128:9–11PubMed
Davies S, Stewart A (1987) Nutritional medicine: the drug-free guide to better family health. Pan Books, London, pp 63–73 with 28 other pages noting zinc deficiencies
Fairlie DP, Whitehouse MW, Taylor TM (1992) Zinc monoglycerolate; a slow-release source of zinc and glycerol: solubilisation by bioconstituent ligands. Agents Actions 36:152–158PubMed
Frausto da Silva JJR, Williams RJP (2001) The biological chemistry of the elements, 2nd edn. Clarendon Press, Oxford, vol 11, pp 315–339
Frederickson CJ, Suk SW, Silva D, Frederickson CT, Thompson RV (1483S) Importance of zinc in the nervous system: the zinc-containing neuron. J Nutr 130(5 Suppl):1471S–1483SPubMed
Fujioka M, Kieberman I (1964) A Zn++ requirement for synthesis of DNA. J Biol Chem 239:1164–1167PubMed
Graham GG, Whitehouse MW, Bushell GR (2008) Aurocyanide, dicyano-aurate (I), a pharmacologically active metabolite of medicinal gold complexes. Inflammopharmacol 16:126–132
Haase H, Mocchegiani E, Rink L (2006) Correlation between zinc status and immune function in the elderly. Biogerentology 7:421–428
Hanssen M, Marsden J (1989) The new (E for) additive code breaker. Everything you should know about additives in your food. Melbourne, TC Lothian Pty Ltd, p 199
Higdon JV, Ho E (2005) The role of zinc as a metallotherapeutic agent. In: Gielen M, Tiekink ERT (eds) Metallotherapeutic drugs & metal-based diagnostic agents. John Wiley & Sons Ltd., Chichester (see chapter 13, pp 237–273)
Huang YS, Cunnane SC, Horrobin DF, Davignon J (1981) Most biological effects of zinc deficiency corrected by gamma-linolenic acid (18:3ω−6) but not by linoleic acid (18:2ω−6). Atherosclerosis 41:193–207
Hyman M (2006) Ultra-metabolism. Simon & Schuster, New York, p 327
Jones B, Dixon MW (1989) MacMillan dictionary of biography, 3rd edn. MacMillan Co Australia P/L., South Melbourne, p 405
Keen CL, Hurley LS (1977) Zinc absorption through skin: correction of zinc deficiency in the rat. Am J Clin Nutr 30:528–530PubMed
Kim J, Kim S, Jeon S et al (2015) Anti-inflammatory effects of zinc in PMA-treated human gingival fibroblast cells. Med Oral Patol Car Bucal 20(2):180–187
Klug A (1999) Zinc finger peptides for the regulation of gene expression. J Mol Biol 293:215–218PubMed
Lawrence F (2004) Not on the label. What really goes into the food on your plate? (see chapter 7 “The ready meal’). Penguin Books Ltd, London, p 272
Lipscomb WL, Strater N (1996) Recent advances in zinc enzymology. Chem Rev 96:2375–2433PubMed
Lundager MHE, Christensen HH, Gottlieb-Petersen C (1978) Stability constants of copper(II), zinc, manganese(II), calcium, and magnesium complexes of N-(phosphonomethyl)glycine (glyphosate). Acta Chem Scand A32:79–83
Nestle M (2013) Food politics. How the Food industry influences Nutrition and Health. University of California Press, Berkeley, p 534
Prasad AS, Bao B, Beck FW, Kucuk O, Sarkar FH (2004) Antioxidant effect of zinc in humans. Free Radic Biol Med 37:1182–1190PubMed
Prasad AA, Bao B, Beck FW, Sarkar FH (2011) Zinc-suppressed inflammatory cytokines by induction of A20-mediated inhibition of nuclear factor-kB. Nutrition 27:816–823PubMed
Rainsford KD, Whitehouse MW (1992) Anti-ulcer activity of a slow-release zinc complex, zinc monoglycerolate Glyzinc®. J Pharm Pharmacol 44:476–482PubMed
Salgueiro MJ, Boccio J (2002) Editorial. Zinc intake versus zinc absorption: a bioavailability factor. Nutrition 18:354PubMed
Salgueiro MJ, Zubilliago M, Lysiomeka A, Cremaschi G, Goldman CG, Caro R et al (2000) Zinc status and immune system relationship. Biol Trace Elem Res 76:193–205PubMed
Sanstead HH (1985) Zinc: essentiality for brain development and function. Nutr Rev 43:129–137
Sanstead HH (1991) Zinc deficiency: a public health problem. Am J Dis Child 145:839–859
Sargent S (1985) The foodmakers. [They] control what we eat Ringwood Vic. Penguin Books, Australia
Strand RD (2002) What your doctor doesn’t know about nutritional medicine may be killing you. Strand Publishing and USA Thos Nelson Inc, Sydney, pp 101–102
Vallee B, Falchuk K (1993) The biochemical basis of zinc physiology. Physiol Rev 73:79–118PubMed
Whitehouse MW (1992) Trace elements supplements for inflammatory disease in Eds Dixon JS, Furst DE. Second-line agents in the treatment of rheumatoid diseases. Marcel & Dekker Inc, New York, pp 549–578
Whitehouse MW (1995) Inflammation, stress and environmental factors as determinants of NSAID efficiency and toxicity. Inflammopharmacol 3:373–377
Whitehouse MW, Field L, Hanley WS (1977) A potential hazard, the toxicity of zinc with d-penicillamine (letter). Arthritis Rheum 20:1035PubMed
Whitehouse MW, Hann C, Vernon-Roberts B (2020) Conditional nutrition II. Variable bioavailability of therapeutic fatty acids with inflammatory disease: efficacy of transdermal zinc salts of PUFA for treating rat polyarthritis. Inflammopharmacol (to be submitted)
Whitehouse MW, Rainsford KD, Taylor RM, Vernon-Roberts B (1990) Zinc monoglycerolate: a slow-release source of zinc with anti-arthritic activity in rats. Agents Actions 31:47–58PubMed
Whitehouse MW, Vernon-Roberts B (1991) Conditional pharmacology: expression of antiinflammatory activity may require pre-existent inflammatory mediators/hormones. Inflammopharmacol 1:61–68
Winson A (2013) The industrial diet: the degradation of food and the struggle for healthy eating. Univ of British Columbia Press (also published by Oxford University Press), Vancouver, p 352
Yagi T, Asakawa A, Ueda H, Ikeda S, Miyawaki S, Inui A (2013) The role of zinc in the treatment of taste disorders. Recent Pat Food Nutr Agric 5:44–51PubMed
Zhao T, Huang Q, Su Y, Sun W, Huang Q, Wen W (2019) Zinc and its regulators in the pancreas. Inflammopharmacol 27:453–464
Metadata
Title
Conditional nutrition (I): concerning zinc as a beneficial but variable regulator of inflammation and experimental arthritis
Author
Michael W. Whitehouse
Publication date
01-10-2020
Publisher
Springer International Publishing
Keyword
Nutrition
Published in
Inflammopharmacology / Issue 5/2020
Print ISSN: 0925-4692
Electronic ISSN: 1568-5608
DOI
https://doi.org/10.1007/s10787-019-00669-3

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