Nutrition | Nocturia is Associated with High Atherosclerotic Cardiovascular Disease Risk in Women: Results from the National Health and Nutrition Examination Survey | springermedicine.com

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Journal of Community Health

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01-08-2021 | Nutrition | Original Paper

Nocturia is Associated with High Atherosclerotic Cardiovascular Disease Risk in Women: Results from the National Health and Nutrition Examination Survey

Authors: Jason M. Lazar, Muchi Ditah Chobufo, Jeffrey P. Weiss, Karel Everaert, Tine De Backer, Alan J. Wein, F. Charles Brunicardi, Thomas F. Monaghan

Published in: Journal of Community Health | Issue 4/2021

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Abstract

Growing evidence has identified nocturia as a potential manifestation of several cardiovascular disease states. We aimed to determine whether a relationship exists between nocturia and global atherosclerotic cardiovascular disease (ASCVD) risk, defined by the American College of Cardiology/American Heart Association (ACC/AHA) ASCVD risk calculator, using a large nationally-representative study sample from the United States. We explored potential associations between nocturia and ASCVD risk in adults aged 40–79 years with no prior history of overt/known atherosclerotic disease from 7 consecutive cycles of the National Health and Nutrition Examination Survey. Subjects were classified by whether they met the ASCVD high-risk threshold following current ACC/AHA consensus guidelines (10-year major adverse cardiovascular event risk ≥ 20%). Logistic regression analyses were used to explore associations between nocturia (defined as ≥ 2 nocturnal voids) and ASCVD risk. The prevalence of nocturia and high ASCVD risk were 27.0% and 10.9%, respectively. Nocturia, older age, increased body mass index, and diuretic use were associated with high ASCVD risk on univariate logistic regression. After adjusting for age, body mass index, and diuretic use, nocturia remained associated with significantly greater odds of high ASCVD risk in females but not in males. Elicitation of nocturia on clinical history taking may serve to identify high cardiovascular risk in females. Future studies are needed to elucidate mechanisms underlying this association.

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Title: Nocturia is Associated with High Atherosclerotic Cardiovascular Disease Risk in Women: Results from the National Health and Nutrition Examination Survey
Authors: Jason M. Lazar
Muchi Ditah Chobufo
Jeffrey P. Weiss
Karel Everaert
Tine De Backer
Alan J. Wein
F. Charles Brunicardi
Thomas F. Monaghan
Publication date: 01-08-2021
Publisher: Springer US
Keywords: Nutrition
Arterial Occlusive Disease
Published in: Journal of Community Health / Issue 4/2021
Print ISSN: 0094-5145
Electronic ISSN: 1573-3610
DOI: https://doi.org/10.1007/s10900-021-00962-9

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