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Published in: Critical Care 1/2021

Open Access 01-12-2021 | Nutrition | Review

A guide to enteral nutrition in intensive care units: 10 expert tips for the daily practice

Authors: Jean-Charles Preiser, Yaseen M. Arabi, Mette M. Berger, Michael Casaer, Stephen McClave, Juan C. Montejo-González, Sandra Peake, Annika Reintam Blaser, Greet Van den Berghe, Arthur van Zanten, Jan Wernerman, Paul Wischmeyer

Published in: Critical Care | Issue 1/2021

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Abstract

The preferential use of the oral/enteral route in critically ill patients over gut rest is uniformly recommended and applied. This article provides practical guidance on enteral nutrition in compliance with recent American and European guidelines. Low-dose enteral nutrition can be safely started within 48 h after admission, even during treatment with small or moderate doses of vasopressor agents. A percutaneous access should be used when enteral nutrition is anticipated for ≥ 4 weeks. Energy delivery should not be calculated to match energy expenditure before day 4–7, and the use of energy-dense formulas can be restricted to cases of inability to tolerate full-volume isocaloric enteral nutrition or to patients who require fluid restriction. Low-dose protein (max 0.8 g/kg/day) can be provided during the early phase of critical illness, while a protein target of > 1.2 g/kg/day could be considered during the rehabilitation phase. The occurrence of refeeding syndrome should be assessed by daily measurement of plasma phosphate, and a phosphate drop of 30% should be managed by reduction of enteral feeding rate and high-dose thiamine. Vomiting and increased gastric residual volume may indicate gastric intolerance, while sudden abdominal pain, distension, gastrointestinal paralysis, or rising abdominal pressure may indicate lower gastrointestinal intolerance.
Literature
2.
go back to reference Barazzoni R, Bischoff SC, Breda J, Wickramasinghe K, Krznaric Z, Nitzan D, et al. ESPEN expert statements and practical guidance for nutritional management of individuals with SARS-CoV-2 infection. Clin Nutr. 2020;39:1631–8.PubMedPubMedCentral Barazzoni R, Bischoff SC, Breda J, Wickramasinghe K, Krznaric Z, Nitzan D, et al. ESPEN expert statements and practical guidance for nutritional management of individuals with SARS-CoV-2 infection. Clin Nutr. 2020;39:1631–8.PubMedPubMedCentral
3.
go back to reference Preiser J-C, van Zanten ARH, Berger MM, Biolo G, Casaer MP, Doig GS, et al. Metabolic and nutritional support of critically ill patients: consensus and controversies. Crit Care. 2015;19:35.PubMedPubMedCentral Preiser J-C, van Zanten ARH, Berger MM, Biolo G, Casaer MP, Doig GS, et al. Metabolic and nutritional support of critically ill patients: consensus and controversies. Crit Care. 2015;19:35.PubMedPubMedCentral
4.
go back to reference Wernerman J, Christopher KB, Annane D, Casaer MP, Coopersmith CM, Deane AM, et al. Metabolic support in the critically ill: a consensus of 19. Crit Care. 2019;23:1–10. Wernerman J, Christopher KB, Annane D, Casaer MP, Coopersmith CM, Deane AM, et al. Metabolic support in the critically ill: a consensus of 19. Crit Care. 2019;23:1–10.
5.
go back to reference Reintam Blaser A, Starkopf J, Alhazzani W, et al. Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines. Intensive Care Med. 2017;43:380–98.PubMedPubMedCentral Reintam Blaser A, Starkopf J, Alhazzani W, et al. Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines. Intensive Care Med. 2017;43:380–98.PubMedPubMedCentral
6.
go back to reference Taylor BE, McClave SA, Martindale RG, Warren MM, Johnson DR, Braunschweig C, et al. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (ASPEN). Crit Care Med. 2016;44:390–438.PubMed Taylor BE, McClave SA, Martindale RG, Warren MM, Johnson DR, Braunschweig C, et al. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (ASPEN). Crit Care Med. 2016;44:390–438.PubMed
7.
go back to reference Singer P, Reintam Blaser A, Berger MM, et al. ESPEN guideline on clinical nutrition in the intensive care unit. Clin Nutr. 2019;38:48–79.PubMed Singer P, Reintam Blaser A, Berger MM, et al. ESPEN guideline on clinical nutrition in the intensive care unit. Clin Nutr. 2019;38:48–79.PubMed
8.
go back to reference Preiser J-C, Ichai C, Orban J-C, Groeneveld ABJ. Metabolic response to the stress of critical illness. Br J Anaesth. 2014;2014:1–10. Preiser J-C, Ichai C, Orban J-C, Groeneveld ABJ. Metabolic response to the stress of critical illness. Br J Anaesth. 2014;2014:1–10.
9.
go back to reference McClave SA, Lowen CC, Rg M. The 2016 ESPEN Arvid Wretlind lecture: the gut in stress. Clin Nutr. 2018;37:19–36.PubMed McClave SA, Lowen CC, Rg M. The 2016 ESPEN Arvid Wretlind lecture: the gut in stress. Clin Nutr. 2018;37:19–36.PubMed
10.
go back to reference Buchman AL, Moukarzel AA, Bhuta S, Belle M, Ament ME, Eckhert CD, et al. Parenteral nutrition is associated with intestinal morphologic and functional changes in humans. JPEN J Parenter Enter Nutr. 1995;19:453–60. Buchman AL, Moukarzel AA, Bhuta S, Belle M, Ament ME, Eckhert CD, et al. Parenteral nutrition is associated with intestinal morphologic and functional changes in humans. JPEN J Parenter Enter Nutr. 1995;19:453–60.
11.
go back to reference Nguyen NQ, Besanko LK, Burgstad C, Bellon M, Holloway RH, Chapman M, et al. Delayed enteral feeding impairs intestinal carbohydrate absorption in critically ill patients. Crit Care Med. 2012;40:50–4.PubMed Nguyen NQ, Besanko LK, Burgstad C, Bellon M, Holloway RH, Chapman M, et al. Delayed enteral feeding impairs intestinal carbohydrate absorption in critically ill patients. Crit Care Med. 2012;40:50–4.PubMed
13.
go back to reference Tian F, Heighes PT, Allingstrup MJ, Doig GS. Early enteral nutrition provided within 24 hours of ICU admission: a meta-analysis of randomized controlled trials. Crit Care Med. 2018;2018:1049–56. Tian F, Heighes PT, Allingstrup MJ, Doig GS. Early enteral nutrition provided within 24 hours of ICU admission: a meta-analysis of randomized controlled trials. Crit Care Med. 2018;2018:1049–56.
14.
go back to reference Fuentes Padilla P, Martinez G, Vernooij RW, Urrutia G, Ifm R, Bonfill Cosp X. Early enteral nutrition (within 48 h) versus delayed enteral nutrition (after 48 h) with or without supplemental parenteral nutrition in critically ill adults. Cochrane Database Syst Rev. 2019;2019:10. Fuentes Padilla P, Martinez G, Vernooij RW, Urrutia G, Ifm R, Bonfill Cosp X. Early enteral nutrition (within 48 h) versus delayed enteral nutrition (after 48 h) with or without supplemental parenteral nutrition in critically ill adults. Cochrane Database Syst Rev. 2019;2019:10.
15.
go back to reference Berger MM, Reintam-Blaser A, Calder PC, Casaer M, Hiesmayr MJ, Mayer K, et al. Monitoring nutrition in the ICU. Clin Nutr. 2019;38:584–93.PubMed Berger MM, Reintam-Blaser A, Calder PC, Casaer M, Hiesmayr MJ, Mayer K, et al. Monitoring nutrition in the ICU. Clin Nutr. 2019;38:584–93.PubMed
16.
go back to reference Arabi YM, Sa M. Enteral nutrition should not be given to patients on vasopressor agents. Crit Care Med. 2020;48:119–21.PubMed Arabi YM, Sa M. Enteral nutrition should not be given to patients on vasopressor agents. Crit Care Med. 2020;48:119–21.PubMed
18.
go back to reference Berger MM, Berger-Gryllaki M, Wiesel PH, et al. Intestinal absorption in patients after cardiac surgery. Crit Care Med. 2000;28:2217–23.PubMed Berger MM, Berger-Gryllaki M, Wiesel PH, et al. Intestinal absorption in patients after cardiac surgery. Crit Care Med. 2000;28:2217–23.PubMed
19.
go back to reference Melis M, Fichera A, Mk F. Bowel necrosis associated with early jejunal tube feeding: a complication of postoperative enteral nutrition. Arch Surg. 2006;141:701–4.PubMed Melis M, Fichera A, Mk F. Bowel necrosis associated with early jejunal tube feeding: a complication of postoperative enteral nutrition. Arch Surg. 2006;141:701–4.PubMed
20.
go back to reference Marvin RG, McKinley BA, McQuiggan M, Cocanour CS, Fa M. Nonocclusive bowel necrosis occurring in critically ill trauma patients receiving enteral nutrition manifests no reliable clinical signs for early detection. Am J Surg. 2000;179:7–12.PubMed Marvin RG, McKinley BA, McQuiggan M, Cocanour CS, Fa M. Nonocclusive bowel necrosis occurring in critically ill trauma patients receiving enteral nutrition manifests no reliable clinical signs for early detection. Am J Surg. 2000;179:7–12.PubMed
21.
go back to reference Mancl EE. Muzevich KM Tolerability and safety of enteral nutrition in critically ill patients receiving intravenous vasopressor therapy. JPEN J Parenter Enter Nutr. 2013;37:641–51. Mancl EE. Muzevich KM Tolerability and safety of enteral nutrition in critically ill patients receiving intravenous vasopressor therapy. JPEN J Parenter Enter Nutr. 2013;37:641–51.
22.
go back to reference Reignier J, Boisramé-Helms J, Brisard L, Lascarrou JB, Ait Hssain A, Anguel N, et al. NUTRIREA-2 trial investigators; clinical research in intensive care and sepsis (CRICS) group. Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2). Lancet. 2018;391:133–43.PubMed Reignier J, Boisramé-Helms J, Brisard L, Lascarrou JB, Ait Hssain A, Anguel N, et al. NUTRIREA-2 trial investigators; clinical research in intensive care and sepsis (CRICS) group. Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2). Lancet. 2018;391:133–43.PubMed
23.
go back to reference Piton G, Le Gouge A, Brule N, et al. Impact of the route of nutrition on gut mucosa in ventilated adults with shock: an ancillary of the NUTRIREA-2 trial. Intensive Care Med. 2019;45:948–56.PubMed Piton G, Le Gouge A, Brule N, et al. Impact of the route of nutrition on gut mucosa in ventilated adults with shock: an ancillary of the NUTRIREA-2 trial. Intensive Care Med. 2019;45:948–56.PubMed
24.
go back to reference Harvey SE, Parrott F, Harrison DA, Bear DE, Segaran E, Beale R, et al. Trial of the route of early nutritional support in critically ill adults. N Engl J Med. 2014;371:1673–84.PubMed Harvey SE, Parrott F, Harrison DA, Bear DE, Segaran E, Beale R, et al. Trial of the route of early nutritional support in critically ill adults. N Engl J Med. 2014;371:1673–84.PubMed
25.
go back to reference Patel JJ, Kozeniecki M, Peppard WJ, Peppard SR, Zellner-Jones S, Graf J, et al. Phase 3 pilot randomized controlled trial comparing early trophic enteral nutrition with “no enteral nutrition” in mechanically ventilated patients with septic shock. JPEN J Parenter Enter Nutr. 2020;44:866–73. Patel JJ, Kozeniecki M, Peppard WJ, Peppard SR, Zellner-Jones S, Graf J, et al. Phase 3 pilot randomized controlled trial comparing early trophic enteral nutrition with “no enteral nutrition” in mechanically ventilated patients with septic shock. JPEN J Parenter Enter Nutr. 2020;44:866–73.
26.
go back to reference Shah FA, Kitsios GD, Zhang Y, Morris A, Yende S, Huang DT, et al. Design of the study of early enteral dextrose in sepsis: a pilot placebo-controlled randomized clinical trial. JPEN J Parenter Enter Nutr. 2020;44:541–7. Shah FA, Kitsios GD, Zhang Y, Morris A, Yende S, Huang DT, et al. Design of the study of early enteral dextrose in sepsis: a pilot placebo-controlled randomized clinical trial. JPEN J Parenter Enter Nutr. 2020;44:541–7.
27.
go back to reference El-Kersh K, Jalil B, McClave SA, Cavallazzi R, Guardiola J, Guilkey K, et al. Enteral nutrition as stress ulcer prophylaxis in critically ill patients: a randomized controlled exploratory study. J Crit Care. 2018;43:108–13.PubMed El-Kersh K, Jalil B, McClave SA, Cavallazzi R, Guardiola J, Guilkey K, et al. Enteral nutrition as stress ulcer prophylaxis in critically ill patients: a randomized controlled exploratory study. J Crit Care. 2018;43:108–13.PubMed
29.
go back to reference Jalil BA, El-Kersh K. Enteral nutrition better than proton pump inhibitors? Curr Opin Crit Care. 2019;25:334–9.PubMed Jalil BA, El-Kersh K. Enteral nutrition better than proton pump inhibitors? Curr Opin Crit Care. 2019;25:334–9.PubMed
30.
go back to reference Itkin M, DeLegge MH, Fang JC, McClave SA, Kundu S, Janne d’Othee B, et al. Multidisciplinary practical guidelines for gastrointestinal access for enteral nutrition and decompression from the Society of Interventional Radiology and American Gastroenterological Association (AGA) Institute, with endorsement by Canadian Interventional Radiological Association (CIRA) and Cardiovascular and Interventional Radiological Society of Europe (CIRSE). Gastroenterology. 2011;141:742–65.PubMed Itkin M, DeLegge MH, Fang JC, McClave SA, Kundu S, Janne d’Othee B, et al. Multidisciplinary practical guidelines for gastrointestinal access for enteral nutrition and decompression from the Society of Interventional Radiology and American Gastroenterological Association (AGA) Institute, with endorsement by Canadian Interventional Radiological Association (CIRA) and Cardiovascular and Interventional Radiological Society of Europe (CIRSE). Gastroenterology. 2011;141:742–65.PubMed
31.
go back to reference Alkhawaja S, Martin C, Butler RJ, Gwadry-Sridhar F. Post-pyloric versus gastric tube feeding for preventing pneumonia and improving nutritional outcomes in critically ill adults. Cochrane Database Syst Rev. 2015;2015(8):CD008875.PubMedCentral Alkhawaja S, Martin C, Butler RJ, Gwadry-Sridhar F. Post-pyloric versus gastric tube feeding for preventing pneumonia and improving nutritional outcomes in critically ill adults. Cochrane Database Syst Rev. 2015;2015(8):CD008875.PubMedCentral
32.
go back to reference Deane AM, Dhaliwal R, Day AG, Ridley EJ, Davies AR, Heyland DK. Comparisons between intragastric and small intestinal delivery of enteral nutrition in the critically ill: a systematic review and meta-analysis. Crit Care. 2013;17:R125.PubMed Deane AM, Dhaliwal R, Day AG, Ridley EJ, Davies AR, Heyland DK. Comparisons between intragastric and small intestinal delivery of enteral nutrition in the critically ill: a systematic review and meta-analysis. Crit Care. 2013;17:R125.PubMed
34.
go back to reference Needham DM, Dinglas VD, Bienvenu OJ, et al. One year outcomes in patients with acute lung injury randomised to initial trophic or full enteral feeding: prospective follow-up of EDEN randomised trial. BMJ. 2013;346:f1532.PubMedPubMedCentral Needham DM, Dinglas VD, Bienvenu OJ, et al. One year outcomes in patients with acute lung injury randomised to initial trophic or full enteral feeding: prospective follow-up of EDEN randomised trial. BMJ. 2013;346:f1532.PubMedPubMedCentral
35.
go back to reference Needham DM, Dinglas VD, Morris PE, et al. Physical and cognitive performance of acute lung injury patients one year after initial trophic vs full enteral feeding: EDEN trial follow-up. Am J Respir Crit Care Med. 2013;188:567–76.PubMedPubMedCentral Needham DM, Dinglas VD, Morris PE, et al. Physical and cognitive performance of acute lung injury patients one year after initial trophic vs full enteral feeding: EDEN trial follow-up. Am J Respir Crit Care Med. 2013;188:567–76.PubMedPubMedCentral
36.
go back to reference Deane AM, Little L, Bellomo R, et al. Outcomes six months after delivering 100% or 70% of enteral calorie requirements during critical illness (TARGET): a randomized controlled trial. Am J Respir Crit Care Med. 2020;201:814–22.PubMed Deane AM, Little L, Bellomo R, et al. Outcomes six months after delivering 100% or 70% of enteral calorie requirements during critical illness (TARGET): a randomized controlled trial. Am J Respir Crit Care Med. 2020;201:814–22.PubMed
37.
go back to reference Rice TW, Wheeler AP, Thompson BT, et al. Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA. 2012;307:795–803.PubMed Rice TW, Wheeler AP, Thompson BT, et al. Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA. 2012;307:795–803.PubMed
38.
go back to reference Arabi YM, Tamim HM, Dhar GS, Al-dawood A, Al-sultan M, Sakkijha MH, et al. Permissive underfeeding and intensive insulin therapy in critically ill patients : a randomized controlled trial. Am J Clin Nutr. 2011;93:569–77.PubMed Arabi YM, Tamim HM, Dhar GS, Al-dawood A, Al-sultan M, Sakkijha MH, et al. Permissive underfeeding and intensive insulin therapy in critically ill patients : a randomized controlled trial. Am J Clin Nutr. 2011;93:569–77.PubMed
39.
go back to reference Arabi YM, Aldawood AS, Haddad SH, Al-Dorzi HM, Tamim HM, Jones G, et al. Permissive underfeeding or standard enteral feeding in critically ill adults. N Engl J Med. 2015;372:2398–408.PubMed Arabi YM, Aldawood AS, Haddad SH, Al-Dorzi HM, Tamim HM, Jones G, et al. Permissive underfeeding or standard enteral feeding in critically ill adults. N Engl J Med. 2015;372:2398–408.PubMed
40.
go back to reference Chapman M, Peake SL, Bellomo R, et al. Energy-dense versus routine enteral nutrition in the critically ill. N Engl J Med. 2018;379:1823–34.PubMed Chapman M, Peake SL, Bellomo R, et al. Energy-dense versus routine enteral nutrition in the critically ill. N Engl J Med. 2018;379:1823–34.PubMed
41.
go back to reference Doig GS, Simpson F, Heighes PT, Bellomo R, Chesher D, Caterson ID, et al. Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial. Lancet Respir Med. 2015;3:943–52.PubMed Doig GS, Simpson F, Heighes PT, Bellomo R, Chesher D, Caterson ID, et al. Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial. Lancet Respir Med. 2015;3:943–52.PubMed
42.
go back to reference Heyland DK, Dhaliwal R, Jiang X, Day AG. Identifying critically ill patients who benefit the most from nutrition therapy: the development and initial validation of a novel risk assessment tool. Crit Care. 2011;15:R268.PubMedPubMedCentral Heyland DK, Dhaliwal R, Jiang X, Day AG. Identifying critically ill patients who benefit the most from nutrition therapy: the development and initial validation of a novel risk assessment tool. Crit Care. 2011;15:R268.PubMedPubMedCentral
43.
go back to reference Arabi YM, Aldawood AS, Al-Dorzi HM, et al. Permissive underfeeding or standard enteral feeding in high and low nutritional risk critically ill adults: post-hoc analysis of the permit trial. Am J Respir Crit Care Med. 2017;195:652–62.PubMed Arabi YM, Aldawood AS, Al-Dorzi HM, et al. Permissive underfeeding or standard enteral feeding in high and low nutritional risk critically ill adults: post-hoc analysis of the permit trial. Am J Respir Crit Care Med. 2017;195:652–62.PubMed
44.
go back to reference Singer P, De Waele E, Sanchez C, et al. TICACOS international: a multi-center, randomized, prospective controlled study comparing tight calorie control versus Liberal calorie administration study. Clin Nutr. 2021;40:380–7.PubMed Singer P, De Waele E, Sanchez C, et al. TICACOS international: a multi-center, randomized, prospective controlled study comparing tight calorie control versus Liberal calorie administration study. Clin Nutr. 2021;40:380–7.PubMed
45.
go back to reference Allingstrup MJ, Kondrup J, Wiis J, Claudius C, Pedersen UG, Hein-Rasmussen R, et al. Early goal-directed nutrition versus standard of care in adult intensive care patients: the single-centre, randomised, outcome assessor-blinded EAT-ICU trial. Intensive Care Med. 2017;43:1637–47.PubMed Allingstrup MJ, Kondrup J, Wiis J, Claudius C, Pedersen UG, Hein-Rasmussen R, et al. Early goal-directed nutrition versus standard of care in adult intensive care patients: the single-centre, randomised, outcome assessor-blinded EAT-ICU trial. Intensive Care Med. 2017;43:1637–47.PubMed
46.
go back to reference Heidegger CP, Berger MM, Graf S, Zingg W, Darmon P, Costanza MC, et al. Optimisation of energy provision with supplemental parenteral nutrition in critically ill patients: a randomised controlled clinical trial. Lancet. 2013;381:385–93.PubMed Heidegger CP, Berger MM, Graf S, Zingg W, Darmon P, Costanza MC, et al. Optimisation of energy provision with supplemental parenteral nutrition in critically ill patients: a randomised controlled clinical trial. Lancet. 2013;381:385–93.PubMed
47.
go back to reference Casaer MP, Van den Berghe G, Gunst J. Indirect Calorimetry: a faithful guide for nutrition therapy, or a fascinating research tool? Clin Nutr. 2021;40:651.PubMed Casaer MP, Van den Berghe G, Gunst J. Indirect Calorimetry: a faithful guide for nutrition therapy, or a fascinating research tool? Clin Nutr. 2021;40:651.PubMed
48.
go back to reference Van Dyck L, Gunst J, Casaer MP, et al. The clinical potential of GDF15 as a “ready-to-feed indicator” for critically ill adults. Crit Care. 2020;24:557.PubMedPubMedCentral Van Dyck L, Gunst J, Casaer MP, et al. The clinical potential of GDF15 as a “ready-to-feed indicator” for critically ill adults. Crit Care. 2020;24:557.PubMedPubMedCentral
49.
go back to reference Stoppe C, Wendt S, Mehta NM, Compher C, Preiser JC, Heyland DK, et al. Biomarkers in critical care nutrition. Crit Care. 2020;24(1):499.PubMedPubMedCentral Stoppe C, Wendt S, Mehta NM, Compher C, Preiser JC, Heyland DK, et al. Biomarkers in critical care nutrition. Crit Care. 2020;24(1):499.PubMedPubMedCentral
50.
go back to reference Ridley EJ, Parke RL, Davies AR, Bailey M, Hodgson C, Deane AM, et al. What happens to nutrition intake in the post-intensive care unit hospitalization period? An observational cohort study in critically ill adults. J Parenter Enter Nutr. 2019;43:88–95. Ridley EJ, Parke RL, Davies AR, Bailey M, Hodgson C, Deane AM, et al. What happens to nutrition intake in the post-intensive care unit hospitalization period? An observational cohort study in critically ill adults. J Parenter Enter Nutr. 2019;43:88–95.
51.
go back to reference Massanet PL, Petit L, Louart B, Corne P, Richard C, Preiser JC. Nutrition rehabilitation in the intensive care unit. JPEN J Parenter Enteral Nutr. 2015;39:391–400.PubMed Massanet PL, Petit L, Louart B, Corne P, Richard C, Preiser JC. Nutrition rehabilitation in the intensive care unit. JPEN J Parenter Enteral Nutr. 2015;39:391–400.PubMed
52.
go back to reference Peake SL, Chapman MJ, Davies AR, et al. Enteral nutrition in Australia and New Zealand intensive care units: a point-prevalence study of prescription practices. Crit Care Resusc. 2012;14:148–53.PubMed Peake SL, Chapman MJ, Davies AR, et al. Enteral nutrition in Australia and New Zealand intensive care units: a point-prevalence study of prescription practices. Crit Care Resusc. 2012;14:148–53.PubMed
53.
go back to reference Ridley EJ, Peake SL, Jarvis M, et al. Nutrition therapy in Australia and New Zealand intensive care units: an international comparison study. J Parenter Enter Nutr. 2018;42:1349–57. Ridley EJ, Peake SL, Jarvis M, et al. Nutrition therapy in Australia and New Zealand intensive care units: an international comparison study. J Parenter Enter Nutr. 2018;42:1349–57.
54.
go back to reference Preiser JC, Berré J, Carpentier Y, Jolliet P, Pichard C, Van Gossum A, et al. Management of nutrition in European intensive care units: results of a questionnaire. Working group on metabolism and nutrition of the European Society of Intensive Care Medicine. Intensive Care Med. 1999;25:95–101.PubMed Preiser JC, Berré J, Carpentier Y, Jolliet P, Pichard C, Van Gossum A, et al. Management of nutrition in European intensive care units: results of a questionnaire. Working group on metabolism and nutrition of the European Society of Intensive Care Medicine. Intensive Care Med. 1999;25:95–101.PubMed
55.
go back to reference Kar P, Plummer MP, Chapman MJ, et al. Energy-dense formulae may slow gastric emptying in the critically ill. J Parenter Enter Nutr. 2016;40:1050–6. Kar P, Plummer MP, Chapman MJ, et al. Energy-dense formulae may slow gastric emptying in the critically ill. J Parenter Enter Nutr. 2016;40:1050–6.
56.
go back to reference Weijs PJ, Looijaard WG, Dekker IM, Stapel SN, Girbes AR, Oudemans-van Straaten HM, et al. Low skeletal muscle area is a risk factor for mortality in mechanically ventilated critically ill patients. Crit Care. 2014;18:1. Weijs PJ, Looijaard WG, Dekker IM, Stapel SN, Girbes AR, Oudemans-van Straaten HM, et al. Low skeletal muscle area is a risk factor for mortality in mechanically ventilated critically ill patients. Crit Care. 2014;18:1.
57.
go back to reference Gillis C, Carli F. Promoting perioperative metabolic and nutritional care. Anesthesiology. 2015;123:1455–72.PubMed Gillis C, Carli F. Promoting perioperative metabolic and nutritional care. Anesthesiology. 2015;123:1455–72.PubMed
58.
go back to reference Puthucheary ZA, Rawal J, McPhail M, Connolly B, Ratnayake G, Chan P, et al. Acute skeletal muscle wasting in critical illness. JAMA. 2013;310:1591–600.PubMed Puthucheary ZA, Rawal J, McPhail M, Connolly B, Ratnayake G, Chan P, et al. Acute skeletal muscle wasting in critical illness. JAMA. 2013;310:1591–600.PubMed
59.
go back to reference Cresci GA. Protein and aminoacid metabolism: stress versus nonstress states. In: Cresci GA, editor. Nutrition support for the critically ill patient. Boca Raton: Taylor & Francis; 2005. p. 29. Cresci GA. Protein and aminoacid metabolism: stress versus nonstress states. In: Cresci GA, editor. Nutrition support for the critically ill patient. Boca Raton: Taylor & Francis; 2005. p. 29.
60.
go back to reference Weijs PJ, Cynober L, DeLegge M, Kreymann G, Wernerman J, Wolfe RR. Proteins and amino acids are fundamental to optimal nutrition support in critically ill patients. Crit Care. 2014;18:6. Weijs PJ, Cynober L, DeLegge M, Kreymann G, Wernerman J, Wolfe RR. Proteins and amino acids are fundamental to optimal nutrition support in critically ill patients. Crit Care. 2014;18:6.
61.
go back to reference Alberda C, Gramlich L, Jones N, Jeejeebhoy K, Day AG, Dhaliwal R, et al. The relationship between nutritional intake and clinical outcomes in critically ill patients: results of an international multicenter observational study. Intensive Care Med. 2009;35:1728–37.PubMed Alberda C, Gramlich L, Jones N, Jeejeebhoy K, Day AG, Dhaliwal R, et al. The relationship between nutritional intake and clinical outcomes in critically ill patients: results of an international multicenter observational study. Intensive Care Med. 2009;35:1728–37.PubMed
62.
go back to reference Weijs PJM, Mogensen KM, Rawn JD, Christopher KB. Protein intake, nutritional status and outcomes in ICU survivors: a single center cohort study. J Clin Med. 2019;8:43.PubMedCentral Weijs PJM, Mogensen KM, Rawn JD, Christopher KB. Protein intake, nutritional status and outcomes in ICU survivors: a single center cohort study. J Clin Med. 2019;8:43.PubMedCentral
63.
go back to reference Wischmeyer PE, Hasselmann M, Kummerlen C, Kozar R, Kutsogiannis DJ, Karvellas CJ, et al. A randomized trial of supplemental parenteral nutrition in underweight and overweight critically ill patients: the TOP-UP pilot trial. Crit Care. 2017;21:142.PubMedPubMedCentral Wischmeyer PE, Hasselmann M, Kummerlen C, Kozar R, Kutsogiannis DJ, Karvellas CJ, et al. A randomized trial of supplemental parenteral nutrition in underweight and overweight critically ill patients: the TOP-UP pilot trial. Crit Care. 2017;21:142.PubMedPubMedCentral
64.
go back to reference Yeh DD, Fuentes E, Quraishi SA, Cropano C, Kaafarani H, Lee J, et al. Adequate nutrition may get you home: effect of caloric/protein deficits on the discharge destination of critically ill surgical patients. JPEN J Parenter Enter Nutr. 2016;40:37–44. Yeh DD, Fuentes E, Quraishi SA, Cropano C, Kaafarani H, Lee J, et al. Adequate nutrition may get you home: effect of caloric/protein deficits on the discharge destination of critically ill surgical patients. JPEN J Parenter Enter Nutr. 2016;40:37–44.
65.
go back to reference Mitchell A, Clemente R, Downer C, Greer F, Allan K, Collinson A, et al. Protein provision in critically ill adults requiring enteral nutrition: are guidelines being met? Nutr Clin Pract. 2019;34:123–30.PubMed Mitchell A, Clemente R, Downer C, Greer F, Allan K, Collinson A, et al. Protein provision in critically ill adults requiring enteral nutrition: are guidelines being met? Nutr Clin Pract. 2019;34:123–30.PubMed
66.
go back to reference De Waele E, Jakubowski JR, Stocker R, Pe W. Review of evolution and current status of protein requirements and provision in acute illness and critical care. Clin Nutr. 2021;40:2958–73.PubMed De Waele E, Jakubowski JR, Stocker R, Pe W. Review of evolution and current status of protein requirements and provision in acute illness and critical care. Clin Nutr. 2021;40:2958–73.PubMed
67.
68.
go back to reference Weijs PJM, Stapel SN, de Groot SDW, Driessen RH, de Jong E, Girbes ARJ, et al. Optimal protein and energy nutrition decreases mortality in mechanically ventilated, critically ill patients. J Parenter Enter Nutr. 2012;36:60–8. Weijs PJM, Stapel SN, de Groot SDW, Driessen RH, de Jong E, Girbes ARJ, et al. Optimal protein and energy nutrition decreases mortality in mechanically ventilated, critically ill patients. J Parenter Enter Nutr. 2012;36:60–8.
69.
go back to reference Wei X, Day AG, Ouellette-Kuntz H, Heyland DK. The association between nutritional adequacy and long-term outcomes in critically ill patients requiring prolonged mechanical ventilation: a multicenter cohort study. Crit Care Med. 2015;43:1569–79.PubMed Wei X, Day AG, Ouellette-Kuntz H, Heyland DK. The association between nutritional adequacy and long-term outcomes in critically ill patients requiring prolonged mechanical ventilation: a multicenter cohort study. Crit Care Med. 2015;43:1569–79.PubMed
70.
go back to reference Nicolo M, Heyland DK, Chittams J, Sammarco T, Compher C. Clinical outcomes related to protein delivery in a critically ill population. J Parenter Enter Nutr. 2016;40:45–51. Nicolo M, Heyland DK, Chittams J, Sammarco T, Compher C. Clinical outcomes related to protein delivery in a critically ill population. J Parenter Enter Nutr. 2016;40:45–51.
71.
go back to reference Compher C, Chittams J, Sammarco T, Nicolo M, Heyland DK. Greater protein and energy intake may be associated with improved mortality in higher risk critically ill patients: a multicenter. Multinatl Observ Study Crit Care Med. 2017;45:156–63. Compher C, Chittams J, Sammarco T, Nicolo M, Heyland DK. Greater protein and energy intake may be associated with improved mortality in higher risk critically ill patients: a multicenter. Multinatl Observ Study Crit Care Med. 2017;45:156–63.
72.
go back to reference Zusman O, Theilla M, Cohen J, Kagan I, Bendavid I, Singer P. Resting energy expenditure, calorie and protein consumption in critically ill patients: a retrospective cohort study. Crit Care. 2016;20:367.PubMedPubMedCentral Zusman O, Theilla M, Cohen J, Kagan I, Bendavid I, Singer P. Resting energy expenditure, calorie and protein consumption in critically ill patients: a retrospective cohort study. Crit Care. 2016;20:367.PubMedPubMedCentral
73.
go back to reference Elke G, Wang M, Weiler N, Day AG, Dk H. Close to recommended caloric and protein intake by enteral nutrition is associated with better clinical outcome of critically ill septic patients: secondary analysis of a large international nutrition database. Crit Care. 2014;18:R29.PubMedPubMedCentral Elke G, Wang M, Weiler N, Day AG, Dk H. Close to recommended caloric and protein intake by enteral nutrition is associated with better clinical outcome of critically ill septic patients: secondary analysis of a large international nutrition database. Crit Care. 2014;18:R29.PubMedPubMedCentral
74.
go back to reference Allingstrup MJ, Esmailzadeh N, Wilkens Knudsen A, Espersen K, Hartvig Jensen T, Wiis J, et al. Provision of protein and energy in relation to measured requirements in intensive care patients. Clin Nutr. 2012;31:462–8.PubMed Allingstrup MJ, Esmailzadeh N, Wilkens Knudsen A, Espersen K, Hartvig Jensen T, Wiis J, et al. Provision of protein and energy in relation to measured requirements in intensive care patients. Clin Nutr. 2012;31:462–8.PubMed
75.
go back to reference Hoffer LJ, Bistrian BR. Appropriate protein provision in critical illness: a systematic and narrative review. Am J Clin Nutr. 2012;96(3):591–600.PubMed Hoffer LJ, Bistrian BR. Appropriate protein provision in critical illness: a systematic and narrative review. Am J Clin Nutr. 2012;96(3):591–600.PubMed
76.
go back to reference Tagawa R, Watanabe D, Ito K, Ueda K, Nakayama K, Sanbongi C, et al. Dose-response relationship between protein intake and muscle mass increase: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev. 2020;79:66–75.PubMedCentral Tagawa R, Watanabe D, Ito K, Ueda K, Nakayama K, Sanbongi C, et al. Dose-response relationship between protein intake and muscle mass increase: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev. 2020;79:66–75.PubMedCentral
77.
go back to reference Ferrie S, Allman-Farinelli M, Daley M, Smith K. Protein requirements in the critically ill: a randomized controlled trial using parenteral nutrition. JPEN J Parenter Enteral Nutr. 2016;40:795–805.PubMed Ferrie S, Allman-Farinelli M, Daley M, Smith K. Protein requirements in the critically ill: a randomized controlled trial using parenteral nutrition. JPEN J Parenter Enteral Nutr. 2016;40:795–805.PubMed
78.
go back to reference Caparros T, Lopez J, Grau T. Early enteral nutrition in critically ill patients with a high-protein diet enriched with arginine, fiber, and antioxidants compared with a standard high-protein diet. The effect on nosocomial infections and outcome. JPEN J Parenter Enter Nutr. 2001;25:299–308. Caparros T, Lopez J, Grau T. Early enteral nutrition in critically ill patients with a high-protein diet enriched with arginine, fiber, and antioxidants compared with a standard high-protein diet. The effect on nosocomial infections and outcome. JPEN J Parenter Enter Nutr. 2001;25:299–308.
79.
go back to reference Rugeles S, Villarraga-Angulo LG, Ariza-Gutiérrez A, Chaverra-Kornerup S, Lasalvia P, Rosselli D. High-protein hypocaloric vs normocaloric enteral nutrition in critically ill patients: a randomized clinical trial. J Crit Care. 2016;35:110–4.PubMed Rugeles S, Villarraga-Angulo LG, Ariza-Gutiérrez A, Chaverra-Kornerup S, Lasalvia P, Rosselli D. High-protein hypocaloric vs normocaloric enteral nutrition in critically ill patients: a randomized clinical trial. J Crit Care. 2016;35:110–4.PubMed
80.
go back to reference Scheinkestel CD, Kar L, Marshall K, Bailey M, Davies A, Nyulasi I, et al. Prospective randomized trial to assess caloric and protein needs of critically Ill, anuric, ventilated patients requiring continuous renal replacement therapy. Nutrition. 2003;19:909–16.PubMed Scheinkestel CD, Kar L, Marshall K, Bailey M, Davies A, Nyulasi I, et al. Prospective randomized trial to assess caloric and protein needs of critically Ill, anuric, ventilated patients requiring continuous renal replacement therapy. Nutrition. 2003;19:909–16.PubMed
81.
go back to reference Doig GS, Simpson F, Bellomo R, Heighes PT, Sweetman EA, Chesher D, et al. Intravenous amino acid therapy for kidney function in critically ill patients: a randomized controlled trial. Intensive Care Med. 2015;41:1197–208.PubMed Doig GS, Simpson F, Bellomo R, Heighes PT, Sweetman EA, Chesher D, et al. Intravenous amino acid therapy for kidney function in critically ill patients: a randomized controlled trial. Intensive Care Med. 2015;41:1197–208.PubMed
82.
go back to reference Davies ML, Chapple LS, Chapman MJ, Moran JL, Peake SL. Protein delivery and clinical outcomes in the critically ill: a systematic review and meta-analysis. Crit Care Resusc. 2017;19:117–27.PubMed Davies ML, Chapple LS, Chapman MJ, Moran JL, Peake SL. Protein delivery and clinical outcomes in the critically ill: a systematic review and meta-analysis. Crit Care Resusc. 2017;19:117–27.PubMed
83.
go back to reference Fetterplace K, Gill BMT, Chapple LS, Presneill JJ, MacIsaac C, Deane AM. Systematic review with meta-analysis of patient-centered outcomes, comparing international guideline-recommended enteral protein delivery with usual care. JPEN J Parenter Enter Nutr. 2020;44:610–20. Fetterplace K, Gill BMT, Chapple LS, Presneill JJ, MacIsaac C, Deane AM. Systematic review with meta-analysis of patient-centered outcomes, comparing international guideline-recommended enteral protein delivery with usual care. JPEN J Parenter Enter Nutr. 2020;44:610–20.
84.
go back to reference Casaer MP, Mesotten D, Hermans G, Wouters PJ, Schetz M, Meyfroidt G, et al. Early versus late parenteral nutrition in critically ill adults. N Engl J Med. 2011;365:506–17.PubMed Casaer MP, Mesotten D, Hermans G, Wouters PJ, Schetz M, Meyfroidt G, et al. Early versus late parenteral nutrition in critically ill adults. N Engl J Med. 2011;365:506–17.PubMed
85.
go back to reference Casaer MP, Wilmer A, Hermans G, Wouters PJ, Mesotten D. Role of disease and macronutrient dose in the randomized controlled EPaNIC trial: a post hoc analysis. Am J Respir Crit Care Med. 2013;187:247–55.PubMed Casaer MP, Wilmer A, Hermans G, Wouters PJ, Mesotten D. Role of disease and macronutrient dose in the randomized controlled EPaNIC trial: a post hoc analysis. Am J Respir Crit Care Med. 2013;187:247–55.PubMed
86.
go back to reference Vanhorebeek I, Verbruggen S, Casaer MP, Gunst J, Wouters PJ, Hanot J, et al. Effect of early supplemental parenteral nutrition in the paediatric ICU: a preplanned observational study of post-randomisation treatments in the PEPaNIC trial. Lancet Respir Med. 2017;5:475–83.PubMed Vanhorebeek I, Verbruggen S, Casaer MP, Gunst J, Wouters PJ, Hanot J, et al. Effect of early supplemental parenteral nutrition in the paediatric ICU: a preplanned observational study of post-randomisation treatments in the PEPaNIC trial. Lancet Respir Med. 2017;5:475–83.PubMed
87.
go back to reference Koekkoek W, van Setten C, Olthof LE, Kars J, van Zanten ARH. Timing of PROTein INtake and clinical outcomes of adult critically ill patients on prolonged mechanical VENTilation: The PROTINVENT retrospective study. Clin Nutr. 2019;38:883–90.PubMed Koekkoek W, van Setten C, Olthof LE, Kars J, van Zanten ARH. Timing of PROTein INtake and clinical outcomes of adult critically ill patients on prolonged mechanical VENTilation: The PROTINVENT retrospective study. Clin Nutr. 2019;38:883–90.PubMed
88.
go back to reference Badjatia N, Sanchez S, Judd G, Hausladen R, Hering D, Motta M, et al. Neuromuscular electrical stimulation and high-protein supplementation after subarachnoid hemorrhage: a single-center phase 2 randomized clinical trial. Neurocrit Care. 2021;35:46–55.PubMed Badjatia N, Sanchez S, Judd G, Hausladen R, Hering D, Motta M, et al. Neuromuscular electrical stimulation and high-protein supplementation after subarachnoid hemorrhage: a single-center phase 2 randomized clinical trial. Neurocrit Care. 2021;35:46–55.PubMed
89.
go back to reference Heyland DK, Day A, John Clarke G, Hough C, Clark Files D, Mourtzakis M, et al. Nutrition and Exercise in Critical Illness Trial (NEXIS Trial): a protocol of a multicentred, randomised controlled trial of combined cycle ergometry and amino acid supplementation commenced early during critical illness. BMJ Open. 2019;9:27893. Heyland DK, Day A, John Clarke G, Hough C, Clark Files D, Mourtzakis M, et al. Nutrition and Exercise in Critical Illness Trial (NEXIS Trial): a protocol of a multicentred, randomised controlled trial of combined cycle ergometry and amino acid supplementation commenced early during critical illness. BMJ Open. 2019;9:27893.
90.
go back to reference Van Zanten ARH, De Waele E, Wischmeyer PE. Nutrition therapy and critical illness: practical guidance for the ICU, post-icu, and long-term convalescence phases. Crit Care. 2019;23:368.PubMedPubMedCentral Van Zanten ARH, De Waele E, Wischmeyer PE. Nutrition therapy and critical illness: practical guidance for the ICU, post-icu, and long-term convalescence phases. Crit Care. 2019;23:368.PubMedPubMedCentral
91.
go back to reference Heyland D, Muscedere J, Wischmeyer PE, Cook D, Jones G, Albert M, et al. A randomized trial of glutamine and antioxidants in critically ill patients. N Engl J Med. 2013;368:1489–97.PubMed Heyland D, Muscedere J, Wischmeyer PE, Cook D, Jones G, Albert M, et al. A randomized trial of glutamine and antioxidants in critically ill patients. N Engl J Med. 2013;368:1489–97.PubMed
92.
go back to reference Viana MV, Becce F, Pantet O, et al. Impact of β-hydroxy-β-methylbutyrate (HMB) on muscle loss and protein metabolism in critically ill patients: a RCT. Clin Nutr. 2021;40:4878–87.PubMed Viana MV, Becce F, Pantet O, et al. Impact of β-hydroxy-β-methylbutyrate (HMB) on muscle loss and protein metabolism in critically ill patients: a RCT. Clin Nutr. 2021;40:4878–87.PubMed
93.
go back to reference Shenkin A. Functions and deficiency states of trace elements and vitamins. In: Sobotka editor. Basics Clin Nutr ESPEN. Prague: Galen; 2019. p. 123–33. Shenkin A. Functions and deficiency states of trace elements and vitamins. In: Sobotka editor. Basics Clin Nutr ESPEN. Prague: Galen; 2019. p. 123–33.
94.
go back to reference Gombart AF, Pierre A, Maggini SA. Review of micronutrients and the immune system-working in harmony to reduce the risk of infection. Nutrients. 2020;12:236.PubMedCentral Gombart AF, Pierre A, Maggini SA. Review of micronutrients and the immune system-working in harmony to reduce the risk of infection. Nutrients. 2020;12:236.PubMedCentral
95.
go back to reference Berger MM, Pantet O, Schneider A, Ben-Hamouda N. Micronutrient deficiencies in medical and surgical inpatients. J Clin Med. 2019;8:931.PubMedCentral Berger MM, Pantet O, Schneider A, Ben-Hamouda N. Micronutrient deficiencies in medical and surgical inpatients. J Clin Med. 2019;8:931.PubMedCentral
96.
go back to reference Wesselink E, Wac K, Grefte S, Witkamp RF, van Zanten ARH. Feeding mitochondria: potential role of nutritional components to improve critical illness convalescence. Clin Nutr. 2019;38:982–95.PubMed Wesselink E, Wac K, Grefte S, Witkamp RF, van Zanten ARH. Feeding mitochondria: potential role of nutritional components to improve critical illness convalescence. Clin Nutr. 2019;38:982–95.PubMed
97.
go back to reference Berger MM, Ben-Hamouda N. Trace element and vitamin deficiency: quantum medicine or essential prescription? Curr Opin Crit Care. 2020;26:355–62.PubMed Berger MM, Ben-Hamouda N. Trace element and vitamin deficiency: quantum medicine or essential prescription? Curr Opin Crit Care. 2020;26:355–62.PubMed
98.
go back to reference Wiesen P, Van Overmeire L, Delanaye P, Dubois B, Preiser J-C. Nutrition disorders during acute renal failure and renal replacement therapy. JPEN J Parenter Enteral Nutr. 2011;35:217–22.PubMed Wiesen P, Van Overmeire L, Delanaye P, Dubois B, Preiser J-C. Nutrition disorders during acute renal failure and renal replacement therapy. JPEN J Parenter Enteral Nutr. 2011;35:217–22.PubMed
99.
go back to reference Berger MM, Broman M, Forni L, Osterman M, De Waele E, Wischmeyer PE. Nutrients and micronutrients at risk during renal replacement therapy: a scoping review. Curr Opin Crit Care. 2021;2021:26. Berger MM, Broman M, Forni L, Osterman M, De Waele E, Wischmeyer PE. Nutrients and micronutrients at risk during renal replacement therapy: a scoping review. Curr Opin Crit Care. 2021;2021:26.
100.
go back to reference Viana MV, Pantet O, Bagnoud G, Martinez A, Favre E, Charriere M, et al. Metabolic and nutritional characteristics of long-stay critically ill patients. J Clin Med. 2019;8:985.PubMedCentral Viana MV, Pantet O, Bagnoud G, Martinez A, Favre E, Charriere M, et al. Metabolic and nutritional characteristics of long-stay critically ill patients. J Clin Med. 2019;8:985.PubMedCentral
101.
go back to reference Vankrunkelsven W, Gunst J, Amrein K, Bear DE, Berger MM, Christopher KB, et al. Monitoring and parenteral administration of micronutrients, phosphate and magnesium in critically ill patients: The VITA-TRACE Survey. Clin Nutr. 2021;40:590–9.PubMed Vankrunkelsven W, Gunst J, Amrein K, Bear DE, Berger MM, Christopher KB, et al. Monitoring and parenteral administration of micronutrients, phosphate and magnesium in critically ill patients: The VITA-TRACE Survey. Clin Nutr. 2021;40:590–9.PubMed
102.
go back to reference Azoulay E, Vincent JL, Angus DC, Arabi YM, Brochard L, Brett SJ, Dos Santos CC, et al. Recovery after critical illness: putting the puzzle together-a consensus of 29. Crit Care. 2017;21:296.PubMedPubMedCentral Azoulay E, Vincent JL, Angus DC, Arabi YM, Brochard L, Brett SJ, Dos Santos CC, et al. Recovery after critical illness: putting the puzzle together-a consensus of 29. Crit Care. 2017;21:296.PubMedPubMedCentral
103.
go back to reference Institute of Medicine Standing CI. Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. In: Washington: US NAP. (DC); 1998. Institute of Medicine Standing CI. Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. In: Washington: US NAP. (DC); 1998.
104.
go back to reference Brannon PM, Weaver CM, Anderson CA, Donovan SM, Murphy SP. Scanning for new evidence to prioritize updates to the dietary reference intakes: case studies for thiamin and phosphorus. Am J Clin Nutr. 2016;104:1366–77.PubMed Brannon PM, Weaver CM, Anderson CA, Donovan SM, Murphy SP. Scanning for new evidence to prioritize updates to the dietary reference intakes: case studies for thiamin and phosphorus. Am J Clin Nutr. 2016;104:1366–77.PubMed
105.
go back to reference Casaer MP, Bellomo R. Micronutrient deficiency in critical illness: an invisible foe? Intensive Care Med. 2019;45:1136–9.PubMed Casaer MP, Bellomo R. Micronutrient deficiency in critical illness: an invisible foe? Intensive Care Med. 2019;45:1136–9.PubMed
106.
go back to reference Berger MM, Soguel L, Schindler C, Revelly JP. Antioxidant supplements modulate clinical course after complex cardiac surgery—preliminary data. Clin Nutr. 2004;23:825. Berger MM, Soguel L, Schindler C, Revelly JP. Antioxidant supplements modulate clinical course after complex cardiac surgery—preliminary data. Clin Nutr. 2004;23:825.
107.
go back to reference Preiser JC. Oxidative stress. JPEN J Parenter Enteral Nutr. 2012;36:147–54.PubMed Preiser JC. Oxidative stress. JPEN J Parenter Enteral Nutr. 2012;36:147–54.PubMed
108.
go back to reference van Zanten ARH. Nutritional support and refeeding syndrome in critical illness. Lancet Respir Med. 2015;3:904–5.PubMed van Zanten ARH. Nutritional support and refeeding syndrome in critical illness. Lancet Respir Med. 2015;3:904–5.PubMed
109.
go back to reference Koekkoek WAC, Van Zanten ARH. Is refeeding syndrome relevant for critically ill patients? Curr Opin Clin Nutr Metab Care. 2018;21:130–7.PubMed Koekkoek WAC, Van Zanten ARH. Is refeeding syndrome relevant for critically ill patients? Curr Opin Clin Nutr Metab Care. 2018;21:130–7.PubMed
110.
go back to reference Boot R, Kwac K, van Zanten ARH. Refeeding syndrome relevance for the critically ill patient. Curr Opin Crit Care. 2018;24:235–40.PubMed Boot R, Kwac K, van Zanten ARH. Refeeding syndrome relevance for the critically ill patient. Curr Opin Crit Care. 2018;24:235–40.PubMed
111.
go back to reference Reintam Blaser A, van Zanten ARH. Electrolyte disorders during the initiation of nutrition therapy in the ICU. Curr Opin Clin Nutr Metab Care Mar. 2021;1:151–8. Reintam Blaser A, van Zanten ARH. Electrolyte disorders during the initiation of nutrition therapy in the ICU. Curr Opin Clin Nutr Metab Care Mar. 2021;1:151–8.
112.
go back to reference Reintam Blaser A, Gunst J, Ichai C, et al. Hypophosphatemia in critically ill adults and children—a systematic review. Clin Nutr. 2021;40:1744–54.PubMed Reintam Blaser A, Gunst J, Ichai C, et al. Hypophosphatemia in critically ill adults and children—a systematic review. Clin Nutr. 2021;40:1744–54.PubMed
113.
go back to reference Berger MM, Appelberg O, Reintam-Blaser A, et al. Prevalence of hypophosphatemia in the ICU—results of an international one-day point prevalence survey. Clin Nutr. 2021;40:3615–21.PubMed Berger MM, Appelberg O, Reintam-Blaser A, et al. Prevalence of hypophosphatemia in the ICU—results of an international one-day point prevalence survey. Clin Nutr. 2021;40:3615–21.PubMed
114.
go back to reference Olthof LE, Koekkoek WACK, van Setten C, Kars JCN, van Blokland D, van Zanten ARH. Impact of caloric intake in critically ill patients with, and without, refeeding syndrome: a retrospective study. Clin Nutr. 2018;37:1609–17.PubMed Olthof LE, Koekkoek WACK, van Setten C, Kars JCN, van Blokland D, van Zanten ARH. Impact of caloric intake in critically ill patients with, and without, refeeding syndrome: a retrospective study. Clin Nutr. 2018;37:1609–17.PubMed
115.
go back to reference Doig GS, Simpson F, Heighes PT, Bellomo R, Chesher D, Caterson ID, Harrigan PW, et al. Refeeding Syndrome Trial Investigators Group. Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial. Lancet Respir Med. 2015;3:943–52.PubMed Doig GS, Simpson F, Heighes PT, Bellomo R, Chesher D, Caterson ID, Harrigan PW, et al. Refeeding Syndrome Trial Investigators Group. Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial. Lancet Respir Med. 2015;3:943–52.PubMed
116.
go back to reference Mehanna HM, Moledina J, Travis J. Refeeding syndrome: what it is, and how to prevent and treat it. BMJ. 2008;336:1495–8.PubMedPubMedCentral Mehanna HM, Moledina J, Travis J. Refeeding syndrome: what it is, and how to prevent and treat it. BMJ. 2008;336:1495–8.PubMedPubMedCentral
118.
go back to reference McClave SA, Gualdoni J, Nagengast A, Marsano LS, Bandy K, Martindale RG. Gastrointestinal dysfunction and feeding intolerance do we need an objective scoring system? Curr Gastroenterol Rep. 2020;22:1.PubMed McClave SA, Gualdoni J, Nagengast A, Marsano LS, Bandy K, Martindale RG. Gastrointestinal dysfunction and feeding intolerance do we need an objective scoring system? Curr Gastroenterol Rep. 2020;22:1.PubMed
119.
go back to reference Reintam Blaser A, Starkopf J, Kirsimagi U, Deane AM. Definition, prevalence, and outcome of feeding intolerance in intensive care: a systematic review and meta-analysis. Acta Anaesthesiol Scand. 2014;58(8):914–22.PubMed Reintam Blaser A, Starkopf J, Kirsimagi U, Deane AM. Definition, prevalence, and outcome of feeding intolerance in intensive care: a systematic review and meta-analysis. Acta Anaesthesiol Scand. 2014;58(8):914–22.PubMed
120.
go back to reference Arabi YM, Reintam Blaser A, Preiser J-C. When and how to manage enteral feeding intolerance? Intensive Care Med. 2019;45:1029–31.PubMed Arabi YM, Reintam Blaser A, Preiser J-C. When and how to manage enteral feeding intolerance? Intensive Care Med. 2019;45:1029–31.PubMed
121.
go back to reference Heyland DK, Ortiz A, Stoppe C, Patel JJ, Yeh DD, Dukes G, et al. Incidence, risk factors, and clinical consequence of enteral feeding intolerance in the mechanically ventilated critically ill: an analysis of a multicenter. Multiyear Database Crit Care Med. 2021;49:59. Heyland DK, Ortiz A, Stoppe C, Patel JJ, Yeh DD, Dukes G, et al. Incidence, risk factors, and clinical consequence of enteral feeding intolerance in the mechanically ventilated critically ill: an analysis of a multicenter. Multiyear Database Crit Care Med. 2021;49:59.
122.
go back to reference Gungabissoon U, Hacquoil K, Bains C, Irizarry M, Dukes G, Williamson R, et al. Prevalence, risk factors, clinical consequences, and treatment of enteral feed intolerance during critical illness. JPEN J Parenter Enter Nutr. 2015;39:41–448. Gungabissoon U, Hacquoil K, Bains C, Irizarry M, Dukes G, Williamson R, et al. Prevalence, risk factors, clinical consequences, and treatment of enteral feed intolerance during critical illness. JPEN J Parenter Enter Nutr. 2015;39:41–448.
123.
go back to reference Hu B, Sun R, Wu A, Ni Y, Liu J, Guo F, et al. Severity of acute gastrointestinal injury grade is a predictor of all-cause mortality in critically ill patients: a multicenter, prospective, observational study. Crit Care. 2017;21:188.PubMedPubMedCentral Hu B, Sun R, Wu A, Ni Y, Liu J, Guo F, et al. Severity of acute gastrointestinal injury grade is a predictor of all-cause mortality in critically ill patients: a multicenter, prospective, observational study. Crit Care. 2017;21:188.PubMedPubMedCentral
124.
go back to reference Reintam Blaser A, Malbrain ML, Starkopf J, Fruhwald S, Jakob SM, De Waele J, et al. Gastrointestinal function in intensive care patients: terminology, definitions and management. Recommendations of the ESICM working group on abdominal problems. Intensive Care Med. 2012;38:384–94.PubMedPubMedCentral Reintam Blaser A, Malbrain ML, Starkopf J, Fruhwald S, Jakob SM, De Waele J, et al. Gastrointestinal function in intensive care patients: terminology, definitions and management. Recommendations of the ESICM working group on abdominal problems. Intensive Care Med. 2012;38:384–94.PubMedPubMedCentral
125.
go back to reference Montejo JC. Enteral nutrition-related gastrointestinal complications in critically ill patients: a multicenter study. Nutr Metab Work Gr Spanish Soc Intensive Care Med Coron Units Crit Care Med. 1999;27:1447–53. Montejo JC. Enteral nutrition-related gastrointestinal complications in critically ill patients: a multicenter study. Nutr Metab Work Gr Spanish Soc Intensive Care Med Coron Units Crit Care Med. 1999;27:1447–53.
126.
go back to reference Elke G, Felbinger TW. Gastric residual volume in critically ill patients: a dead marker or still alive? Nutr Clin Pract. 2015;30:59–71.PubMed Elke G, Felbinger TW. Gastric residual volume in critically ill patients: a dead marker or still alive? Nutr Clin Pract. 2015;30:59–71.PubMed
127.
go back to reference Reignier J, Mercier E, Le Gouge A, Boulain T, Desachy A, Bellec F, et al. Effect of not monitoring residual gastric volume on risk of ventilator-associated pneumonia in adults receiving mechanical ventilation and early enteral feeding: a randomized controlled trial. JAMA. 2013;309:249–56.PubMed Reignier J, Mercier E, Le Gouge A, Boulain T, Desachy A, Bellec F, et al. Effect of not monitoring residual gastric volume on risk of ventilator-associated pneumonia in adults receiving mechanical ventilation and early enteral feeding: a randomized controlled trial. JAMA. 2013;309:249–56.PubMed
129.
go back to reference Montejo JC, Minambres E, Bordeje L, Mesejo A, Acosta J, Heras A, et al. Gastric residual volume during enteral nutrition in ICU patients: the REGANE study. Intensive Care Med. 2010;36:1386–93.PubMed Montejo JC, Minambres E, Bordeje L, Mesejo A, Acosta J, Heras A, et al. Gastric residual volume during enteral nutrition in ICU patients: the REGANE study. Intensive Care Med. 2010;36:1386–93.PubMed
130.
go back to reference McClave SA, Lukan JK, Stefater JA, Lowen CC, Looney SW, Matheson PJ, et al. Poor validity of residual volumes as a marker for risk of aspiration in critically ill patients. Crit Care Med. 2005;33:324–30.PubMed McClave SA, Lukan JK, Stefater JA, Lowen CC, Looney SW, Matheson PJ, et al. Poor validity of residual volumes as a marker for risk of aspiration in critically ill patients. Crit Care Med. 2005;33:324–30.PubMed
131.
go back to reference Reintam Blaser A, Padar M, Mändul M, et al. Development of the Gastrointestinal Dysfunction Score (GIDS) for critically ill patients—a prospective multicenter observational study (iSOFA study). Clin Nutr. 2021;40:4932–40.PubMed Reintam Blaser A, Padar M, Mändul M, et al. Development of the Gastrointestinal Dysfunction Score (GIDS) for critically ill patients—a prospective multicenter observational study (iSOFA study). Clin Nutr. 2021;40:4932–40.PubMed
132.
go back to reference Metheny NA, Mills AC. Monitoring for intolerance to gastric tube feedings: a national survey. Am J Crit Care. 2012;21:33–40. Metheny NA, Mills AC. Monitoring for intolerance to gastric tube feedings: a national survey. Am J Crit Care. 2012;21:33–40.
133.
go back to reference Heinonen T, Ferrie S, Ferguson C. Gut function in the intensive care unit—What is “normal”? Aust Crit Care. 2020;33:151–4.PubMed Heinonen T, Ferrie S, Ferguson C. Gut function in the intensive care unit—What is “normal”? Aust Crit Care. 2020;33:151–4.PubMed
134.
go back to reference Lewis K, Alqahtani Z, McIntyre L, Almenawer S, Alshamsi F, Rhodes A, et al. The efficacy and safety of prokinetic agents in critically ill patients receiving enteral nutrition: a systematic review and meta-analysis of randomized trials. Crit Care. 2016;20:259.PubMedPubMedCentral Lewis K, Alqahtani Z, McIntyre L, Almenawer S, Alshamsi F, Rhodes A, et al. The efficacy and safety of prokinetic agents in critically ill patients receiving enteral nutrition: a systematic review and meta-analysis of randomized trials. Crit Care. 2016;20:259.PubMedPubMedCentral
135.
go back to reference Reintam Blaser A, Deane AM, Preiser JC, Arabi YM. Enteral feeding intolerance: updates in definitions and pathophysiology. Nutr Clin Pract. 2021;36:40–9.PubMed Reintam Blaser A, Deane AM, Preiser JC, Arabi YM. Enteral feeding intolerance: updates in definitions and pathophysiology. Nutr Clin Pract. 2021;36:40–9.PubMed
136.
go back to reference Reintam Blaser A, Preiser JC, Fruhwald S, Wilmer A, Wernerman J, Benstoem C, et al. Gastrointestinal dysfunction in the critically ill: a systematic scoping review and research agenda proposed by the section of metabolism, endocrinology and nutrition of the European Society of Intensive Care Medicine. Crit Care. 2020;24:224.PubMedPubMedCentral Reintam Blaser A, Preiser JC, Fruhwald S, Wilmer A, Wernerman J, Benstoem C, et al. Gastrointestinal dysfunction in the critically ill: a systematic scoping review and research agenda proposed by the section of metabolism, endocrinology and nutrition of the European Society of Intensive Care Medicine. Crit Care. 2020;24:224.PubMedPubMedCentral
Metadata
Title
A guide to enteral nutrition in intensive care units: 10 expert tips for the daily practice
Authors
Jean-Charles Preiser
Yaseen M. Arabi
Mette M. Berger
Michael Casaer
Stephen McClave
Juan C. Montejo-González
Sandra Peake
Annika Reintam Blaser
Greet Van den Berghe
Arthur van Zanten
Jan Wernerman
Paul Wischmeyer
Publication date
01-12-2021
Publisher
BioMed Central
Keyword
Nutrition
Published in
Critical Care / Issue 1/2021
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-021-03847-4

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