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Diagnostic Pathology

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Open Access 01-12-2015 | Short report

NUT expression in primary lung tumours

Authors: Marius Lund-Iversen, Krystyna Kotanska Grøholt, Åslaug Helland, Elin Borgen, Odd Terje Brustugun

Published in: Diagnostic Pathology | Issue 1/2015

Abstract

Background

Nuclear protein in testis (NUT) midline carcinomas (NMC) are rare, highly aggressive epithelial neoplasms, characterised by protein expression of NUT-fusion proteins which reflects the genetic translocation between chromosome 15 and 19. NMC occurs mainly in midline structures, but there are reports regarding occurrence in structures outside the midline.

We investigated specimens from 519 surgically resected lung carcinomas and carcinoid tumours for the presence of NUT protein using immunohistochemistry. Normal testis and two previously confirmed NMCs served as positive controls.

Findings

All 483 evaluable cases (278 adenocarcinomas, 140 squamous cell carcinomas, 30 large cell carcinomas, 7 small cell carcinomas, 10 undifferentiated carcinomas and 18 carcinoids) were completely negative for expression of NUT protein.

Conclusion

NUT gene rearrangement does not seem to be relevant in primary pulmonary carcinomas or carcinoid tumours of the lung.

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Title: NUT expression in primary lung tumours
Authors: Marius Lund-Iversen
Krystyna Kotanska Grøholt
Åslaug Helland
Elin Borgen
Odd Terje Brustugun
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: Diagnostic Pathology / Issue 1/2015
Electronic ISSN: 1746-1596
DOI: https://doi.org/10.1186/s13000-015-0395-9

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Springer Medicine

NUT expression in primary lung tumours

Abstract

Background

Findings

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Findings

Conclusion

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