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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 12/2008

01-12-2008 | Review Article

Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers

Authors: Fabien Chauveau, Hervé Boutin, Nadja Van Camp, Frédéric Dollé, Bertrand Tavitian

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 12/2008

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Abstract

Neurodegenerative, inflammatory and neoplastic brain disorders involve neuroinflammatory reactions, and a biomarker of neuroinflammation would be useful for diagnostic, drug development and therapy control of these frequent diseases. In vivo imaging can document the expression of the peripheral benzodiazepine receptor (PBR)/translocator protein 18 kDa (TSPO) that is linked to microglial activation and considered a hallmark of neuroinflammation. The prototype positron emission tomography tracer for PBR, [11C]PK11195, has shown limitations that until now have slowed the clinical applications of PBR imaging. In recent years, dozens of new PET and SPECT radioligands for the PBR have been radiolabelled, and several have been evaluated in imaging protocols. Here we review the new PBR ligands proposed as challengers of [11C]PK11195, critically analyze preclinical imaging studies and discuss their potential as neuroinflammation imaging agents.
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Metadata
Title
Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers
Authors
Fabien Chauveau
Hervé Boutin
Nadja Van Camp
Frédéric Dollé
Bertrand Tavitian
Publication date
01-12-2008
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 12/2008
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-008-0908-9

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