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01-05-2010 | Original Article

Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of Shh

Authors: Akio Yamasaki, Chizu Kameda, Rui Xu, Haruo Tanaka, Takehiko Tasaka, Nobuhito Chikazawa, Hiroyuki Suzuki, Takashi Morisaki, Makoto Kubo, Hideya Onishi, Masao Tanaka, Mitsuo Katano

Published in: Cancer Immunology, Immunotherapy | Issue 5/2010

Abstract

Recently, it was reported that Hh signaling is activated in tumor stromal cells but not in tumor cells themselves and that stromal cells may play a role in the proliferation of cancer cells. This suggests the possibility that stromal cells have an important role in the proliferation of tumor cells that may be mediated through Hh signaling. In this report, we present for the first time that inflammation-stimulated monocytes produce Shh through activation of the NF-κB signaling pathway, and that the Shh produced promotes the proliferation of pancreatic cancer cells in a paracrine manner through Hh signaling.

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Title: Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of Shh
Authors: Akio Yamasaki
Chizu Kameda
Rui Xu
Haruo Tanaka
Takehiko Tasaka
Nobuhito Chikazawa
Hiroyuki Suzuki
Takashi Morisaki
Makoto Kubo
Hideya Onishi
Masao Tanaka
Mitsuo Katano
Publication date: 01-05-2010
Publisher: Springer-Verlag
Published in: Cancer Immunology, Immunotherapy / Issue 5/2010
Print ISSN: 0340-7004
Electronic ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-009-0783-7

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