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Breast Cancer Research
Published in: Breast Cancer Research 1/2000

01-12-2001 | Paper Report

Nuclear-cytoplasmic shuttling of p21Cip1/WAF1is regulated by Akt

Author: Karen L Schmeichel

Published in: Breast Cancer Research | Issue 1/2000

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Excerpt

The serine-threonine kinase Akt is a central component of signaling pathways controlling both cellular proliferation and apoptosis. In previous studies the authors showed that overexpression of HER-2/neu, a membrane tyrosine kinase whose upregulation correlates with some breast and ovarian cancers, activates signaling through Akt in NIH3T3 cells. By studying the cellular and molecular consequences of Akt activation in the context of these HER-2/neu overexpressing cells, the authors set out to reveal fundamental information regarding the signaling mechanisms altered during malignant progression. …
Literature
1.
Zhou BP, Liao Y, Xia W, Spohn B, Lee M-H, Hung MC: Cytoplasmic localization of p21Cip1/WAF1by AKT-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol . 2001, 3: 245-252. CrossRefPubMed
Metadata
Title
Nuclear-cytoplasmic shuttling of p21Cip1/WAF1is regulated by Akt
Author
Karen L Schmeichel
Publication date
01-12-2001
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 1/2000
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr-2001-68451

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