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Journal of Cardiothoracic Surgery
Published in: Journal of Cardiothoracic Surgery 1/2024

Open Access 01-12-2024 | NSCLC | Research

The value of lung function assessment and Testin expression detection in clinicopathological features and prognosis of NSCLC patients

Authors: Yanmin Zhang, Gaoming Wang, Qian Zhang, Qian Wang, Jing Luo, Chunhua Ling

Published in: Journal of Cardiothoracic Surgery | Issue 1/2024

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Abstract

Objective

The aim of this study is to investigate the clinical value and potential prognostic significance of lung function assessment and Testin expression in non-small cell lung cancer (NSCLC) patients.

Methods

The NSCLC patients were classified into three groups according to lung function: group of normal lung function, group of PRISm (preserved ratio impaired spirometry) (FEV1, forced expiratory volume during the first second < 80% predicted and FEV1/FVC (forced vital capacity) ≥ 70%) and group of COPD (chronic obstructive pulmonary disease) (FEV1/FVC < 70%). The pre-operational clinicopathological characteristics of these patients were recorded and the markers of systemic inflammatory response, including neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), platelet to lymphocyte ratio (PLR) and eosinophils (EOS), were compared between three groups. The expression of Testin in NSCLC samples was detected by IHC and we further explored the correlation between Testin expression and clinicopathological characteristics and prognosis of NSCLC patients. Finally, Cox regression analysis was conducted to study the prognostic factors of NSCLC patients.

Results

Of the 158 NSCLC patients, percentages of normal lung function, PRISm and COPD were 41.4%, 22.8% and 36.1%, respectively. Patients with tumor in the left lung were more likely to have pulmonary dysfunction (PRISm and COPD) than the right lung. The markers of systemic inflammatory response showed differences to various degree in the three groups and NSCLC patients with PRISm or COPD presented more unfavorable prognosis than patients with normal function. The expression of Testin correlated with lymph node metastasis, TNM stage and tumor invasion of NSCLC patients. Moreover, patients with low Testin expression exhibited poorer disease-free survival and overall survival than those with high Testin expression. In Cox regression analysis, we found that PRISm, COPD and Testin expression served as prognostic factors in NSCLC patients.

Conclusions

The presence of COPD or PRISm influenced systemic inflammatory response and prognosis of NSCLC patients. Testin expression correlated with clinicopathological features and could be potentially used as a prognostic marker in NSCLC.
Literature
1.
Tan WL, et al. Asian Thoracic Oncology Research Group Expert Consensus Statement on Optimal Management of Stage III NSCLC. J Thorac Oncol. 2020;15(3):324–43.CrossRefPubMed
2.
3.
Lim JU, et al. Impact of Combined Chronic Obstructive Pulmonary Disease Status and systemic inflammation on Outcome of Advanced NSCLC: Multicenter Retrospective Cohort Study. Int J Chron Obstruct Pulmon Dis. 2020;15:3323–34.CrossRefPubMedPubMedCentral
4.
Viniol C, Vogelmeier CF. Exacerbations COPD Eur Respir Rev, 2018. 27(147).
5.
Wei X, et al. Imaging Features of Chronic Bronchitis with preserved ratio and impaired spirometry (PRISm). Lung. 2018;196(6):649–58.CrossRefPubMed
6.
Heo IR, et al. Impact of coexistent preserved ratio impaired spirometry on the survival of patients with lung cancer: analysis of data from the Korean Association for Lung Cancer Registry. Thorac Cancer. 2021;12(18):2478–86.CrossRefPubMedPubMedCentral
7.
Caramori G, et al. Molecular links between COPD and lung cancer: new targets for drug discovery? Expert Opin Ther Targets. 2019;23(6):539–53.CrossRefPubMed
8.
Mandaliya H, et al. Prognostic biomarkers in stage IV non-small cell lung cancer (NSCLC): neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), platelet to lymphocyte ratio (PLR) and advanced lung canc er inflammation index (ALI). Transl Lung Cancer Res. 2019;8(6):886–94.CrossRefPubMedPubMedCentral
9.
Russo A, et al. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and outcomes with Nivolumab in Pretreated Non-small Cell Lung Cancer (NSCLC): a large Retrospective Multicenter Study. Adv Ther. 2020;37(3):1145–55.CrossRefPubMed
10.
Sibille A, et al. Clinical benefit to programmed death-1 inhibition for non-small-cell lung cancer is associated with h igher blood eosinophil levels. Acta Oncol. 2020;59(3):257–9.CrossRefPubMed
11.
Osawa H et al. Association between time to treatment failure and peripheral eosinophils in patients with non-small c ell lung cancer treated with immune checkpoint inhibitors. Pol Arch Intern Med, 2021. 131(10).
12.
Gu Z, et al. TESTIN suppresses tumor growth and invasion via manipulating cell cycle progression in endometrial carcinoma. Med Sci Monit. 2014;20:980–7.CrossRefPubMedPubMedCentral
13.
Qiu H, et al. Frequent hypermethylation and loss of heterozygosity of the testis derived transcript gene in ovarian cancer. Cancer Sci. 2010;101(5):1255–60.CrossRefPubMed
14.
15.
Weeks RJ, et al. TESTIN induces Rapid Death and suppresses proliferation in Childhood B Acute Lymphoblastic Leukaemia cells. PLoS ONE. 2016;11(3):e0151341.CrossRefPubMedPubMedCentral
16.
Dong R, et al. TESTIN was commonly hypermethylated and involved in the epithelial-mesenchymal transition of endometrial cancer. APMIS. 2015;123(5):394–400.CrossRefPubMed
17.
Zhong Z, Zhang F, Yin SC. Effects of TESTIN gene expression on proliferation and migration of the 5-8F nasopharyngeal carcinoma cell line. Asian Pac J Cancer Prev. 2015;16(6):2555–9.CrossRefPubMed
18.
Popiel A, Kobierzycki C, Dziegiel P. The role of Testin in Human cancers. Pathol Oncol Res. 2019;25(4):1279–84.CrossRefPubMed
19.
Wang M, et al. Testin is a tumor suppressor in non-small cell lung cancer. Oncol Rep. 2017;37(2):1027–35.CrossRefPubMed
20.
21.
Ceelen JJ, Langen RC, Schols AM. Systemic inflammation in chronic obstructive pulmonary disease and lung cancer: common driver of pulm onary cachexia? Curr Opin Support Palliat Care. 2014;8(4):339–45.CrossRefPubMed
22.
Siemes C, et al. C-reactive protein levels, variation in the C-reactive protein gene, and cancer risk: the Rotterdam S tudy. J Clin Oncol. 2006;24(33):5216–22.CrossRefPubMed
23.
Thomsen M, et al. Inflammatory biomarkers and comorbidities in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012;186(10):982–8.CrossRefPubMed
24.
25.
Wijnant SRA et al. Trajectory and mortality of preserved ratio impaired spirometry: the Rotterdam Study. Eur Respir J, 2020. 55(1).
26.
Heo IR, Kim HC, Kim TH. Health-Related Quality of Life and related factors in persons with preserved ratio impaired spirometr y: data from the Korea National Health and Nutrition Examination Surve. Med (Kaunas), 2020. 57(1).
27.
Pezzuto A, et al. Predictors of respiratory failure after thoracic surgery: a retrospective cohort study with comparison between lobar and sub-lobar resection. J Int Med Res. 2022;50(6):3000605221094531.CrossRefPubMed
28.
Pezzuto A, et al. Short-term benefits of Smoking Cessation improve respiratory function and metabolism in smokers. Int J Chron Obstruct Pulmon Dis. 2023;18:2861–5.CrossRefPubMedPubMedCentral
29.
Jing X, et al. Systemic inflammatory response markers Associated with Infertility and Endometrioma or Uterine Leiomyoma in Endometriosis. Ther Clin Risk Manag. 2020;16:403–12.CrossRefPubMedPubMedCentral
30.
Tataroglu C, et al. Association of macrophages, mast cells and eosinophil leukocytes with angiogenesis and tumor stage in non-small cell lung carcinomas (NSCLC). Lung Cancer. 2004;43(1):47–54.CrossRefPubMed
31.
Lantuejoul S, et al. Telomere maintenance and DNA damage responses during lung carcinogenesis. Clin Cancer Res. 2010;16(11):2979–88.CrossRefPubMed
32.
Caramori G, et al. Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer. Thorax. 2011;66(6):521–7.CrossRefPubMed
33.
McKendry RT, et al. Dysregulation of antiviral function of CD8(+) T cells in the Chronic Obstructive Pulmonary Disease Lu Ng. Role of the PD-1-PD-L1 Axis. Am J Respir Crit Care Med. 2016;193(6):642–51.CrossRefPubMedPubMedCentral
34.
35.
Lin GN, et al. Prognostic impact of circulating monocytes and lymphocyte-to-monocyte ratio on previously untreated m etastatic non-small cell lung cancer patients receiving platinum-based doublet. Med Oncol. 2014;31(7):70.CrossRefPubMed
36.
37.
Osawa H, et al. Absolute increase in the number and proportion of Peripheral eosinophils Associated with Immune checkpoint inhibitor treatment in non-small cell Lung Cancer patients. Cancer Diagn Progn. 2021;1(5):485–90.CrossRefPubMedPubMedCentral
38.
Papanikolaou M, Crump SM, Abbott GW. The focal adhesion protein Testin modulates KCNE2 potassium channel beta subunit activity. Channels (Austin). 2021;15(1):229–38.CrossRefPubMed
39.
Zhu Y, Qiao Q. The relationship between TESTIN expression and the prognosis of colorectal cancer. Pathol Res Pract. 2022;232:153744.CrossRefPubMed
40.
Weeks RJ, et al. Silencing of TESTIN by dense biallelic promoter methylation is the most common molecular event in childhood acute lymphoblastic leukaemia. Mol Cancer. 2010;9:163.CrossRefPubMedPubMedCentral
41.
Sarti M, et al. Differential expression of testin and survivin in breast cancer subtypes. Oncol Rep. 2013;30(2):824–32.CrossRefPubMed
42.
Metadata
Title
The value of lung function assessment and Testin expression detection in clinicopathological features and prognosis of NSCLC patients
Authors
Yanmin Zhang
Gaoming Wang
Qian Zhang
Qian Wang
Jing Luo
Chunhua Ling
Publication date
01-12-2024
Publisher
BioMed Central
Published in
Journal of Cardiothoracic Surgery / Issue 1/2024
Electronic ISSN: 1749-8090
DOI
https://doi.org/10.1186/s13019-024-02720-z

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