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BMC Cancer
Published in: BMC Cancer 1/2019

Open Access 01-12-2019 | NSCLC | Research article

Prognostic value of TGF-β in lung cancer: systematic review and meta-analysis

Authors: Jue Li, Cheng Shen, Xin Wang, Yutian Lai, Kun Zhou, Pengfei Li, Lunxu Liu, Guowei Che

Published in: BMC Cancer | Issue 1/2019

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Abstract

Background

Lung cancer is the most important cause of cancer-related deaths worldwide and the overall survival of patients with non-small cell lung cancer has not improved. Transforming growth factor beta or TGF-β is a polypeptide member of the transforming growth factor beta superfamily of cytokines, while far fewer clinical studies addressing the association between TGF-β expression and the disease prognosis have been reported up to now. Therefore, our meta-analysis aims to determine the prognostic significance of TGF-β expression in lung cancer patients.

Methods

PubMed, EMBASE, the Web of Science and China National Knowledge Infrastructure (CNKI) databases were searched for full-text literature citations. We applied the hazard ratio (HR) with 95% confidence interval (CI) as the appropriate summarized statistics. Q-test and I2 statistic were used to estimate the level of heterogeneity. The publication bias was detected by Begg’s test and Egger’s test.

Results

Eight eligible studies involving 579 patients were selected for this meta-analysis. The combined HR for the eight eligible studies was 2.17 (95% CI: 1.71–2.77, P < 0.00001) and heterogeneity of overall prognosis was relatively low (I2 = 14.2%, P = 0.319). We further undertook the subgroup analysis including assessment of the association between TGF-β expression and pathology of the lung cancer, treatment and quantity of sample in studies. All the results revealed that a significantly high TGF-β expression in patients was an indicator of poor survival. Neither Begg’s test nor Egger’s test found publication bias in any analysis.

Conclusions

The present evidence indicates that TGF-β expression can significantly predict the worse prognosis in patients with lung cancer. The findings of our meta-analysis may be confirmed in the future by the use of more updated review pooling and additional relevant investigations.
Literature
1.
Emprou C. SNAI2 and TWIST1 in lymph node progression in early stages of NSCLC patients. Sci Rep. 2018.
2.
Dvornikov D, Schneider MA, Ohse S, Szczygiel M, Titkova I, Rosenblatt M, Muley T, Warth A, Herth FJ, Dienemann H et al: Expression ratio of the TGF beta-inducible gene MYO10 is prognostic for overall survival of squamous cell lung cancer patients and predicts chemotherapy response. 2018, 8(1):9517.
3.
Deng G, Chen L, Zhang Y, Fan S, Li W, Lu J, Chen X. Fucosyltransferase 2 induced epithelial-mesenchymal transition via TGF-beta/Smad signaling pathway in lung adenocarcinaoma. Exp Cell Res. 2018.
4.
Xie M, He C, Wei S: [Relationship between Expression of TGF-beta1, Smad2, Smad4 and Prognosis of Patients with Resected Non-small Cell Lung Cancer]. Zhong guo fei ai za zhi = Chinese journal of lung cancer 2015, 18(9):543–548.
5.
Zhang S, Che DH, Yang F, Chi CL, Meng HX, Shen J, Qi L, Liu F, Lv LY, Li Y, et al. Tumor-associated macrophages promote tumor metastasis via the TGF-beta/SOX9 axis in non-small cell lung cancer. Oncotarget. 2017;8(59):99801–15.PubMedPubMedCentral
6.
Vazquez PF, Carlini MJ, Daroqui MC, Colombo L, Dalurzo ML, Smith DE, Grasselli J, Pallotta MG, Ehrlich M. Bal de kier Joffe ED et al: TGF-beta specifically enhances the metastatic attributes of murine lung adenocarcinoma: implications for human non-small cell lung cancer. Clinical & experimental metastasis. 2013;30(8):993–1007.CrossRef
7.
Okayama A, Miyagi Y, Oshita F, Ito H, Nakayama H, Nishi M, Kurata Y, Kimura Y, Ryo A, Hirano H. Identification of tyrosine-phosphorylated proteins upregulated during epithelial-mesenchymal transition induced with TGF-beta. J Proteome Res. 2015;14(10):4127–36.PubMedCrossRef
8.
Takanami I, Tanaka F, Hashizume T, Kikuchi K, Yamamoto Y, Yamamoto T, Kodaira S. Transforming growth factor-beta isoforms expressions in pulmonary adenocarcinomas as prognostic markers: an immunohistological study of one hundred and twenty patients. Oncology. 1997;54(2):122–8.PubMedCrossRef
9.
10.
11.
Takanami I, Imamura T, Hashizume T, Kikuchi K, Yamamoto Y, Kodaira S. Transforming growth factor beta 1 as a prognostic factor in pulmonary adenocarcinoma. J Clin Pathol. 1994;47(12):1098–100.PubMedPubMedCentralCrossRef
12.
Kumar S, Guleria R, Mohan A, Singh V, Bharti AC, Das BC. Efficacy of plasma TGF-beta beta 1 level in predicting therapeutic efficacy and prognosis in patients with advanced non-small cell lung Cancer. Cancer Investig. 2011;29(3):202–7.CrossRef
13.
Huang AL, Liu SG, Qi WJ, Zhao YF, Li YM, Lei B, Sheng WJ, Shen H. TGF-beta 1 protein expression in non-small cell lung cancers is correlated with prognosis. Asian Pac J Cancer Prev. 2014;15(19):8143–7.PubMedCrossRef
14.
Gao Y, Wang Y, Sun L, Meng Q, Cai L, Dong X. Expression of TGFbeta-1 and EHD1 correlated with survival of non-small cell lung cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2014;35(9):9371–80.CrossRef
15.
Hasegawa Y, Takanashi S, Kanehira Y, Tsushima T, Imai T, Okumura K. Transforming growth factor-beta1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma. Cancer. 2001;91(5):964–71.PubMedCrossRef
16.
Zhao LJ, Ji W, Zhang L, Ou GF, Feng QF, Zhou ZM, Lei MF, Yang WZ, Wang LH. Changes of circulating transforming growth factor-beta 1 level during radiation therapy are correlated with the prognosis of locally advanced non-small cell lung Cancer. J Thorac Oncol. 2010;5(4):521–5.PubMedCrossRef
17.
Kumar S, Guleria R, Mohan A, Singh V, Ali A, Bharti AC, Das BC. Utility of plasma tumour necrosis factor-alpha and transforming growth factor-beta 1 as predictors of survival and treatment outcome in advanced non-small cell lung carcinoma. Biomarkers. 2010;15(5):446–53.PubMedCrossRef
18.
Liu HL, Zhang MS, Xu SS, Zhang J, Zou J, Yang CC, Zhang Y, Gong C, Kai YZ, Li Y. HOXC8 promotes proliferation and migration through transcriptional upregulation of TGF beta 1 in non-small cell lung cancer. Oncogenesis. 2018;7.
19.
Liu SG, Yuan SH, Wu HY, Liu J, Huang CS. The clinical research of serum VEGF, TGF-beta 1, and Endostatin in non-small cell lung Cancer. Cell Biochem Biophys. 2015;72(1):165–9.PubMedCrossRef
20.
Ye YY, Liu S, Wu CY, Sun ZP. TGF beta modulates inflammatory cytokines and growth factors to create premetastatic microenvironment and stimulate lung metastasis. J Mol Histol. 2015;46(4–5):365–75.PubMedCrossRef
21.
Xiong Y, Zhang J, Shi LZ, Ning YY, Zhu Y, Chen S, Yang M, Chen JY, Zhou GW, Li Q. NOGO-B promotes EMT in lung fibrosis via MMP14 mediates free TGF-beta1 formation. Oncotarget. 2017;8(41):71024–37.PubMedPubMedCentralCrossRef
22.
Yang L, Zhang F, Wang X, Tsai Y, Chuang KH, Keng PC, Lee SO, Chen Y. A FASN-TGF-beta1-FASN regulatory loop contributes to high EMT/metastatic potential of cisplatin-resistant non-small cell lung cancer. Oncotarget. 2016;7(34):55543–54.PubMedPubMedCentral
23.
Yang H, Zhan L, Yang T, Wang L, Li C, Zhao J, Lei Z, Li X, Zhang HT. Ski prevents TGF-beta-induced EMT and cell invasion by repressing SMAD-dependent signaling in non-small cell lung cancer. Oncol Rep. 2015;34(1):87–94.PubMedCrossRef
24.
Khan GJ, Gao Y, Gu M, Wang L, Khan S, Naeem F, Semukunzi H, Roy D, Yuan S, Sun L. TGF-beta1 causes EMT by regulating N-acetyl Glucosaminyl transferases via downregulation of non muscle myosin II-A through JNK/P38/PI3K pathway in lung Cancer. Curr Cancer Drug Targets. 2018;18(2):209–19.PubMedCrossRef
25.
Elmansuri AZ, Tanino MA, Mahabir R, Wang L, Kimura T, Nishihara H, Kinoshita I, Dosaka-Akita H, Tsuda M, Tanaka S. Novel signaling collaboration between TGF-beta and adaptor protein Crk facilitates EMT in human lung cancer. Oncotarget. 2016;7(19):27094–107.PubMedPubMedCentralCrossRef
26.
Xu Y, Lou Z, Lee SH. Arctigenin represses TGF-beta-induced epithelial mesenchymal transition in human lung cancer cells. Biochem Biophys Res Commun. 2017;493(2):934–9.PubMedCrossRef
27.
Wei Y, Li D, Wang D, Qiu T, Liu K. Evaluation of microRNA-203 in bone metastasis of patients with non-small cell lung cancer through TGF-beta/SMAD2 expression. Oncol Rep. 2017.
28.
Wang H, Wu Q, Zhang Y, Zhang HN, Wang YB, Wang W. TGF-beta1-induced epithelial-mesenchymal transition in lung cancer cells involves upregulation of miR-9 and downregulation of its target. E-cadherin Cellular & molecular biology letters. 2017;22:22.CrossRef
Metadata
Title
Prognostic value of TGF-β in lung cancer: systematic review and meta-analysis
Authors
Jue Li
Cheng Shen
Xin Wang
Yutian Lai
Kun Zhou
Pengfei Li
Lunxu Liu
Guowei Che
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2019
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-019-5917-5

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