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Cancer Cell International
Published in: Cancer Cell International 1/2020

Open Access 01-12-2020 | NSCLC | Review

circRNA-miRNA-mRNA regulatory network in human lung cancer: an update

Authors: Zhuo-Zheng Liang, Cheng Guo, Man-Man Zou, Ping Meng, Tian-Tuo Zhang

Published in: Cancer Cell International | Issue 1/2020

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Abstract

Circular RNAs, as hopeful diagnosis markers and therapeutic molecules, have been studied, probed and applied into several diseases, such as cardiovascular diseases, systemic lupus erythematosus, leukemia, pulmonary tuberculosis, and cancer especially. Recently, mounting evidence has supported that circRNAs play a key role in the tumorigenesis, progress, invasion and metastasis in lung cancer. Its special structure—3′–5′ covalent loop—allow it to execute several special functions in both normal eukaryotic cells and cancer cells. Our review summaries the latest studies on characteristics and biogenesis of circRNAs, and highlight the regulatory functions about miRNA sponge of lung-cancer-related circRNAs. In addition, the interaction of the circRNA-miRNA-mRNA regulatory network will also be elaborated in detail in this review. Therefore, this review can provide a new idea or strategy for further development and application in clinical setting in terms of early-diagnosis and better treatment.
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Metadata
Title
circRNA-miRNA-mRNA regulatory network in human lung cancer: an update
Authors
Zhuo-Zheng Liang
Cheng Guo
Man-Man Zou
Ping Meng
Tian-Tuo Zhang
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2020
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-020-01245-4

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Cancer Cell International 1/2020 Go to the issue

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Prognostic role of alternative splicing events in head and neck squamous cell carcinoma

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Downregulation of long non-coding RNA MAFG-AS1 represses tumorigenesis of colorectal cancer cells through the microRNA-149-3p-dependent inhibition of HOXB8

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Long noncoding RNA MIAT promotes non-small cell lung cancer progression by sponging miR-149-5p and regulating FOXM1 expression

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Spider venom components decrease glioblastoma cell migration and invasion through RhoA-ROCK and Na+/K+-ATPase β2: potential molecular entities to treat invasive brain cancer

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Identification of molecular markers associated with the progression and prognosis of endometrial cancer: a bioinformatic study

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CircHIPK3/miR-876-5p/PIK3R1 axis regulates regulation proliferation, migration, invasion, and glutaminolysis in gastric cancer cells
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