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General Thoracic and Cardiovascular Surgery

Published in:

01-09-2019 | NSCLC | Original Article

Chest wall/parietal pleural invasions worsen prognosis in T4 non-small cell lung cancer patients after resection

Authors: Hiroshi Yabuki, Akira Sakurada, Shunsuke Eba, Fumihiko Hoshi, Hisashi Oishi, Yasushi Matsuda, Tetsu Sado, Masafumi Noda, Yoshinori Okada

Published in: General Thoracic and Cardiovascular Surgery | Issue 9/2019

Abstract

Objectives

Appropriate selection for surgery is particularly important in T4 non-small cell lung cancer patients. In clinical settings, patients those who are positive for T4 criteria occasionally are also positive for T3 factors which are independently defined from original T4 or even have multiple T4 factors. Significance of these factors on prognosis is still unknown.

Methods

We retrospectively reviewed clinicopathorogical data of 113 patients with T4 non-small cell lung cancer those who underwent surgery between 1990 and 2015 in Tohoku University Hospital. Significance on prognosis of single or multiple T4 factors and with or without independent T3 factors were statistically analyzed.

Results

No significant difference was seen in the 5-year survival rate between patients with single (35.6%) and multiple (31.4%) T4 factors (P = 0.94), but the rate was significantly lower when patients also had independent T3 factors (19.6%) compared with when they did not (42.5%) (P = 0.011). The 5-year survival rate was particularly lower among patients with invasion of the chest wall or parietal pleura (8.1%) than in those without (40.6%) (P = 0.0052).

Conclusions

Invasion of the chest wall or parietal pleura is poor prognostic factors in T4 non-small cell lung cancer patients.

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Title: Chest wall/parietal pleural invasions worsen prognosis in T4 non-small cell lung cancer patients after resection
Authors: Hiroshi Yabuki
Akira Sakurada
Shunsuke Eba
Fumihiko Hoshi
Hisashi Oishi
Yasushi Matsuda
Tetsu Sado
Masafumi Noda
Yoshinori Okada
Publication date: 01-09-2019
Publisher: Springer Singapore
Keywords: NSCLC
Lung Cancer
Lung Cancer
NSCLC
Lung Cancer
Published in: General Thoracic and Cardiovascular Surgery / Issue 9/2019
Print ISSN: 1863-6705
Electronic ISSN: 1863-6713
DOI: https://doi.org/10.1007/s11748-019-01093-8

At a glance: The STEP trials

Springer Medicine

Chest wall/parietal pleural invasions worsen prognosis in T4 non-small cell lung cancer patients after resection

Abstract

Objectives

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

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