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Journal of Gastrointestinal Surgery
Published in: Journal of Gastrointestinal Surgery 8/2014

01-08-2014 | Invited Commentary

NSAID use and Colorectal Anastomotic Leaks. Caution and Further Investigation

Author: Imran Hassan

Published in: Journal of Gastrointestinal Surgery | Issue 8/2014

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Excerpt

Non-steroidal anti-inflammatory drugs (NSAIDS) are an integral component of the postoperative analgesic regimen, particularly in enhanced recovery protocols for elective colorectal resections. They are administered to reduce opioid requirements and mitigate the side effects of narcotics on the gastrointestinal tract. Recently however, there have been reports in the literature that have raised the possibility of an association between the use of NSAIDS and an increased risk of colorectal anastomotic leaks (AL).1 – 4. …
Literature
1.
Burton TP, Mittal A, Soop M. Nonsteroidal anti-inflammatory drugs and anastomotic dehiscence in bowel surgery: systematic review and meta-analysis of randomized, controlled trials. Dis Colon Rectum. Jan 2013;56(1):126-134.
2.
Gorissen KJ, Benning D, Berghmans T, et al. Risk of anastomotic leakage with non-steroidal anti-inflammatory drugs in colorectal surgery. Br J Surg. May 2012;99(5):721-727.
3.
Holte K, Andersen J, Jakobsen DH, Kehlet H. Cyclo-oxygenase 2 inhibitors and the risk of anastomotic leakage after fast-track colonic surgery. Br J Surg. Jun 2009;96(6):650-654.
4.
Klein M, Gogenur I, Rosenberg J. Postoperative use of non-steroidal anti-inflammatory drugs in patients with anastomotic leakage requiring reoperation after colorectal resection: cohort study based on prospective data. BMJ. 2012;345:e6166.PubMedCentralPubMedCrossRef
5.
Klein M, Krarup PM, Burcharth J, et al. Effect of diclofenac on cyclooxygenase-2 levels and early breaking strength of experimental colonic anastomoses and skin incisions. Eur Surg Res. 2011;46(1):26-31.PubMedCrossRef
Metadata
Title
NSAID use and Colorectal Anastomotic Leaks. Caution and Further Investigation
Author
Imran Hassan
Publication date
01-08-2014
Publisher
Springer US
Published in
Journal of Gastrointestinal Surgery / Issue 8/2014
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-014-2564-7

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