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European Archives of Psychiatry and Clinical Neuroscience

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01-04-2018 | Original Paper

Novelty seeking mediates the effect of DRD3 variation on onset age of amphetamine dependence in Han Chinese population

Authors: Shin-Chang Kuo, Yi-Wei Yeh, Chun-Yen Chen, Chang-Chih Huang, Tien-Yu Chen, Che-Hung Yen, Chih-Sung Liang, Pei-Shen Ho, Ru-Band Lu, San-Yuan Huang

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 3/2018

Abstract

The dopamine receptor D3 (DRD3) gene, one of the candidate genes for amphetamine dependence (AD), is involved in the mesolimbic dopaminergic system, implicated as the underlying mechanism of addiction. Our case–control study aimed to investigate whether the DRD3 gene is associated with the susceptibility to AD and specific personality traits in AD patients. A total of 1060 unrelated Han Chinese subjects (559 AD patients and 501 controls) were screened using the same assessment tool and genotyped for eight DRD3 polymorphisms. All patients met the DSM-IV-TR criteria for AD, and personality traits of 539 were assessed using a Tridimensional Personality Questionnaire. Furthermore, AD individuals were divided into four clinical subgroups based on gender and psychosis status, to reduce the clinical heterogeneity. We found that the ATA haplotype combination for SNPs rs324029, rs6280, and rs9825563, respectively, was significantly associated with total AD patients (p = 0.0003 after 10,000 permutations). Similar results were observed in the both male and non-psychosis subgroup but not in other subgroups. In addition, DRD3 rs9825563 may influence onset age of drug use, partially mediated by novelty seeking in the non-psychosis AD group. In conclusion, DRD3 is a potential genetic factor in the susceptibility to AD and is associated with onset age of drug use through interaction with novelty seeking in a specific patient group in the Han Chinese population.

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Title: Novelty seeking mediates the effect of DRD3 variation on onset age of amphetamine dependence in Han Chinese population
Authors: Shin-Chang Kuo
Yi-Wei Yeh
Chun-Yen Chen
Chang-Chih Huang
Tien-Yu Chen
Che-Hung Yen
Chih-Sung Liang
Pei-Shen Ho
Ru-Band Lu
San-Yuan Huang
Publication date: 01-04-2018
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 3/2018
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-016-0754-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Novelty seeking mediates the effect of DRD3 variation on onset age of amphetamine dependence in Han Chinese population

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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