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01-10-2015 | Gynecologic Oncology

Notch1 ligand signaling pathway activated in cervical cancer: poor prognosis with high-level JAG1/Notch1

Authors: Nasser Ghaly Yousif, Alaa Muhammad Sadiq, Maitham G. Yousif, Rihab H. Al-Mudhafar, Jinan J. Al-Baghdadi, Najah Hadi

Published in: Archives of Gynecology and Obstetrics | Issue 4/2015

Abstract

Objective

Notch signalings are regulated multiple cellular processes during cancer progression. We aimed to investigate the significance and prognostic value of expression of Notch1 and JAG1 in cervical cancer to determine whether they could serve as prognostic predictors.

Methods/materials

The expression of Notch1/JAGD1 was investigated by real-time PCR, western blot assay and its association with overall survival of patients was analyzed by statistical analysis.

Results

Notch1 and JAGD1 expression level were significantly elevated in cervical cancer in comparison to normal specimens and other types of Notch receptors and ligands. It is also proved that Notch1 and JAGD1 expression were to be associated with cervical cancer invasion, lymph node metastasis, and FIGO system. In addition, survival analysis proved that elevated Notch1 and JAGD1 expression were associated with poor overall survival of patients (P = 0.01, P = 0.02 log-rank test), respectively.

Conclusions

The present data proved the over-expression of Notch1/JAGD1 and its association with tumor progression in human cervical cancer, which might be a potential valuable biomarker for cervical cancer and further studies need.

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Title: Notch1 ligand signaling pathway activated in cervical cancer: poor prognosis with high-level JAG1/Notch1
Authors: Nasser Ghaly Yousif
Alaa Muhammad Sadiq
Maitham G. Yousif
Rihab H. Al-Mudhafar
Jinan J. Al-Baghdadi
Najah Hadi
Publication date: 01-10-2015
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 4/2015
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-015-3694-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Notch1 ligand signaling pathway activated in cervical cancer: poor prognosis with high-level JAG1/Notch1

Abstract

Objective

Methods/materials

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods/materials

Results

Conclusions

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