Notch1 hallmarks fibrillary depositions in sporadic Alzheimer’s disease

go back to reference Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991; 82(4):239–59. doi:http://dx.doi.org/10.1007/BF00308809. Accessed 16 July 2014.CrossRefPubMed Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991; 82(4):239–59. doi:http://​dx.​doi.​org/​10.​1007/​BF00308809. Accessed 16 July 2014.CrossRefPubMed

go back to reference Braak H, Braak E, Bohl J, Reintjes R. Age, neurofibrillary changes, A beta-amyloid and the onset of Alzheimer’s disease. Neurosci Lett. 1996; 210(2):87–90. doi:http://dx.doi.org/10.1016/0304-3940(96)12668-9. Accessed 04 Feb 2016.CrossRefPubMed Braak H, Braak E, Bohl J, Reintjes R. Age, neurofibrillary changes, A beta-amyloid and the onset of Alzheimer’s disease. Neurosci Lett. 1996; 210(2):87–90. doi:http://​dx.​doi.​org/​10.​1016/​0304-3940(96)12668-9. Accessed 04 Feb 2016.CrossRefPubMed

go back to reference Braak H, Braak E, Bohl J. Staging of Alzheimer-related cortical destruction. Eur Neurol. 1993; 33(6):403–8.CrossRefPubMed Braak H, Braak E, Bohl J. Staging of Alzheimer-related cortical destruction. Eur Neurol. 1993; 33(6):403–8.CrossRefPubMed

go back to reference De Strooper B, Vassar R, Golde T. The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat Rev Neurol. 2010; 6(2):99–107. doi:http://dx.doi.org/10.1038/nrneurol.2009.218. Accessed 04 Feb 2016.CrossRefPubMedPubMedCentral De Strooper B, Vassar R, Golde T. The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat Rev Neurol. 2010; 6(2):99–107. doi:http://​dx.​doi.​org/​10.​1038/​nrneurol.​2009.​218. Accessed 04 Feb 2016.CrossRefPubMedPubMedCentral

go back to reference Strittmatter WJ, Weisgraber KH, Huang DY, Dong LM, Salvesen GS, Pericak-Vance M, Schmechel D, Saunders AM, Goldgaber D, Roses AD. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc Natl Acad Sci U S A. 1993; 90(17):8098–102. Accessed 04 Feb 2016.CrossRefPubMedPubMedCentral Strittmatter WJ, Weisgraber KH, Huang DY, Dong LM, Salvesen GS, Pericak-Vance M, Schmechel D, Saunders AM, Goldgaber D, Roses AD. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc Natl Acad Sci U S A. 1993; 90(17):8098–102. Accessed 04 Feb 2016.CrossRefPubMedPubMedCentral

go back to reference Abraham R, Moskvina V, Sims R, Hollingworth P, Morgan A, Georgieva L, Dowzell K, Cichon S, Hillmer AM, O’Donovan MC, Williams J, Owen MJ, Kirov G. A genome-wide association study for late-onset Alzheimer’s disease using DNA pooling. BMC Med Genomics. 2008; 1:44. doi:http://dx.doi.org/10.1186/1755-8794-1-44. Accessed 13 Feb 2016.CrossRefPubMedPubMedCentral Abraham R, Moskvina V, Sims R, Hollingworth P, Morgan A, Georgieva L, Dowzell K, Cichon S, Hillmer AM, O’Donovan MC, Williams J, Owen MJ, Kirov G. A genome-wide association study for late-onset Alzheimer’s disease using DNA pooling. BMC Med Genomics. 2008; 1:44. doi:http://​dx.​doi.​org/​10.​1186/​1755-8794-1-44. Accessed 13 Feb 2016.CrossRefPubMedPubMedCentral

go back to reference Beecham GW, Martin ER, Li YJ, Slifer MA, Gilbert JR, Haines JL, Pericak-Vance MA. Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease. Am J Hum Genet. 2009; 84(1):35–43. doi:http://dx.doi.org/10.1016/j.ajhg.2008.12.008. Accessed 13 Feb 2016.CrossRefPubMedPubMedCentral Beecham GW, Martin ER, Li YJ, Slifer MA, Gilbert JR, Haines JL, Pericak-Vance MA. Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease. Am J Hum Genet. 2009; 84(1):35–43. doi:http://​dx.​doi.​org/​10.​1016/​j.​ajhg.​2008.​12.​008. Accessed 13 Feb 2016.CrossRefPubMedPubMedCentral

go back to reference Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere M, Singh Pahwa J, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan A, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown K, Passmore P, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schürmann B, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate A, Kauwe JSK, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn P, van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton A, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Holmans P, O’Donovan M, Owen MJ, Williams J. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer’s disease, and shows evidence for additional susceptibility genes. Nat Genet. 2009; 41(10):1088–93. doi:http://dx.doi.org/10.1038/ng.440. Accessed 13 Feb 2016.CrossRefPubMedPubMedCentral Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere M, Singh Pahwa J, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan A, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown K, Passmore P, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schürmann B, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate A, Kauwe JSK, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn P, van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton A, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Holmans P, O’Donovan M, Owen MJ, Williams J. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer’s disease, and shows evidence for additional susceptibility genes. Nat Genet. 2009; 41(10):1088–93. doi:http://​dx.​doi.​org/​10.​1038/​ng.​440. Accessed 13 Feb 2016.CrossRefPubMedPubMedCentral

go back to reference Hall AM, Roberson ED. Mouse models of Alzheimer’s disease. Brain Res Bull. 2012; 88(1):3–12. doi:http://dx.doi.org/10.1016/j.brainresbull.2011.11.017. Accessed 13 Feb 2016.CrossRefPubMed Hall AM, Roberson ED. Mouse models of Alzheimer’s disease. Brain Res Bull. 2012; 88(1):3–12. doi:http://​dx.​doi.​org/​10.​1016/​j.​brainresbull.​2011.​11.​017. Accessed 13 Feb 2016.CrossRefPubMed

go back to reference Saito T, Matsuba Y, Mihira N, Takano J, Nilsson P, Itohara S, Iwata N, Saido TC. Single App knock-in mouse models of Alzheimer’s disease. Nat Neurosci. 2014; 17(5):661–3. doi:http://dx.doi.org/10.1038/nn.3697. Accessed 26 July 2015.CrossRefPubMed Saito T, Matsuba Y, Mihira N, Takano J, Nilsson P, Itohara S, Iwata N, Saido TC. Single App knock-in mouse models of Alzheimer’s disease. Nat Neurosci. 2014; 17(5):661–3. doi:http://​dx.​doi.​org/​10.​1038/​nn.​3697. Accessed 26 July 2015.CrossRefPubMed

go back to reference Krstic D, Madhusudan A, Doehner J, Vogel P, Notter T, Imhof C, Manalastas A, Hilfiker M, Pfister S, Schwerdel C, Riether C, Meyer U, Knuesel I. Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice. J Neuroinflammation. 2012; 9(1):151. doi:http://dx.doi.org/10.1186/1742-2094-9-151. Accessed 25 July 2013.CrossRefPubMedPubMedCentral Krstic D, Madhusudan A, Doehner J, Vogel P, Notter T, Imhof C, Manalastas A, Hilfiker M, Pfister S, Schwerdel C, Riether C, Meyer U, Knuesel I. Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice. J Neuroinflammation. 2012; 9(1):151. doi:http://​dx.​doi.​org/​10.​1186/​1742-2094-9-151. Accessed 25 July 2013.CrossRefPubMedPubMedCentral

go back to reference Sheng JG, Bora SH, Xu G, Borchelt DR, Price DL, Koliatsos VE. Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice. Neurobiol Dis. 2003; 14(1):133–45. doi:http://dx.doi.org/10.1016/S0969-9961(03)00069-X. Accessed 04 Feb 2016.CrossRefPubMed Sheng JG, Bora SH, Xu G, Borchelt DR, Price DL, Koliatsos VE. Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice. Neurobiol Dis. 2003; 14(1):133–45. doi:http://​dx.​doi.​org/​10.​1016/​S0969-9961(03)00069-X. Accessed 04 Feb 2016.CrossRefPubMed

go back to reference Woo HN, Park JS, Gwon AR, Arumugam TV, Jo DG. Alzheimer’s disease and Notch signaling. Biochem Biophys Res Commun. 2009; 390(4):1093–7.CrossRefPubMed Woo HN, Park JS, Gwon AR, Arumugam TV, Jo DG. Alzheimer’s disease and Notch signaling. Biochem Biophys Res Commun. 2009; 390(4):1093–7.CrossRefPubMed

go back to reference Schroeter EH, Kisslinger JA, Kopan R. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature. 1998; 393(6683):382–6.CrossRefPubMed Schroeter EH, Kisslinger JA, Kopan R. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature. 1998; 393(6683):382–6.CrossRefPubMed

go back to reference Brou C, Logeat F, Gupta N, Bessia C, LeBail O, Doedens JR, Cumano A, Roux P, Black RA, Israel A. A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol Cell. 2000; 5(2):207–16.CrossRefPubMed Brou C, Logeat F, Gupta N, Bessia C, LeBail O, Doedens JR, Cumano A, Roux P, Black RA, Israel A. A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol Cell. 2000; 5(2):207–16.CrossRefPubMed

go back to reference De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 1999; 398(6727):518–22.CrossRefPubMed De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 1999; 398(6727):518–22.CrossRefPubMed

go back to reference Kopan R, Ilagan MXG. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell. 2009; 137(2):216–33. doi:http://dx.doi.org/10.1016/j.cell.2009.03.045. Accessed 15 Dec 2015.CrossRefPubMedPubMedCentral Kopan R, Ilagan MXG. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell. 2009; 137(2):216–33. doi:http://​dx.​doi.​org/​10.​1016/​j.​cell.​2009.​03.​045. Accessed 15 Dec 2015.CrossRefPubMedPubMedCentral

go back to reference Song JK, Giniger E. Noncanonical notch function in motor axon guidance is mediated by Rac GTPase and the GEF1 domain of trio. Dev Dyn. 2011; 240(2):324–2.CrossRefPubMedPubMedCentral Song JK, Giniger E. Noncanonical notch function in motor axon guidance is mediated by Rac GTPase and the GEF1 domain of trio. Dev Dyn. 2011; 240(2):324–2.CrossRefPubMedPubMedCentral

go back to reference Guruharsha KG, Kankel MW, Artavanis-Tsakonas S. The Notch signalling system: recent insights into the complexity of a conserved pathway. Nat Rev Genet. 2012; 13(9):654–66. doi:http://dx.doi.org/10.1038/nrg3272. Accessed 11 Nov 2013.CrossRefPubMedPubMedCentral Guruharsha KG, Kankel MW, Artavanis-Tsakonas S. The Notch signalling system: recent insights into the complexity of a conserved pathway. Nat Rev Genet. 2012; 13(9):654–66. doi:http://​dx.​doi.​org/​10.​1038/​nrg3272. Accessed 11 Nov 2013.CrossRefPubMedPubMedCentral

go back to reference Alberi L, Hoey SE, Brai E, Scotti AL, Marathe S. Notch signaling in the brain: in good and bad times. Ageing Res Rev. 2013; 12(3):801–14. doi:http://dx.doi.org/10.1016/j.arr.2013.03.004. Accessed 01 Sept 2014.CrossRefPubMed Alberi L, Hoey SE, Brai E, Scotti AL, Marathe S. Notch signaling in the brain: in good and bad times. Ageing Res Rev. 2013; 12(3):801–14. doi:http://​dx.​doi.​org/​10.​1016/​j.​arr.​2013.​03.​004. Accessed 01 Sept 2014.CrossRefPubMed

go back to reference Stump G, Durrer A, Klein AL, Lutolf S, Suter U, Taylor V. Notch1 and its ligands Delta-like and Jagged are expressed and active in distinct cell populations in the postnatal mouse brain. Mech Dev. 2002; 114(1-2):153–9.CrossRefPubMed Stump G, Durrer A, Klein AL, Lutolf S, Suter U, Taylor V. Notch1 and its ligands Delta-like and Jagged are expressed and active in distinct cell populations in the postnatal mouse brain. Mech Dev. 2002; 114(1-2):153–9.CrossRefPubMed

go back to reference Alberi L, Liu S, Wang Y, Badie R, Smith-Hicks C, Wu J, Pierfelice TJ, Abazyan B, Mattson MP, Kuhl D, Pletnikov M, Worley PF, Gaiano N. Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks. Neuron. 2011; 69(3):437–4.CrossRefPubMedPubMedCentral Alberi L, Liu S, Wang Y, Badie R, Smith-Hicks C, Wu J, Pierfelice TJ, Abazyan B, Mattson MP, Kuhl D, Pletnikov M, Worley PF, Gaiano N. Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks. Neuron. 2011; 69(3):437–4.CrossRefPubMedPubMedCentral

go back to reference Wang Y, Chan SL, Miele L, Yao PJ, Mackes J, Ingram DK, Mattson MP, Furukawa K. Involvement of Notch signaling in hippocampal synaptic plasticity. Proc Natl Acad Sci U S A. 2004; 101(25):9458–62.CrossRefPubMedPubMedCentral Wang Y, Chan SL, Miele L, Yao PJ, Mackes J, Ingram DK, Mattson MP, Furukawa K. Involvement of Notch signaling in hippocampal synaptic plasticity. Proc Natl Acad Sci U S A. 2004; 101(25):9458–62.CrossRefPubMedPubMedCentral

go back to reference Costa RM, Honjo T, Silva AJ. Learning and memory deficits in Notch mutant mice. Curr Biol. 2003; 13(15):1348–54.CrossRefPubMed Costa RM, Honjo T, Silva AJ. Learning and memory deficits in Notch mutant mice. Curr Biol. 2003; 13(15):1348–54.CrossRefPubMed

go back to reference Brai E, Marathe S, Zentilin L, Giacca M, Nimpf J, Kretz R, Scotti A, Alberi L. Notch1 activity in the olfactory bulb is odour-dependent and contributes to olfactory behaviour. Eur J Neurosci. 2014; 40(10):3436–449. doi:http://dx.doi.org/10.1111/ejn.12719. Accessed 06 Jan 2015.CrossRefPubMed Brai E, Marathe S, Zentilin L, Giacca M, Nimpf J, Kretz R, Scotti A, Alberi L. Notch1 activity in the olfactory bulb is odour-dependent and contributes to olfactory behaviour. Eur J Neurosci. 2014; 40(10):3436–449. doi:http://​dx.​doi.​org/​10.​1111/​ejn.​12719. Accessed 06 Jan 2015.CrossRefPubMed

go back to reference Kovács T. Mechanisms of olfactory dysfunction in aging and neurodegenerative disorders. Ageing Res Rev. 2004; 3(2):215–32. doi:http://dx.doi.org/10.1016/j.arr.2003.10.003. Accessed 14 Oct 2013.CrossRefPubMed Kovács T. Mechanisms of olfactory dysfunction in aging and neurodegenerative disorders. Ageing Res Rev. 2004; 3(2):215–32. doi:http://​dx.​doi.​org/​10.​1016/​j.​arr.​2003.​10.​003. Accessed 14 Oct 2013.CrossRefPubMed

go back to reference Daulatzai MA. Quintessential risk factors: their role in promoting cognitive dysfunction and Alzheimer’s disease. Neurochem Res. 2012; 37(12):2627–58. doi:http://dx.doi.org/10.1007/s11064-012-0854-6. Accessed 23 June 2013.CrossRefPubMed Daulatzai MA. Quintessential risk factors: their role in promoting cognitive dysfunction and Alzheimer’s disease. Neurochem Res. 2012; 37(12):2627–58. doi:http://​dx.​doi.​org/​10.​1007/​s11064-012-0854-6. Accessed 23 June 2013.CrossRefPubMed

go back to reference Arumugam TV, Chan SL, Jo DG, Yilmaz G, Tang SC, Cheng A, Gleichmann M, Okun E, Dixit VD, Chigurupati S, Mughal MR, Ouyang X, Miele L, Magnus T, Poosala S, Granger DN, Mattson MP. Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nat Med. 2006; 12(6):621–3.CrossRefPubMed Arumugam TV, Chan SL, Jo DG, Yilmaz G, Tang SC, Cheng A, Gleichmann M, Okun E, Dixit VD, Chigurupati S, Mughal MR, Ouyang X, Miele L, Magnus T, Poosala S, Granger DN, Mattson MP. Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nat Med. 2006; 12(6):621–3.CrossRefPubMed

go back to reference Alberi L, Chi Z, Kadam SD, Mulholland JD, Dawson VL, Gaiano N, Comi AM. Neonatal stroke in mice causes long-term changes in neuronal Notch-2 expression that may contribute to prolonged injury. Stroke. 2010; 41(10 Suppl):64–71.CrossRef Alberi L, Chi Z, Kadam SD, Mulholland JD, Dawson VL, Gaiano N, Comi AM. Neonatal stroke in mice causes long-term changes in neuronal Notch-2 expression that may contribute to prolonged injury. Stroke. 2010; 41(10 Suppl):64–71.CrossRef

go back to reference Marathe S, Liu S, Brai E, Kaczarowski M, Alberi L. Notch signaling in response to excitotoxicity induces neurodegeneration via erroneous cell cycle reentry. Cell Death Differ. 2015. doi:http://dx.doi.org/10.1038/cdd.2015.23. Accessed 27 Mar 2015. Marathe S, Liu S, Brai E, Kaczarowski M, Alberi L. Notch signaling in response to excitotoxicity induces neurodegeneration via erroneous cell cycle reentry. Cell Death Differ. 2015. doi:http://​dx.​doi.​org/​10.​1038/​cdd.​2015.​23. Accessed 27 Mar 2015.

go back to reference Wei Z, Chigurupati S, Arumugam TV, Jo DG, Li H, Chan SL. Notch activation enhances the microglia-mediated inflammatory response associated with focal cerebral ischemia. Stroke. 2011; 42(9):2589–94.CrossRefPubMed Wei Z, Chigurupati S, Arumugam TV, Jo DG, Li H, Chan SL. Notch activation enhances the microglia-mediated inflammatory response associated with focal cerebral ischemia. Stroke. 2011; 42(9):2589–94.CrossRefPubMed

go back to reference Berezovska O, Xia MQ, Hyman BT. Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease. J Neuropathol Exp Neurol. 1998; 57(8):738–45.CrossRefPubMed Berezovska O, Xia MQ, Hyman BT. Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease. J Neuropathol Exp Neurol. 1998; 57(8):738–45.CrossRefPubMed

go back to reference Moehlmann T, Winkler E, Xia X, Edbauer D, Murrell J, Capell A, Kaether C, Zheng H, Ghetti B, Haass C, Steiner H. Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production. Proc Natl Acad Sci U S A. 2002; 99(12):8025–30.CrossRefPubMed Moehlmann T, Winkler E, Xia X, Edbauer D, Murrell J, Capell A, Kaether C, Zheng H, Ghetti B, Haass C, Steiner H. Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production. Proc Natl Acad Sci U S A. 2002; 99(12):8025–30.CrossRefPubMed

go back to reference Fischer DF, van Dijk R, Sluijs JA, Nair SM, Racchi M, Levelt CN, van Leeuwen FW, Hol EM. Activation of the Notch pathway in Down syndrome: cross-talk of Notch and APP. Faseb J. 2005; 19(11):1451–8.CrossRefPubMed Fischer DF, van Dijk R, Sluijs JA, Nair SM, Racchi M, Levelt CN, van Leeuwen FW, Hol EM. Activation of the Notch pathway in Down syndrome: cross-talk of Notch and APP. Faseb J. 2005; 19(11):1451–8.CrossRefPubMed

go back to reference Okochi M, Steiner H, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Takeda M, Haass C. Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. EMBO J. 2002; 21(20):5408–16. doi:http://dx.doi.org/10.1093/emboj/cdf541. Accessed 12 Mar 2015.CrossRefPubMedPubMedCentral Okochi M, Steiner H, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Takeda M, Haass C. Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. EMBO J. 2002; 21(20):5408–16. doi:http://​dx.​doi.​org/​10.​1093/​emboj/​cdf541. Accessed 12 Mar 2015.CrossRefPubMedPubMedCentral

go back to reference Strooper BD. Lessons from a failed γ-Secretase Alzheimer trial. Cell. 2014; 159(4):721–6. doi:http://dx.doi.org/10.1016/j.cell.2014.10.016. Accessed 04 Feb 2016.CrossRefPubMed Strooper BD. Lessons from a failed γ-Secretase Alzheimer trial. Cell. 2014; 159(4):721–6. doi:http://​dx.​doi.​org/​10.​1016/​j.​cell.​2014.​10.​016. Accessed 04 Feb 2016.CrossRefPubMed

go back to reference García-Ayllón MS, Campanari ML, Brinkmalm G, Rábano A, Alom J, Saura CA, Andreasen N, Blennow K, Sáez-Valero J. CSF Presenilin-1 complexes are increased in Alzheimer’s disease. Acta Neuropathol Commun. 2013; 1:46. doi:http://dx.doi.org/10.1186/2051-5960-1-46. Accessed 04 Feb 2016.CrossRefPubMedPubMedCentral García-Ayllón MS, Campanari ML, Brinkmalm G, Rábano A, Alom J, Saura CA, Andreasen N, Blennow K, Sáez-Valero J. CSF Presenilin-1 complexes are increased in Alzheimer’s disease. Acta Neuropathol Commun. 2013; 1:46. doi:http://​dx.​doi.​org/​10.​1186/​2051-5960-1-46. Accessed 04 Feb 2016.CrossRefPubMedPubMedCentral

go back to reference Grandbarbe L, Michelucci A, Heurtaux T, Hemmer K, Morga E, Heuschling P. Notch signaling modulates the activation of microglial cells. Glia. 2007; 55(15):1519–30. doi:http://dx.doi.org/10.1002/glia.20553. Accessed 08 Dec 2015.CrossRefPubMed Grandbarbe L, Michelucci A, Heurtaux T, Hemmer K, Morga E, Heuschling P. Notch signaling modulates the activation of microglial cells. Glia. 2007; 55(15):1519–30. doi:http://​dx.​doi.​org/​10.​1002/​glia.​20553. Accessed 08 Dec 2015.CrossRefPubMed

go back to reference Perry G, Rizzuto N, Autilio-Gambetti L, Gambetti P. Paired helical filaments from Alzheimer disease patients contain cytoskeletal components. Proc Natl Acad Sci U S A. 1985; 82(11):3916–20. Accessed 10 Dec 2015.CrossRefPubMedPubMedCentral Perry G, Rizzuto N, Autilio-Gambetti L, Gambetti P. Paired helical filaments from Alzheimer disease patients contain cytoskeletal components. Proc Natl Acad Sci U S A. 1985; 82(11):3916–20. Accessed 10 Dec 2015.CrossRefPubMedPubMedCentral

go back to reference Schutzer SE, Liu T, Natelson BH, Angel TE, Schepmoes AA, Purvine SO, Hixson KK, Lipton MS, Camp DGII, Coyle PK, Smith RD, Bergquist J. Establishing the proteome of normal human cerebrospinal fluid. PLoS ONE. 2010; 5(6):10980. doi:http://dx.doi.org/10.1371/journal.pone.0010980. Accessed 03 Nov 2015.CrossRef Schutzer SE, Liu T, Natelson BH, Angel TE, Schepmoes AA, Purvine SO, Hixson KK, Lipton MS, Camp DGII, Coyle PK, Smith RD, Bergquist J. Establishing the proteome of normal human cerebrospinal fluid. PLoS ONE. 2010; 5(6):10980. doi:http://​dx.​doi.​org/​10.​1371/​journal.​pone.​0010980. Accessed 03 Nov 2015.CrossRef

go back to reference Dries DR, Yu G, Herz J. Extracting β-amyloid from Alzheimer’s disease. PNAS. 2012; 109(9):3199–200. doi:http://dx.doi.org/10.1073/pnas.1121560109. Accessed 10 Feb 2015.CrossRefPubMedPubMedCentral Dries DR, Yu G, Herz J. Extracting β-amyloid from Alzheimer’s disease. PNAS. 2012; 109(9):3199–200. doi:http://​dx.​doi.​org/​10.​1073/​pnas.​1121560109. Accessed 10 Feb 2015.CrossRefPubMedPubMedCentral

go back to reference Liu L, Drouet V, Wu JW, Witter MP, Small SA, Clelland C, Duff K. Trans-synaptic spread of tau pathology in vivo. PLoS ONE. 2012; 7(2):31302. doi:http://dx.doi.org/10.1371/journal.pone.0031302. Accessed 30 Jan 2016.CrossRef Liu L, Drouet V, Wu JW, Witter MP, Small SA, Clelland C, Duff K. Trans-synaptic spread of tau pathology in vivo. PLoS ONE. 2012; 7(2):31302. doi:http://​dx.​doi.​org/​10.​1371/​journal.​pone.​0031302. Accessed 30 Jan 2016.CrossRef

go back to reference Crowner D, Le Gall M, Gates MA, Giniger E. Notch steers Drosophila ISNb motor axons by regulating the Abl signaling pathway. Curr Biol. 2003; 13(11):967–72.CrossRefPubMed Crowner D, Le Gall M, Gates MA, Giniger E. Notch steers Drosophila ISNb motor axons by regulating the Abl signaling pathway. Curr Biol. 2003; 13(11):967–72.CrossRefPubMed

go back to reference Ferrari-Toninelli G, Bonini SA, Bettinsoli P, Uberti D, Memo M. Microtubule stabilizing effect of notch activation in primary cortical neurons. Neuroscience. 2008; 154(3):946–52.CrossRefPubMed Ferrari-Toninelli G, Bonini SA, Bettinsoli P, Uberti D, Memo M. Microtubule stabilizing effect of notch activation in primary cortical neurons. Neuroscience. 2008; 154(3):946–52.CrossRefPubMed

go back to reference Redmond L, Oh SR, Hicks C, Weinmaster G, Ghosh A. Nuclear Notch1 signaling and the regulation of dendritic development. Nat Neurosci. 2000; 3(1):30–40.CrossRefPubMed Redmond L, Oh SR, Hicks C, Weinmaster G, Ghosh A. Nuclear Notch1 signaling and the regulation of dendritic development. Nat Neurosci. 2000; 3(1):30–40.CrossRefPubMed

go back to reference Sestan N, Artavanis-Tsakonas S, Rakic P. Contact-dependent inhibition of cortical neurite growth mediated by notch signaling. Science. 1999; 286(5440):741–6.CrossRefPubMed Sestan N, Artavanis-Tsakonas S, Rakic P. Contact-dependent inhibition of cortical neurite growth mediated by notch signaling. Science. 1999; 286(5440):741–6.CrossRefPubMed

go back to reference Liou YC, Sun A, Ryo A, Zhou XZ, Yu ZX, Huang HK, Uchida T, Bronson R, Bing G, Li X, Hunter T, Lu KP. Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature. 2003; 424(6948):556–61. doi:http://dx.doi.org/10.1038/nature01832. Accessed 04 May 2015.CrossRefPubMed Liou YC, Sun A, Ryo A, Zhou XZ, Yu ZX, Huang HK, Uchida T, Bronson R, Bing G, Li X, Hunter T, Lu KP. Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature. 2003; 424(6948):556–61. doi:http://​dx.​doi.​org/​10.​1038/​nature01832. Accessed 04 May 2015.CrossRefPubMed

go back to reference Blair LJ, Baker JD, Sabbagh JJ, Dickey CA. The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer’s disease. J Neurochem. 2015; 133(1):1–13. doi:http://dx.doi.org/10.1111/jnc.13033. Accessed 05 May 2015.CrossRefPubMedPubMedCentral Blair LJ, Baker JD, Sabbagh JJ, Dickey CA. The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer’s disease. J Neurochem. 2015; 133(1):1–13. doi:http://​dx.​doi.​org/​10.​1111/​jnc.​13033. Accessed 05 May 2015.CrossRefPubMedPubMedCentral

go back to reference Rustighi A, Tiberi L, Soldano A, Napoli M, Nuciforo P, Rosato A, Kaplan F, Capobianco A, Pece S, Di Fiore PP, Del Sal G. The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer. Nat Cell Biol. 2009; 11(2):133–42.CrossRefPubMed Rustighi A, Tiberi L, Soldano A, Napoli M, Nuciforo P, Rosato A, Kaplan F, Capobianco A, Pece S, Di Fiore PP, Del Sal G. The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer. Nat Cell Biol. 2009; 11(2):133–42.CrossRefPubMed

go back to reference Rustighi A, Zannini A, Tiberi L, Sommaggio R, Piazza S, Sorrentino G, Nuzzo S, Tuscano A, Eterno V, Benvenuti F, Santarpia L, Aifantis I, Rosato A, Bicciato S, Zambelli A, Del Sal G. Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast. EMBO Mol Med. 2014; 6(1):99–119. doi:http://dx.doi.org/10.1002/emmm.201302909. Accessed 04 Feb 2016.CrossRefPubMed Rustighi A, Zannini A, Tiberi L, Sommaggio R, Piazza S, Sorrentino G, Nuzzo S, Tuscano A, Eterno V, Benvenuti F, Santarpia L, Aifantis I, Rosato A, Bicciato S, Zambelli A, Del Sal G. Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast. EMBO Mol Med. 2014; 6(1):99–119. doi:http://​dx.​doi.​org/​10.​1002/​emmm.​201302909. Accessed 04 Feb 2016.CrossRefPubMed

go back to reference Marathe S, Alberi L. Notch in memories: points to remember. Hippocampus. 2015; 25(7):771–8. doi:http://dx.doi.org/10.1002/hipo.22412. Accessed 09 Nov 2015.CrossRefPubMed Marathe S, Alberi L. Notch in memories: points to remember. Hippocampus. 2015; 25(7):771–8. doi:http://​dx.​doi.​org/​10.​1002/​hipo.​22412. Accessed 09 Nov 2015.CrossRefPubMed

go back to reference Brai E, Marathe S, Astori S, Fredj NB, Perry E, Lamy C, Scotti A, Alberi L. Notch1 regulates hippocampal plasticity through interaction with the reelin pathway, glutamatergic transmission and CREB signaling. Front Cell Neurosci. 2015; 9. doi:http://dx.doi.org/10.3389/fncel.2015.00447. Accessed 05 Feb 2016. Brai E, Marathe S, Astori S, Fredj NB, Perry E, Lamy C, Scotti A, Alberi L. Notch1 regulates hippocampal plasticity through interaction with the reelin pathway, glutamatergic transmission and CREB signaling. Front Cell Neurosci. 2015; 9. doi:http://​dx.​doi.​org/​10.​3389/​fncel.​2015.​00447. Accessed 05 Feb 2016.

go back to reference Doehner J, Genoud C, Imhof C, Krstic D, Knuesel I. Extrusion of misfolded and aggregated proteins – a protective strategy of aging neurons?Eur J NeuroSci. 2012; 35(12):1938–50. doi:http://dx.doi.org/10.1111/j.1460-9568.2012.08154.x. Accessed 13 Feb 2016.CrossRefPubMed Doehner J, Genoud C, Imhof C, Krstic D, Knuesel I. Extrusion of misfolded and aggregated proteins – a protective strategy of aging neurons?Eur J NeuroSci. 2012; 35(12):1938–50. doi:http://​dx.​doi.​org/​10.​1111/​j.​1460-9568.​2012.​08154.​x. Accessed 13 Feb 2016.CrossRefPubMed

go back to reference Xiang Y, Bu XL, Liu YH, Zhu C, Shen LL, Jiao SS, Zhu XY, Giunta B, Tan J, Song WH, Zhou HD, Zhou XF, Wang YJ. Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer’s disease. Acta Neuropathol. 2015; 130(4):487–99. doi:http://dx.doi.org/10.1007/s00401-015-1477-1. Accessed 13 Feb 2016.CrossRefPubMedPubMedCentral Xiang Y, Bu XL, Liu YH, Zhu C, Shen LL, Jiao SS, Zhu XY, Giunta B, Tan J, Song WH, Zhou HD, Zhou XF, Wang YJ. Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer’s disease. Acta Neuropathol. 2015; 130(4):487–99. doi:http://​dx.​doi.​org/​10.​1007/​s00401-015-1477-1. Accessed 13 Feb 2016.CrossRefPubMedPubMedCentral

go back to reference Morga E, Mouad-Amazzal L, Felten P, Heurtaux T, Moro M, Michelucci A, Gabel S, Grandbarbe L, Heuschling P. Jagged1 regulates the activation of astrocytes via modulation of NFkappaB and JAK/STAT/SOCS pathways. Glia. 2009; 57(16):1741–53.CrossRefPubMed Morga E, Mouad-Amazzal L, Felten P, Heurtaux T, Moro M, Michelucci A, Gabel S, Grandbarbe L, Heuschling P. Jagged1 regulates the activation of astrocytes via modulation of NFkappaB and JAK/STAT/SOCS pathways. Glia. 2009; 57(16):1741–53.CrossRefPubMed

go back to reference Cao Q, Lu J, Kaur C, Sivakumar V, Li F, Cheah PS, Dheen ST, Ling EA. Expression of Notch-1 receptor and its ligands Jagged-1 and Delta-1 in amoeboid microglia in postnatal rat brain and murine BV-2 cells. Glia. 2008; 56(11):1224–37.CrossRefPubMed Cao Q, Lu J, Kaur C, Sivakumar V, Li F, Cheah PS, Dheen ST, Ling EA. Expression of Notch-1 receptor and its ligands Jagged-1 and Delta-1 in amoeboid microglia in postnatal rat brain and murine BV-2 cells. Glia. 2008; 56(11):1224–37.CrossRefPubMed

go back to reference Sunderland T, Linker G, Mirza N, et al. DEcreased beta-amyloid1-42 and increased tau levels in cerebrospinal fluid of patients with alzheimer disease. JAMA. 2003; 289(16):2094–103. doi:http://dx.doi.org/10.1001/jama.289.16.2094. Accessed 08 Oct 2015.CrossRefPubMed Sunderland T, Linker G, Mirza N, et al. DEcreased beta-amyloid1-42 and increased tau levels in cerebrospinal fluid of patients with alzheimer disease. JAMA. 2003; 289(16):2094–103. doi:http://​dx.​doi.​org/​10.​1001/​jama.​289.​16.​2094. Accessed 08 Oct 2015.CrossRefPubMed

go back to reference Lopez-Font I, Cuchillo-Ibañez I, Sogorb-Esteve A, García-Ayllón MS, Sáez-Valero J. Transmembrane amyloid-related proteins in CSF as potential biomarkers for Alzheimer’s disease. Front Neurol. 2015; 125. doi:http://dx.doi.org/10.3389/fneur.2015.00125. Accessed 04 Feb 2016. Lopez-Font I, Cuchillo-Ibañez I, Sogorb-Esteve A, García-Ayllón MS, Sáez-Valero J. Transmembrane amyloid-related proteins in CSF as potential biomarkers for Alzheimer’s disease. Front Neurol. 2015; 125. doi:http://​dx.​doi.​org/​10.​3389/​fneur.​2015.​00125. Accessed 04 Feb 2016.

go back to reference Sixt SU, Dahlmann B. Extracellular, circulating proteasomes and ubiquitin – Incidence and relevance. Biochimica et Biophysica Acta (BBA) - Mol Basis Disease. 2008; 1782(12):817–23. doi:http://dx.doi.org/10.1016/j.bbadis.2008.06.005. Accessed 13 Feb 2016.CrossRef Sixt SU, Dahlmann B. Extracellular, circulating proteasomes and ubiquitin – Incidence and relevance. Biochimica et Biophysica Acta (BBA) - Mol Basis Disease. 2008; 1782(12):817–23. doi:http://​dx.​doi.​org/​10.​1016/​j.​bbadis.​2008.​06.​005. Accessed 13 Feb 2016.CrossRef

go back to reference Mueller O, Anlasik T, Wiedemann J, Thomassen J, Wohlschlaeger J, Hagel V, Keyvani K, Schwieger I, Dahlmann B, Sure U, Sixt SU. Circulating extracellular proteasome in the cerebrospinal fluid: a study on concentration and proteolytic activity. J Mol Neurosci. 2011; 46(3):509–15. doi:http://dx.doi.org/10.1007/s12031-011-9631-2. Accessed 13 Feb 2016.CrossRef Mueller O, Anlasik T, Wiedemann J, Thomassen J, Wohlschlaeger J, Hagel V, Keyvani K, Schwieger I, Dahlmann B, Sure U, Sixt SU. Circulating extracellular proteasome in the cerebrospinal fluid: a study on concentration and proteolytic activity. J Mol Neurosci. 2011; 46(3):509–15. doi:http://​dx.​doi.​org/​10.​1007/​s12031-011-9631-2. Accessed 13 Feb 2016.CrossRef

go back to reference Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M. Secretion of the Notch-1 Abeta-like peptide during Notch signaling. J Biol Chem. 2006; 281(12):7890–8.CrossRefPubMed Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M. Secretion of the Notch-1 Abeta-like peptide during Notch signaling. J Biol Chem. 2006; 281(12):7890–8.CrossRefPubMed

go back to reference Deane R, Bell R, Sagare A, Zlokovic B. Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer’s disease. CNS Neurol Disord Drug Targets. 2009; 8(1):16–30. Accessed 13 Feb 2016.CrossRefPubMedPubMedCentral Deane R, Bell R, Sagare A, Zlokovic B. Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer’s disease. CNS Neurol Disord Drug Targets. 2009; 8(1):16–30. Accessed 13 Feb 2016.CrossRefPubMedPubMedCentral

go back to reference Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Perlmutter D, Coma M, Zhong Z, Zlokovic BV. Clearance of amyloid-beta by circulating lipoprotein receptors. Nat Med. 2007; 13(9):1029–31. doi:http://dx.doi.org/10.1038/nm1635. Accessed 13 Feb 2016.CrossRefPubMedPubMedCentral Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Perlmutter D, Coma M, Zhong Z, Zlokovic BV. Clearance of amyloid-beta by circulating lipoprotein receptors. Nat Med. 2007; 13(9):1029–31. doi:http://​dx.​doi.​org/​10.​1038/​nm1635. Accessed 13 Feb 2016.CrossRefPubMedPubMedCentral

go back to reference Nalivaeva N, Fisk L, Belyaev N, Turner A. Amyloid-degrading enzymes as therapeutic targets in Alzheimers disease. Curr Alzheimer Res. 2008; 5(2):212–24. doi:http://dx.doi.org/10.2174/156720508783954785. Accessed 13 Feb 2016.CrossRefPubMed Nalivaeva N, Fisk L, Belyaev N, Turner A. Amyloid-degrading enzymes as therapeutic targets in Alzheimers disease. Curr Alzheimer Res. 2008; 5(2):212–24. doi:http://​dx.​doi.​org/​10.​2174/​1567205087839547​85. Accessed 13 Feb 2016.CrossRefPubMed

go back to reference Leal MC, Surace EI, Holgado MP, Ferrari CC, Tarelli R, Pitossi F, Wisniewski T, Castano EM, Morelli L. Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: implications for cellular Abeta metabolism. Biochim Biophys Acta. 2012; 1823(2):227–35.CrossRefPubMed Leal MC, Surace EI, Holgado MP, Ferrari CC, Tarelli R, Pitossi F, Wisniewski T, Castano EM, Morelli L. Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: implications for cellular Abeta metabolism. Biochim Biophys Acta. 2012; 1823(2):227–35.CrossRefPubMed

go back to reference Valenti L, Mendoza RM, Rametta R, Maggioni M, Kitajewski C, Shawber CJ, Pajvani UB. Hepatic notch signaling correlates with insulin resistance and nonalcoholic fatty liver disease. Diabetes. 2013; 62(12):4052–62. doi:http://dx.doi.org/10.2337/db13-0769. Accessed 12 Mar 2015.CrossRefPubMedPubMedCentral Valenti L, Mendoza RM, Rametta R, Maggioni M, Kitajewski C, Shawber CJ, Pajvani UB. Hepatic notch signaling correlates with insulin resistance and nonalcoholic fatty liver disease. Diabetes. 2013; 62(12):4052–62. doi:http://​dx.​doi.​org/​10.​2337/​db13-0769. Accessed 12 Mar 2015.CrossRefPubMedPubMedCentral

go back to reference Kang DE, Yoon IS, Repetto E, Busse T, Yermian N, Ie L, Koo EH. Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling. J Biol Chem. 2005; 280(36):31537–47.CrossRefPubMed Kang DE, Yoon IS, Repetto E, Busse T, Yermian N, Ie L, Koo EH. Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling. J Biol Chem. 2005; 280(36):31537–47.CrossRefPubMed

go back to reference McKenzie G, Ward G, Stallwood Y, Briend E, Papadia S, Lennard A, Turner M, Champion B, Hardingham GE. Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals. BMC Cell Biol. 2006; 7:10.CrossRefPubMedPubMedCentral McKenzie G, Ward G, Stallwood Y, Briend E, Papadia S, Lennard A, Turner M, Champion B, Hardingham GE. Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals. BMC Cell Biol. 2006; 7:10.CrossRefPubMedPubMedCentral

go back to reference Calzavara E, Chiaramonte R, Cesana D, Basile A, Sherbet GV, Comi P. Reciprocal regulation of Notch and PI3k/Akt signalling in T-ALL cells in vitro. J Cell Biochem. 2008; 103(5):1405–12.CrossRefPubMed Calzavara E, Chiaramonte R, Cesana D, Basile A, Sherbet GV, Comi P. Reciprocal regulation of Notch and PI3k/Akt signalling in T-ALL cells in vitro. J Cell Biochem. 2008; 103(5):1405–12.CrossRefPubMed

go back to reference Ferreira ST, Clarke JR, Bomfim TR, Felice D, De Felice FG. Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer’s disease. Alzheimer’s Dementia J Alzheimer’s Assoc. 2014; 10(1):76–83. doi:http://dx.doi.org/10.1016/j.jalz.2013.12.010. Accessed 13 May 2014.CrossRef Ferreira ST, Clarke JR, Bomfim TR, Felice D, De Felice FG. Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer’s disease. Alzheimer’s Dementia J Alzheimer’s Assoc. 2014; 10(1):76–83. doi:http://​dx.​doi.​org/​10.​1016/​j.​jalz.​2013.​12.​010. Accessed 13 May 2014.CrossRef

go back to reference De Felice FG, Lourenco MV, Ferreira ST. How does brain insulin resistance develop in Alzheimer’s disease?Alzheimer’s Dementia J Alzheimer’s Assoc. 2014; 10(1):26–32. doi:http://dx.doi.org/10.1016/j.jalz.2013.12.004. Accessed 12 May 2014.CrossRef De Felice FG, Lourenco MV, Ferreira ST. How does brain insulin resistance develop in Alzheimer’s disease?Alzheimer’s Dementia J Alzheimer’s Assoc. 2014; 10(1):26–32. doi:http://​dx.​doi.​org/​10.​1016/​j.​jalz.​2013.​12.​004. Accessed 12 May 2014.CrossRef