Published in:
01-11-2005 | Editorial
Noradrenaline and the kidney: foe, friend, or both?
Authors:
Martin Matejovic, Karl Träger, Daniel De Backer
Published in:
Intensive Care Medicine
|
Issue 11/2005
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Excerpt
Alterations in organ perfusion and associated organ dysfunction are critical features of septic shock. In this context, the susceptibility of the kidney to hypoperfusion is particularly high [
1]. Among other factors inadequate renal perfusion is recognized as an important factor contributing to the pathogenesis of acute renal dysfunction [
1]. Accordingly, the preservation of sufficient perfusion pressure is an essential prerequisite to preserve renal function. Vasopressors are often used to achieve this goal in patients who fail to respond to volume resuscitation. Surprisingly, although blood pressure constitutes one of the most frequently measured variables in critically ill patients, the exact goal for blood pressure maintenance in septic patients is still a matter of debate. …