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01-01-2018 | Editorial

Non-Inferiority Trials in Medicine: Practice Changing or a Self-Fulfilling Prophecy?

Author: Vinay Prasad, MD, MPH

Published in: Journal of General Internal Medicine | Issue 1/2018

Excerpt

Each week, a practicing physician may read the latest medical journal and find a new intervention claiming to be non-inferior to a therapy she uses, while offering the advantage of freedom from monitoring, lower cost, or less toxicity. In an ideal world, such trials could be accepted at face value, but a growing body of evidence suggests that when it comes to non-inferiority trials: reader beware. …

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Djulbegovic B, Kumar A, Glasziou P, et al. Medical research: trial unpredictability yields predictable therapy gains. Nature. 2013;500(7463):395-96. https://doi.org/10.1038/500395a.CrossRefPubMed

Suda KJ, Hurley AM, McKibbin T, et al. Publication of noninferiority clinical trials: changes over a 20-year interval. Pharmacotherapy. 2011;31(9):833-9. doi: https://doi.org/10.1592/phco.31.9.833 [published Online First: 2011/09/20].CrossRefPubMed

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Title: Non-Inferiority Trials in Medicine: Practice Changing or a Self-Fulfilling Prophecy?
Author: Vinay Prasad, MD, MPH
Publication date: 01-01-2018
Publisher: Springer US
Published in: Journal of General Internal Medicine / Issue 1/2018
Print ISSN: 0884-8734
Electronic ISSN: 1525-1497
DOI: https://doi.org/10.1007/s11606-017-4191-y

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