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Clinical Sarcoma Research
Published in: Clinical Sarcoma Research 1/2018

Open Access 01-12-2018 | Research

Non-canonical WNT6/WNT10A signal factor expression in EBV+ post-transplant smooth muscle tumors

Authors: Kristin Teiken, Mark Kuehnel, Jan Rehkaemper, Hans Kreipe, Florian Laenger, Kais Hussein, Danny Jonigk

Published in: Clinical Sarcoma Research | Issue 1/2018

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Abstract

Post-transplant smooth muscle tumors (PTSMTs) are rare mesenchymal neoplasms which occur after solid organ or haematopoietic stem cell transplantation. PTSMT typically consist of Epstein–Barr-virus (EBV)+ smooth muscle-like cells and show an intermediate malignancy. Their main occurrences are visceral organs, especially the liver, but intracranial appearances are described and associated with a poor prognosis. EBV drives the growth of PTSMT; however, the underlying molecular mechanisms still remain unclear. Gene expression analysis of a set of morphologically similar tumors (leiomyomas, leiomyosarcomas, angioleiomyomas and endothelial haemangiomas) from patients without immunosuppression or EBV-association was performed. Our findings indicate that PTSMT’s growth is driven by two factors of the wingless-type protein family: WNT6 and WNT10A. We are first to report that in PTSMTs, a non-canonical activation of WNT, independent of beta-catenin, drives tumor cell proliferation via MTOR/AKT1, MYC and Cyclin D2.
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Metadata
Title
Non-canonical WNT6/WNT10A signal factor expression in EBV+ post-transplant smooth muscle tumors
Authors
Kristin Teiken
Mark Kuehnel
Jan Rehkaemper
Hans Kreipe
Florian Laenger
Kais Hussein
Danny Jonigk
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Clinical Sarcoma Research / Issue 1/2018
Electronic ISSN: 2045-3329
DOI
https://doi.org/10.1186/s13569-018-0096-8

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