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Intensive Care Medicine
Published in: Intensive Care Medicine 4/2006

01-04-2006 | Correspondence

Nocturnal melatonin concentration is correlated with illness severity in patients with septic disease

Authors: Boris Perras, Volkhard Kurowski, Christoph Dodt

Published in: Intensive Care Medicine | Issue 4/2006

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Excerpt

Sir: Disturbances of pineal function are well known in critically ill humans [1], but it is unclear whether melatonin blood concentrations are related to severity of illness. We measured serum melatonin concentrations at 2 a.m. in the first night in hospital in 302 patients consecutively admitted to the medical ICU of the University Hospital in Lübeck, Germany. At the same time the Acute Physiology And Chronic Health Evaluation (APACHE) II score and Therapeutic Intervention Scoring System (TISS) were assessed. Serum melatonin concentrations were determined by enzyme-linked immunosorbent assay (DPC Biermann, Germany). Correlations between illness severity and serum melatonin concentrations were calculated for the whole group and also for subgroups of patients specified according to the main diagnosis before the study. Results were presented at the annual congress of the ESCIM in Amsterdam, 25 September 2005 [2]. …
Literature
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Olofsson K, Alling C, Lundberg D, Malmros C (2004) Abolished circadian rhythm of melatonin secretion in sedated and artificially ventilated intensive care patients. Acta Anaesthesiol Scand 48:679–684CrossRefPubMed
2.
Perras B, Kurowski V, Dodt C (2005) Nocturnal melatonin concentration correlates with illness severity in patients with septic disease. Intensive Care Med 31:S145
3.
Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G (2003) 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med 29:530–538PubMed
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Gitto E, Karbownik M, Reiter RJ, Tan DX, Cuzzocrea S, Chiurazzi P, Cordaro S, Corona G, Trimarchi G, Barberi I (2001) Effects of melatonin treatment in septic newborns. Pediatr Res 50:756–760PubMedCrossRef
Metadata
Title
Nocturnal melatonin concentration is correlated with illness severity in patients with septic disease
Authors
Boris Perras
Volkhard Kurowski
Christoph Dodt
Publication date
01-04-2006
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 4/2006
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-006-0069-x

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