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Journal of the International Society of Sports Nutrition

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Open Access 01-12-2012 | Short report

No effect of creatine supplementation on oxidative stress and cardiovascular parameters in spontaneously hypertensive rats

Authors: Christiano RR Alves, Igor H Murai, Pamella Ramona, Humberto Nicastro, Luiz RG Bechara, Antonio H Lancha Jr, Patrícia C Brum, Maria C Irigoyen, Bruno Gualano

Published in: Journal of the International Society of Sports Nutrition | Issue 1/2012

Abstract

Background

Exacerbated oxidative stress is thought to be a mediator of arterial hypertension. It has been postulated that creatine (Cr) could act as an antioxidant agent preventing increased oxidative stress. The aim of this study was to investigate the effects of nine weeks of Cr or placebo supplementation on oxidative stress and cardiovascular parameters in spontaneously hypertensive rats (SHR).

Findings

Lipid hydroperoxidation, one important oxidative stress marker, remained unchanged in the coronary artery (Cr: 12.6 ± 1.5 vs. Pl: 12.2 ± 1.7 nmol·mg^-1; p = 0.87), heart (Cr: 11.5 ± 1.8 vs. Pl: 14.6 ± 1.1 nmol·mg^-1; p = 0.15), plasma (Cr: 67.7 ± 9.1 vs. Pl: 56.0 ± 3.2 nmol·mg^-1; p = 0.19), plantaris (Cr: 10.0 ± 0.8 vs. Pl: 9.0 ± 0.8 nmol·mg^-1; p = 0.40), and EDL muscle (Cr: 14.9 ± 1.4 vs. Pl: 17.2 ± 1.5 nmol·mg^-1; p = 0.30). Additionally, Cr supplementation affected neither arterial blood pressure nor heart structure in SHR (p > 0.05).

Conclusions

Using a well-known experimental model of systemic arterial hypertension, this study did not confirm the possible therapeutic effects of Cr supplementation on oxidative stress and cardiovascular dysfunction associated with arterial hypertension.

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Title: No effect of creatine supplementation on oxidative stress and cardiovascular parameters in spontaneously hypertensive rats
Authors: Christiano RR Alves
Igor H Murai
Pamella Ramona
Humberto Nicastro
Luiz RG Bechara
Antonio H Lancha Jr
Patrícia C Brum
Maria C Irigoyen
Bruno Gualano
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Journal of the International Society of Sports Nutrition / Issue 1/2012
Electronic ISSN: 1550-2783
DOI: https://doi.org/10.1186/1550-2783-9-13

Keynote webinar | Spotlight on medication adherence

Springer Medicine

No effect of creatine supplementation on oxidative stress and cardiovascular parameters in spontaneously hypertensive rats

Abstract

Background

Findings

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Findings

Conclusions

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