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International Ophthalmology

Published in:

01-10-2018 | Original Paper

Nitrite, neopterin levels and tryptophan degradation in allergic conjunctivitis

Authors: Emine Cinici, Saziye Sezin Palabiyik, Hande Sipahi, Terken Baydar

Published in: International Ophthalmology | Issue 5/2018

Abstract

Purpose

The study aims to evaluate changes in neopterin levels and tryptophan degradation which are induced by Th1-type immune response and nitric oxide metabolism which may be involved in allergic inflammation.

Methods

Serum nitrite, kynurenine, tryptophan and neopterin levels were evaluated in 36 patients with seasonal allergic conjunctivitis, along with these values in 41 healthy subjects. All these parameters have been compared with symptom and sign scores.

Results

Tryptophan and kynurenine concentrations were not significantly changed, while serum nitrite concentrations were significantly low, and neopterin levels were significantly increased in patients compared to healthy subjects (p < 0.05). There was a significant relationship between symptom scores and serum nitrite levels in patients.

Conclusions

This preliminary study demonstrates that serum nitric oxide metabolism might have a role in allergic conjunctivitis. Serum neopterin levels but not tryptophan metabolism could serve as a biomarker in patients with seasonal allergic conjunctivitis.

Bonini S, Sgrulletta R, Coassin M, Bonini S (2009) Allergic conjunctivitis: update on ıts pathophysiology and perspectives for future treatment. Allergy Front Clin Manif 3:25–48CrossRef

Leonardi A (2013) Allergy and allergic mediators in tears. Exp Eye Res 117:106–117. doi:10.1016/j.exer.2013.07.019 CrossRefPubMed

Abelson MB (1999) Comparison of the conjunctival allergen challenge model with the environmental model of allergic conjunctivitis. Acta Ophthalmol Scand Suppl 228:38–42CrossRef

Leonardi A (1999) Pathophysiology of allergic conjunctivitis. Acta Ophthalmol Scand Suppl 228:21–23CrossRef

Le AV, Broide DH (2006) Indoleamine-2,3-dioxygenase modulation of allergic immune responses. Curr Allergy Asthma Rep 6(1):27–31CrossRefPubMed

Ciprandi G, De Amici M, Tosca M, Fuchs D (2010) Tryptophan metabolism in allergic rhinitis: the effect of pollen allergen exposure. Hum Immunol 71(9):911–915. doi:10.1016/j.humimm.2010.05.017 CrossRefPubMed

Capuron L, Geisler S, Kurz K, Leblhuber F, Sperner-Unterweger B, Fuchs D (2014) Activated immune system and inflammation in healthy ageing: relevance for tryptophan and neopterin metabolism. Curr Pharm Des 20(38):6048–6057CrossRefPubMed

Geisler S, Mayersbach P, Becker K, Schennach H, Fuchs D, Gostner JM (2015) Serum tryptophan, kynurenine, phenylalanine, tyrosine and neopterin concentrations in 100 healthy blood donors. Pteridines 26(1):31–36CrossRef

Schrocksnadel K, Wirleitner B, Winkler C, Fuchs D (2006) Monitoring tryptophan metabolism in chronic immune activation. Clin Chim Acta 364(1–2):82–90CrossRefPubMed

10.

Girgin G, Sahin TT, Fuchs D, Kasuya H, Yuksel O, Tekin E, Baydar T (2009) Immune system modulation in patients with malignant and benign breast disorders: tryptophan degradation and serum neopterin. Int J Biol Mark 24(4):265–270CrossRef

11.

Altindag ZZ, Sahin G, Inanici F, Hascelik Z (1998) Urinary neopterin excretion and dihydropteridine reductase activity in rheumatoid arthritis. Rheumatol Int 18(3):107–111CrossRefPubMed

12.

Palabiyik SS, Keles S, Girgin G, Arpali-Tanas E, Topdagi E, Baydar T (2016) Neopterin release and tryptophan degradation in patients with uveitis. Curr Eye Res. doi:10.3109/02713683.2015.1133830 CrossRefPubMed

13.

Baydar T, Yuksel O, Sahin TT, Dikmen K, Girgin G, Sipahi H, Kurukahvecioglu O, Bostanci H, Sare M (2009) Neopterin as a prognostic biomarker in intensive care unit patients. J Crit Care 24(3):318–321. doi:10.1016/j.jcrc.2008.06.013 CrossRefPubMed

14.

Baydar T, Kemer OE, Kilicarslan B, Cardak A, Girgin G (2016) Detection of neopterin in tear samples. Pteridines 27(1–2):13–16

15.

Palabiyik SS, Girgin G, Tutkun E, Yilmaz OH, Baydar T (2013) Immunomodulation and oxidative stress in denim sandblasting workers: changes caused by silica exposure. Arh Hig Rada Toksikol 64(3):431–437. doi:10.2478/10004-1254-64-2013-2312 CrossRefPubMed

16.

Ko SM, Kim MK, Kim JC (2000) The role of nitric oxide in experimental allergic conjunctivitis. Cornea 19(1):84–91CrossRefPubMed

17.

Samelson-Jones BJ, Yeh SR (2006) Interactions between nitric oxide and indoleamine 2,3-dioxygenase. Biochemistry 45(28):8527–8538. doi:10.1021/bi060143j CrossRefPubMed

18.

Tracey WR, Tse J, Carter G (1995) Lipopolysaccharide-induced changes in plasma nitrite and nitrate concentrations in rats and mice: pharmacological evaluation of nitric oxide synthase inhibitors. J Pharmacol Exp Ther 272(3):1011–1015PubMed

19.

Ciprandi G, Fuchs D (2012) Tryptophan, neopterin, and nitrite in allergy. Allergy 67(8):1083. doi:10.1111/j.1398-9995.2012.02862.x CrossRefPubMed

20.

Kositz C, Schroecksnadel K, Grander G, Schennach H, Kofler H, Fuchs D (2008) High serum tryptophan concentration in pollinosis patients is associated with unresponsiveness to pollen extract therapy. Int Arch Allergy Immunol 147(1):35–40. doi:10.1159/000128584 CrossRefPubMed

21.

Murr C, Widner B, Wirleitner B, Fuchs D (2002) Neopterin as a marker for immune system activation. Curr Drug Metab 3(2):175–187CrossRefPubMed

22.

Raitala A, Karjalainen J, Oja SS, Kosunen TU, Hurme M (2006) Indoleamine 2,3-dioxygenase (IDO) activity is lower in atopic than in non-atopic individuals and is enhanced by environmental factors protecting from atopy. Mol Immunol 43(7):1054–1056. doi:10.1016/j.molimm.2005.06.022 CrossRefPubMed

23.

Buyuktiryaki B, Sahiner UM, Girgin G, Birben E, Soyer OU, Cavkaytar O, Cetin C, Arik Yilmaz E, Yavuz ST, Kalayci O, Baydar T, Sackesen C (2015) Low Indoleamine 2,3-dioxygenase (IDO) activity in persistent food allergy in children. Allergy. doi:10.1111/all.12785 CrossRefPubMed

24.

Ciprandi G, Tosca M, Fuchs D (2011) Nitric oxide metabolites in allergic rhinitis: the effect of pollen allergen exposure. Allergol Immunopathol (Madr) 39(6):326–329. doi:10.1016/j.aller.2011.01.001 CrossRef

25.

Unal M, Eskandari HG, Ercetin N, Dogruer ZN, Pata YS (2007) Serum nitrite/nitrate and arginase levels in patients with allergic rhinitis. ORL J Otorhinolaryngol Relat Spec 69(2):113–115. doi:10.1159/000097842 CrossRefPubMed

Title: Nitrite, neopterin levels and tryptophan degradation in allergic conjunctivitis
Authors: Emine Cinici
Saziye Sezin Palabiyik
Hande Sipahi
Terken Baydar
Publication date: 01-10-2018
Publisher: Springer Netherlands
Published in: International Ophthalmology / Issue 5/2018
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-017-0669-1

At a glance: The STEP trials

Springer Medicine

Nitrite, neopterin levels and tryptophan degradation in allergic conjunctivitis

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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