Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Pediatric Nephrology
Published in: Pediatric Nephrology 11/2005

01-11-2005 | Original Article

Nitric oxide modulates renal vasoconstrictor effect of endothelin-1 in conscious lambs

Authors: Francine G. Smith, Liesbeth van der Velde, Alp Sener

Published in: Pediatric Nephrology | Issue 11/2005

Login to get access

Abstract

To test the hypothesis that nitric oxide (NO) buffers the renal vasoconstrictor effects of endothelin-1 (ET-1) early in life, renal haemodynamic responses to ET-1 were measured in the presence and absence of endogenously produced NO in conscious lambs. Renal haemodynamic effects of ET-1 were measured for 5 min before (control) and 20 min after intraarterial injection of ET-1 before and after pretreatment with 20 mg/kg of the l-arginine analogue NG-nitro-l-arginine methyl ester (l-NAME), (experiment 1) and its inactive isomer D-NAME (experiment 2) in conscious lambs aged ~1 week (N=7) and ~6 weeks (N=6). The two experiments were carried out in random order at intervals of 24–48 h. In lambs aged ~6 weeks, a marked increase in renal vascular resistance (RVR) was elicited by ET-1 administration; this response was enhanced twofold following pretreatment with l-NAME. In 1-week-old lambs, however, an increase in RVR in response to ET-1 occurred only after pretreatment with l-NAME. Therefore, we accept our hypothesis and conclude that NO buffers the renal vasoconstrictor effects of ET-1 early in life.
Literature
1.
Yanagisawa M, Kurihara H, Kimura S, et al. (1988) A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332:411–415CrossRefPubMed
2.
3.
King AJ, Brenner BM, Anderson S (1989) Endothelin: a potent renal and systemic vasoconstrictor peptide. Am J Physiol 256:F1051-F1058PubMed
4.
Eriksson S, Andersson B, Gunnarsson U, Rundgren M (1994) Hypertension and thirst outlasting renal vasoconstriction as effects of a brief elevation of systemic angiotensin II in sheep. Acta Physiol Scand 150:181–188PubMed
5.
Chou S-Y, Porush JG (1995) Renal actions of endothelin-1 and endothelin-3: Interactions with the prostaglandin system and nitric oxide. Am J Kidney Dis 26:116–123PubMed
6.
Smith FG, Nohara N, Patel A, Sener A (2002) Endothelin-1 (ET-1) produces no renal vasoconstriction in conscious newborn lambs. Pediatr Nephrol 17:889–895CrossRefPubMed
7.
Abadie L, Blazy I, Roubert P, et al. (1996) Decrease in endothelin-1 renal receptors during the 1st month of life in the rat. Pediatr Nephrol 10:185–189PubMed
8.
Becker K, Erdbrügger W, Heinroth-Hoffmann I, et al. (1996) Endothelin-induced inositol phophate formation in rat kidney. Studies on receptor subtypes, G-proteins and regulation during ontogenesis. Naunyn-Schmiedeberg’s Arch Pharmacol 354:572–578
9.
Hocher B, Rohmeiss P, Dickmann F, et al. (1995) Distribution of endothelin receptor subtypes in the rat kidney. Renal and haemodynamic effects of the mixed (A/B) endothelin receptor antagonist bosentan. Eur J Clin Chem Clin Biochem 33:463–472PubMed
10.
Docherty CC, Kalmar-Nagy J, Engelen M, Nathanielsz PW (2001) Development of fetal vascular responses to endothelin-1 and acetylcholine in the sheep. Am J Physiol Regul Integr Comp Physiol 280:R554-R562PubMed
11.
Sener A, Smith FG (1999) Acetylcholine chloride and renal haemodynamics during postnatal maturation in conscious lambs. J Appl Physiol 87:1296–1300PubMed
12.
Török J, Gerová M (1997) Developmental dynamics of endothelial and neurogenic control of canine thoracic aorta. Mech Ageing Devel 95:143–152CrossRef
13.
Sener A, Smith FG (2001) Renal hemodynamic effects of l-NAME during postnatal maturation in conscious lambs. Pediatr Nephrol 16:868–873CrossRefPubMed
14.
Sener A, Smith FG (2002) Glomerular and tubular responses to NG-nitro-l-arginine methyl ester are age-dependent in conscious lambs. Am J Physiol Regul Integr Comp Physiol 282:R1512-R1520PubMed
15.
Sener A, Smith FG (1999) Dose dependent effects of nitric oxide synthase inhibition on systemic and renal haemodynamics in conscious lambs. Can J Physiol Pharmacol 77:1–7CrossRefPubMed
16.
Solhaug MJ, Ballèvre L, Guignard J-P, et al. (1996) Nitric oxide in the developing kidney. Pediatr Nephrol 10:529–539CrossRefPubMed
17.
de Wildt SN, Smith FG (1997) Effects of the angiotensin converting enzyme (ACE) inhibitor, captopril, on the cardiovascular, endocrine and renal responses to furosemide in conscious lambs. Can J Physiol Pharmacol 75:263–270CrossRefPubMed
18.
Yanagisawa M, Inoue A, Ishikawa T, et al. (1988) Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide. Proc Natl Acad Sci USA 85:6964–6967PubMed
19.
King AJ, Brenner BM (1992) Renal and systemic hemodynamic actions of endothelin. In: Rubanyi GM (ed) Endothelin. Oxford University Press, New York, pp 158–178
20.
Ahlborg G, Ottosson-Seeberger A, Hemsen A, Lundberg JM (1994) Big ET-1 infusion in man causes renal ET-1 release, renal and splanchnic vasoconstriction, and increased mean arterial blood pressure. Cardiovasc Res 28:1559–1563PubMed
21.
Miller WL, Redfield MM, Burnett Jr JC (1989) Integrated cardiac, renal, and endocrine actions of endothelin. J Clin Invest 83:317–320PubMed
22.
Katoh T, Chang H, Uchida S, et al. (1990) Direct effects of endothelin in the rat kidney. Am J Physiol 258:F397-F402PubMed
23.
Yokokawa K, Kohno M, Murakawa K, et al. (1989) Acute effects of endothelin on renal hemodynamics and blood pressure in anesthetized rats. Am J Hypertens 2:715–717PubMed
24.
Pernow J, Boutier,J-F, Franco-Cereceda A, et al. (1988) Potent selective vasoconstrictor effects of endothelin in the pig kidney in vivo. Acta Physiol Scand 134:573–574PubMed
25.
Hirata Y, Matsuoka H, Kimura K, et al. (1989) Renal vasoconstriction by the endothelial cell-derived peptide endothelin in spontaneously hypertensive rats. Circ Res 65:1370–1379PubMed
26.
Pernow JP, Hemsen A, Lundberg JM (1989) Tissue specific distribution, clearance and vascular effects of endothelin in the pig. Biochem Biophys Res Commun 161:647–653CrossRefPubMed
27.
Anggard E, Galton S, Rae G, et al. (1989) The fate of radioiodinated endothelin-1 and endothelin-3 in the rat. J Cardiovasc Pharmacol 13:S46-S49PubMed
28.
Warner TD (1999) Relationships between the endothelin and nitric oxide pathways. Clin Exp Pharmacol Physiol 26:247–252CrossRefPubMed
29.
30.
Wiley KE, Davenport AP (2001) Nitric oxide-mediated modulation of the endothelin-1 signalling pathway in the human cardiovascular system. Br J Pharmacol 132:213–220CrossRefPubMed
31.
La M, Reid JJ (1995) Endothelin-1 and the regulation of vascular tone. Clin Exp Pharmacol Physiol 22:315–322PubMed
32.
Lüscher TF, Yong Z, Tschudi M, et al. (1990) Interaction between endothelin-1 and endothelium-derived relaxing factor in human arteries and veins. Circ Res 66:1088–1094PubMed
33.
Garcia JL, Fernandez N, Garcia-Villalon AL, et al. (1996) Coronary vasoconstriction by endothelin-1 in anesthetized goats: role of endothelin receptors, nitric oxide and prostanoids. Eur J Pharmacol 315:179–186CrossRefPubMed
34.
Baylis C (1999) Acute interactions between endothelin and nitric oxide in the control of renal hemodynamics. Clin Exp Pharmacol Physiol 26:253–257CrossRefPubMed
35.
Lin H, Smith Jr. MJ, Young DB (1996) Roles of prostaglandins and nitric oxide in the effect of endothelin-1 on renal hemodynamics. Hypertension 28:372–378PubMed
36.
Cairns HS, Rogerson ME, Fairbanks LD, et al. (1989) Endothelin induces an increase in renal vascular resistance and a fall in glomerular filtration rate in the rabbit isolated perfused kidney. Br J Pharmacol 98:155–160PubMed
37.
Rogerson ME, Cairns HS, Fairbanks LD, et al. (1993) Endothelin-1 in the rabbit: interactions with cyclo-oxygenase and NO-synthase products. Br J Pharmacol 108:838–843PubMed
38.
Madeddu P, Anania V, Parpaglia PP, et al. (1991). Endothelin-1 induced renal vasoconstriction is blunted by enalaprilat and enhanced by EDRF antagonist in awake normotensive rats. Clin Invest Med 14:600–606PubMed
39.
Gellai M, de Wolf R, Fletcher T, Nambi P (1997) Contribution of endogenous endothelin-1 to the maintenance of vascular tone: role of nitric oxide. Pharmacology 55:299–308PubMed
40.
Le Monnier de Gouville AC, Lippton H, Hyman A, Cavero I (1989) NG-monomethyl-l-arginine does not inhibit the hindquarters vasodilator action of endothelin-1 in conscious rats. Eur J Pharmacol 171:237–240CrossRefPubMed
41.
Ovadia B, Bekker JM, Fitzgerald RK, et al. (2002) Nitric oxide-endothelin-1 interactions after acute ductal constriction in fetal lambs. Am J Physiol Heart Circ Physiol 282:H862-H871PubMed
42.
Perreault T, De Marte J (1993) Maturational changes in endothelium-derived relaxations in newborn piglet pulmonary circulation. Am J Physiol Heart Circ Physiol 264:H302-H309
43.
Bogaert GA, Kogan BA, Mevorach RA, et al. (1996) Exogenous endothelin-1 causes renal vasodilation in the fetal lamb. J Urol 156:847–853CrossRefPubMed
Metadata
Title
Nitric oxide modulates renal vasoconstrictor effect of endothelin-1 in conscious lambs
Authors
Francine G. Smith
Liesbeth van der Velde
Alp Sener
Publication date
01-11-2005
Publisher
Springer-Verlag
Published in
Pediatric Nephrology / Issue 11/2005
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-005-2015-5

Other articles of this Issue 11/2005

Pediatric Nephrology 11/2005 Go to the issue

Original Article

Detection of enteroviruses in renal biopsies from patients with immunoglobulin A nephropathy

Original Article

Plasma and urine nitric oxide levels in healthy Turkish children

Original Article

Acute renal failure in Nigerian children: Port Harcourt experience

Original Article

Role of folate deficiency on erythropoietin resistance in pediatric and adolescent patients on chronic dialysis

Brief Report

Therapeutic total plasma exchange in a child with neuroblastoma-related anti-Hu syndrome

Original Article

Community-acquired enterococcal urinary tract infections