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01-09-2019 | Original Article

Nigrostriatal and mesolimbic control of sleep–wake behavior in rat

Authors: Mei-Hong Qiu, Zhi-Gang Zhong, Michael C. Chen, Jun Lu

Published in: Brain Structure and Function | Issue 7/2019

Abstract

The midbrain dopamine system via the dorsal and ventral striatum regulates a wide range of behaviors. To dissect the role of dopaminergic projections to the dorsal striatum (nigrostriatal projection) and ventral striatum (mesolimbic projection) in sleep–wake behavior, we selectively chemogenetically stimulated nigrostriatal or mesolimbic projections and examined the resulting effects on sleep in rats. Stimulation of nigrostriatal pathways increased sleep and EEG delta power, while stimulation of mesolimbic pathways decreased sleep and reduced cortical EEG power. These results indicate that midbrain dopamine signaling in the dorsal or ventral striatum promotes sleep or wake, respectively.

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Title: Nigrostriatal and mesolimbic control of sleep–wake behavior in rat
Authors: Mei-Hong Qiu
Zhi-Gang Zhong
Michael C. Chen
Jun Lu
Publication date: 01-09-2019
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 7/2019
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-019-01921-w

At a glance: The STEP trials

Springer Medicine

Nigrostriatal and mesolimbic control of sleep–wake behavior in rat

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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