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International Journal of Pediatric Endocrinology
Published in: International Journal of Pediatric Endocrinology 1/2012

Open Access 01-12-2012 | Review

New technologies for diabetes: a review of the present and the future

Authors: Neesha Ramchandani, Rubina A Heptulla

Published in: International Journal of Pediatric Endocrinology | Issue 1/2012

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Abstract

This review summarizes the technologies in use and in the pipeline for the management of diabetes. The review focuses on glucose meters, continuous glucose monitoring devices, insulin pumps, and getting clinicians connected to technologies. All information presented can be found in the public domain, and was obtained from journal articles, websites, product review tables in patient publications, and professional conferences. The technology concerns, ongoing development and future trends in this area are also discussed.
Literature
1.
2.
3.
Lyon ME, Baskin LB, Braakman S, Presti S, Dubois J, Shirey T: Interference studies with two hospital-grade and two home-grade glucose meters. Diabetes Technol Ther. 2009, 11: 641-647. 10.1089/dia.2009.0035.CrossRefPubMed
4.
Heinemann L: Quality of glucose measurement with blood glucose meters at the point-of-care: relevance of interfering factors. Diabetes Technol Ther. 2010, 12: 847-857. 10.1089/dia.2010.0076.CrossRefPubMed
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
Tura A, Maran A, Pacini G: Non-invasive glucose monitoring: assessment of technologies and devices according to quantitative criteria. Diabetes Res Clin Pract. 2007, 77: 16-40. 10.1016/j.diabres.2006.10.027.CrossRefPubMed
25.
26.
27.
28.
29.
CareLink Personal Therapy Management Software for Diabetes. available from carelink.minimed.com
30.
Mamkin I, Ten S, Bhandari S, Ramchandani N: Real-time continuous glucose monitoring in the clinical setting: the good, the bad, and the practical. J Diabetes Sci Technol. 2008, 2: 882-889.PubMedCentralCrossRefPubMed
31.
Kovatchev BP, Gonder-Frederick LA, Cox DJ, Clarke WL: Evaluating the accuracy of continuous glucose-monitoring sensors: continuous glucose-error grid analysis illustrated by TheraSense Freestyle Navigator data. Diabetes Care. 2004, 27: 1922-1928. 10.2337/diacare.27.8.1922.CrossRefPubMed
32.
Bode B, Gross K, Rikalo N, Schwartz S, Wahl T, Page C: Alarms based on real-time sensor glucose values alert patients to hypo- and hyperglycemia: the guardian continuous monitoring system. Diabetes Technol Ther. 2004, 6: 105-113. 10.1089/152091504773731285.CrossRefPubMed
33.
Gandrud LM, Xing D, Kollman C, Block JM, Kunselman B, Wilson DM: The Medtronic Minimed Gold continuous glucose monitoring system: an effective means to discover hypo- and hyperglycemia in children under 7 years of age. Diabetes Technol Ther. 2007, 9: 307-316. 10.1089/dia.2007.0026.CrossRefPubMed
34.
Diabetes Research in Children Network Study G: The accuracy of the CGMS in children with type 1 diabetes: results of the diabetes research in children network (DirecNet) accuracy study. Diabetes Technol Ther. 2003, 5: 781-789.CrossRef
35.
Garg S, Zisser H, Schwartz S, Bailey T, Kaplan R, Ellis S: Improvement in glycemic excursions with a transcutaneous, real-time continuous glucose sensor: a randomized controlled trial. Diabetes Care. 2006, 29: 44-50. 10.2337/diacare.29.01.06.dc05-1686.CrossRefPubMed
36.
Maia FF, Araujo LR: [Accuracy, utility and complications of continuous glucose monitoring system (CGMS) in pediatric patients with type 1 diabetes]. J Pediatr. 2005, 81: 293-297.CrossRef
37.
Deiss D, Bolinder J, Riveline JP, Battelino T, Bosi E, Tubiana-Rufi N: Improved glycemic control in poorly controlled patients with type 1 diabetes using real-time continuous glucose monitoring. Diabetes Care. 2006, 29: 2730-2732. 10.2337/dc06-1134.CrossRefPubMed
38.
Bailey TS, Zisser HC, Garg SK: Reduction in hemoglobin A1C with real-time continuous glucose monitoring: results from a 12-week observational study. Diabetes Technol Ther. 2007, 9: 203-210. 10.1089/dia.2007.0205.CrossRefPubMed
39.
Hirsch IB, Abelseth J, Bode BW, Fischer JS, Kaufman FR, Mastrototaro J: Sensor-augmented insulin pump therapy: results of the first randomized treat-to-target study. Diabetes Technol Ther. 2008, 10: 377-383. 10.1089/dia.2008.0068.CrossRefPubMed
40.
Study G, Tamborlane WV, Beck RW, Bode BW, Buckingham B, Chase HP, Juvenile Diabetes Research Foundation Continuous Glucose Monitoring: Continuous glucose monitoring and intensive treatment of type 1 diabetes. N Engl J Med. 2008, 359: 1464-1476.CrossRef
41.
Raccah D, Sulmont V, Reznik Y, Guerci B, Renard E, Hanaire H: Incremental value of continuous glucose monitoring when starting pump therapy in patients with poorly controlled type 1 diabetes: the RealTrend study. Diabetes Care. 2009, 32: 2245-2250. 10.2337/dc09-0750.PubMedCentralCrossRefPubMed
42.
T D: Continuous glucose monitoring. 2009, New Orleans, LA: American Diabetes Association 69th Scientific Sessions
43.
Study G, Buckingham B, Beck RW, Tamborlane WV, Xing D, Kollman C, Diabetes Research in Children Network: Continuous glucose monitoring in children with type 1 diabetes. J Pediatr. 2007, 151: 388-393. 93 e1-2CrossRef
44.
Study G, Weinzimer S, Xing D, Tansey M, Fiallo-Scharer R, Mauras N, Diabetes Research in Children Network: Prolonged use of continuous glucose monitors in children with type 1 diabetes on continuous subcutaneous insulin infusion or intensive multiple-daily injection therapy. Pediatr Diabetes. 2009, 10: 91-96.CrossRef
45.
Bergenstal RM, Tamborlane WV, Ahmann A, Buse JB, Dailey G, Davis SN: Effectiveness of sensor-augmented insulin-pump therapy in type 1 diabetes. N Engl J Med. 2010, 363: 311-320. 10.1056/NEJMoa1002853.CrossRefPubMed
46.
Bergenstal RM, Tamborlane WV, Ahmann A, Buse JB, Dailey G, Davis SN: Sensor-augmented pump therapy for A1C reduction (STAR 3) study: results from the 6-month continuation phase. Diabetes Care. 2011, 34: 2403-2405. 10.2337/dc11-1248.PubMedCentralCrossRefPubMed
47.
Ramchandani N, Arya S, Ten S, Bhandari S: Real-life utilization of real-time continuous glucose monitoring: the complete picture. J Diabetes Sci Technol. 2011, 5: 860-870.PubMedCentralCrossRefPubMed
48.
49.
50.
51.
Saxl T, Khan F, Ferla M, Birch D, Pickup J: A fluorescence lifetime-based fibre-optic glucose sensor using glucose/galactose-binding protein. Analyst. 2011, 136: 968-972. 10.1039/c0an00430h.CrossRefPubMed
52.
Conference Proceedings: Ninth Annual Diabetes Technology Meeting, San Francisco, CA. 2009
53.
Wang W, Li Z, Zheng W, Dong B, Li S, Wang C: A novel non-enzymatic glucose sensor based on nickel (II) oxide electrospun nanofibers. J Nanosci Nanotechnol. 2010, 10: 7537-7540. 10.1166/jnn.2010.2809.CrossRefPubMed
54.
Nie H, Yao Z, Zhou X, Yang Z, Huang S: Nonenzymatic electrochemical detection of glucose using well-distributed nickel nanoparticles on straight multi-walled carbon nanotubes. Biosens Bioelectron. 2011, 30: 28-34. 10.1016/j.bios.2011.08.022.CrossRefPubMed
55.
Johannessen E, Krushinitskaya O, Sokolov A, Philipp H, Hoogerwerf A, Hinderling C: Toward an injectable continuous osmotic glucose sensor. J Diabetes Sci Technol. 2010, 4: 882-892.PubMedCentralCrossRefPubMed
56.
Joseph JI, Hipszer B: Real-time glucose monitoring in the hospital: future or now?. Adv Surg. 2010, 44: 165-184. 10.1016/j.yasu.2010.05.016.CrossRefPubMed
57.
Kowalski AJ: Can we really close the loop and how soon? Accelerating the availability of an artificial pancreas: a roadmap to better diabetes outcomes. Diabetes Technol Ther. 2009, 11 (Suppl 1): S113-S119.PubMed
58.
Tamborlane WV: Fulfilling the promise of insulin pump therapy in childhood diabetes. Pediatr Diabetes. 2006, 7 (Suppl 4): 4-10.CrossRefPubMed
59.
Willi SM, Planton J, Egede L, Schwarz S: Benefits of continuous subcutaneous insulin infusion in children with type 1 diabetes. J Pediatr. 2003, 143: 796-801. 10.1067/S0022-3476(03)00579-1.CrossRefPubMed
60.
Boland EA, Grey M, Oesterle A, Fredrickson L, Tamborlane WV: Continuous subcutaneous insulin infusion. A new way to lower risk of severe hypoglycemia, improve metabolic control, and enhance coping in adolescents with type 1 diabetes. Diabetes Care. 1999, 22: 1779-1784. 10.2337/diacare.22.11.1779.CrossRefPubMed
61.
Sulli N, Shashaj B: Long-term benefits of continuous subcutaneous insulin infusion in children with Type 1 diabetes: a 4-year follow-up. Diabet Med J Br Diabet Assoc. 2006, 23: 900-906. 10.1111/j.1464-5491.2006.01935.x.CrossRef
62.
Jakisch BI, Wagner VM, Heidtmann B, Lepler R, Holterhus PM, Kapellen TM: Comparison of continuous subcutaneous insulin infusion (CSII) and multiple daily injections (MDI) in paediatric Type 1 diabetes: a multicentre matched-pair cohort analysis over 3 years. Diabet Med J Br Diabet Assoc. 2008, 25: 80-85. 10.1111/j.1464-5491.2007.02311.x.CrossRef
63.
Scrimgeour L, Cobry E, McFann K, Burdick P, Weimer C, Slover R: Improved glycemic control after long-term insulin pump use in pediatric patients with type 1 diabetes. Diabetes Technol Ther. 2007, 9: 421-428. 10.1089/dia.2007.0214.CrossRefPubMed
64.
Danne T, von Schutz W, Lange K, Nestoris C, Datz N, Kordonouri O: Current practice of insulin pump therapy in children and adolescents - the Hannover recipe. Pediatr Diabetes. 2006, 7 (Suppl 4): 25-31.CrossRefPubMed
65.
Tamborlane WV, Sikes KA, Steffen AT, Weinzimer SA: Continuous subcutaneous insulin infusion (CSII) in children with type 1 diabetes. Diabetes Res Clin Pract. 2006, 74 (Suppl 2): S112-S115.CrossRefPubMed
66.
Tamborlane WV, Fredrickson LP, Ahern JH: Insulin pump therapy in childhood diabetes mellitus: guidelines for use. Treat Endocrinol. 2003, 2: 11-21. 10.2165/00024677-200302010-00002.CrossRefPubMed
67.
Pickup JC, Sutton AJ: Severe hypoglycaemia and glycaemic control in Type 1 diabetes: meta-analysis of multiple daily insulin injections compared with continuous subcutaneous insulin infusion. Diabet Med J Br Diabet Assoc. 2008, 25: 765-774. 10.1111/j.1464-5491.2008.02486.x.CrossRef
68.
Hanas R, Adolfsson P: Insulin pumps in pediatric routine care improve long-term metabolic control without increasing the risk of hypoglycemia. Pediatr Diabetes. 2006, 7: 25-31.CrossRefPubMed
69.
Danne T, Battelino T, Kordonouri O, Hanas R, Klinkert C, Ludvigsson J: A cross-sectional international survey of continuous subcutaneous insulin infusion in 377 children and adolescents with type 1 diabetes mellitus from 10 countries. Pediatr Diabetes. 2005, 6: 193-198. 10.1111/j.1399-543X.2005.00131.x.CrossRefPubMed
70.
Doyle EA, Weinzimer SA, Steffen AT, Ahern JA, Vincent M, Tamborlane WV: A randomized, prospective trial comparing the efficacy of continuous subcutaneous insulin infusion with multiple daily injections using insulin glargine. Diabetes Care. 2004, 27: 1554-1558. 10.2337/diacare.27.7.1554.CrossRefPubMed
71.
Jeha GS, Karaviti LP, Anderson B, Smith EO, Donaldson S, McGirk TS: Insulin pump therapy in preschool children with type 1 diabetes mellitus improves glycemic control and decreases glucose excursions and the risk of hypoglycemia. Diabetes Technol Ther. 2005, 7: 876-884. 10.1089/dia.2005.7.876.CrossRefPubMed
72.
Saha ME, Huuppone T, Mikael K, Juuti M, Komulainen J: Continuous subcutaneous insulin infusion in the treatment of children and adolescents with type 1 diabetes mellitus. J Pediatr Endocrinol Metab JPEM. 2002, 15: 1005-1010.CrossRefPubMed
73.
Shehadeh N, Battelino T, Galatzer A, Naveh T, Hadash A, de Vries L: Insulin pump therapy for 1–6 year old children with type 1 diabetes. Israel Med Assoc J IMAJ. 2004, 6: 284-286.PubMed
74.
Weinzimer SA, Doyle EA, Steffen AT, Sikes KA, Tamborlane WV: Rediscovery of insulin pump treatment of childhood type 1 diabetes. Minerva Med. 2004, 95: 85-92.PubMed
75.
Weinzimer SA, Ahern JH, Doyle EA, Vincent MR, Dziura J, Steffen AT: Persistence of benefits of continuous subcutaneous insulin infusion in very young children with type 1 diabetes: a follow-up report. Pediatrics. 2004, 114: 1601-1605. 10.1542/peds.2004-0092.CrossRefPubMed
76.
Maahs DM, Horton LA, Chase HP: The use of insulin pumps in youth with type 1 diabetes. Diabetes Technol Ther. 2010, 12 (Suppl 1): S59-S65.PubMed
77.
Danne T, Battelino T, Jarosz-Chobot P, Kordonouri O, Pankowska E, Ludvigsson J: Establishing glycaemic control with continuous subcutaneous insulin infusion in children and adolescents with type 1 diabetes: experience of the PedPump Study in 17 countries. Diabetologia. 2008, 51: 1594-1601. 10.1007/s00125-008-1072-2.CrossRefPubMed
78.
Pickup J: Insulin pumps. International journal of clinical practice Supplement. 2011, 16-19.
79.
Pickup JC, Renard E: Long-acting insulin analogs versus insulin pump therapy for the treatment of type 1 and type 2 diabetes. Diabetes Care. 2008, 31 (Suppl 2): S140-S145.CrossRefPubMed
80.
DiMeglio LA, Pottorff TM, Boyd SR, France L, Fineberg N, Eugster EA: A randomized, controlled study of insulin pump therapy in diabetic preschoolers. J Pediatr. 2004, 145: 380-384. 10.1016/j.jpeds.2004.06.022.CrossRefPubMed
81.
Weintrob N, Benzaquen H, Galatzer A, Shalitin S, Lazar L, Fayman G: Comparison of continuous subcutaneous insulin infusion and multiple daily injection regimens in children with type 1 diabetes: a randomized open crossover trial. Pediatrics. 2003, 112: 559-564. 10.1542/peds.112.3.559.CrossRefPubMed
82.
Wilson DM, Buckingham BA, Kunselman EL, Sullivan MM, Paguntalan HU, Gitelman SE: A two-center randomized controlled feasibility trial of insulin pump therapy in young children with diabetes. Diabetes Care. 2005, 28: 15-19. 10.2337/diacare.28.1.15.CrossRefPubMed
83.
Nabhan ZM, Kreher NC, Greene DM, Eugster EA, Kronenberger W, DiMeglio LA: A randomized prospective study of insulin pump vs. insulin injection therapy in very young children with type 1 diabetes: 12-month glycemic, BMI, and neurocognitive outcomes. Pediatr Diabetes. 2009, 10: 202-208. 10.1111/j.1399-5448.2008.00494.x.CrossRefPubMed
84.
Shalitin S, Phillip M: The use of insulin pump therapy in the pediatric age group. Horm Res. 2008, 70: 14-21. 10.1159/000129673.CrossRefPubMed
85.
Bode BW, Tamborlane WV, Davidson PC: Insulin pump therapy in the 21st century. Strategies for successful use in adults, adolescents, and children with diabetes. Postgrad Med. 2002, 111: 69-77. quiz 27CrossRefPubMed
86.
Bode BW, Sabbah HT, Gross TM, Fredrickson LP, Davidson PC: Diabetes management in the new millennium using insulin pump therapy. Diabetes Metab Res Rev. 2002, 18 (Suppl 1): S14-S20.CrossRefPubMed
87.
Hofer SE, Heidtmann B, Raile K, Frohlich-Reiterer E, Lilienthal E, Berghaeuser MA: Discontinuation of insulin pump treatment in children, adolescents, and young adults. A multicenter analysis based on the DPV database in Germany and Austria. Pediatr Diabetes. 2010, 11: 116-121. 10.1111/j.1399-5448.2009.00546.x.CrossRefPubMed
88.
de Vries L, Grushka Y, Lebenthal Y, Shalitin S, Phillip M: Factors associated with increased risk of insulin pump discontinuation in pediatric patients with type 1 diabetes. Pediatr Diabetes. 2011, 12: 506-512. 10.1111/j.1399-5448.2010.00701.x.CrossRefPubMed
89.
Attia N, Jones TW, Holcombe J, Tamborlane WV: Comparison of human regular and lispro insulins after interruption of continuous subcutaneous insulin infusion and in the treatment of acutely decompensated IDDM. Diabetes Care. 1998, 21: 817-821. 10.2337/diacare.21.5.817.CrossRefPubMed
90.
Reichel A, Rietzsch H, Kohler HJ, Pfutzner A, Gudat U, Schulze J: Cessation of insulin infusion at night-time during CSII-therapy: comparison of regular human insulin and insulin lispro. Exp Clin Endocrinol Diabet Offic J German Soc Endocrinol German Diabet Assoc. 1998, 106: 168-172.CrossRef
91.
Egger M, Davey Smith G, Stettler C, Diem P: Risk of adverse effects of intensified treatment in insulin-dependent diabetes mellitus: a meta-analysis. Diabet Med J Brit Diabet Assoc. 1997, 14: 919-928. 10.1002/(SICI)1096-9136(199711)14:11<919::AID-DIA456>3.0.CO;2-A.CrossRef
92.
93.
94.
95.
96.
97.
98.
99.
100.
101.
102.
103.
104.
105.
Anhalt H, Bohannon NJ: Insulin patch pumps: their development and future in closed-loop systems. Diabetes Technol Ther. 2010, 12 (Suppl 1): S51-S58.PubMed
106.
107.
108.
Harsch IA: Inhaled insulins: their potential in the treatment of diabetes mellitus. Treat Endocrinol. 2005, 4: 131-138. 10.2165/00024677-200504030-00001.CrossRefPubMed
109.
Becquemin MH, Chaumuzeau JP: Inhaled insulin: a model for pulmonary systemic absorption?. Rev Mal Respir. 2010, 27: e54-e65. 10.1016/j.rmr.2010.04.004.CrossRefPubMed
110.
Heinemann L: New ways of insulin delivery. International journal of clinical practice Supplement. 2011, 31-46.
111.
Potocka E, Baughman RA, Derendorf H: Population pharmacokinetic model of human insulin following different routes of administration. J Clin Pharmacol. 2011, 51: 1015-1024. 10.1177/0091270010378520.CrossRefPubMed
112.
Inhaled insulin no longer marketed: discontinuation: Welcome news. Prescrire Int. 2008, 17: 139-
113.
Neumiller JJ, Campbell RK, Wood LD: A review of inhaled technosphere insulin. Ann Pharmacother. 2010, 44: 1231-1239. 10.1345/aph.1P055.CrossRefPubMed
114.
Hisasue J, Fukuyama S, Nakagaki N, Moriwaki A, Inoue S, Sakurada N: Inhalative administration of insulin using a new bubble jet atomization device. Fukuoka Igaku Zasshi Hukuoka Acta Med. 2011, 102: 215-222.PubMed
115.
Depreter F, Burniat A, Blocklet D, Lacroix S, Cnop M, Fery F: Comparative pharmacoscintigraphic and pharmacokinetic evaluation of two new formulations of inhaled insulin in type 1 diabetic patients. Eur J Pharm Biopharm Offic J Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik eV. 2012, 80: 4-13.
116.
Pozzilli P, Raskin P, Parkin CG: Review of clinical trials: update on oral insulin spray formulation. Diabetes Obes Metab. 2010, 12: 91-96. 10.1111/j.1463-1326.2009.01127.x.CrossRefPubMed
117.
Warnken M, Reitzenstein U, Sommer A, Fuhrmann M, Mayer P, Enzmann H: Characterization of proliferative effects of insulin, insulin analogues and insulin-like growth factor-1 (IGF-1) in human lung fibroblasts. Naunyn Schmiedebergs Arch Pharmacol. 2010, 382: 511-524. 10.1007/s00210-010-0561-2.CrossRefPubMed
118.
Lasagna-Reeves CA, Clos AL, Midoro-Hiriuti T, Goldblum RM, Jackson GR, Kayed R: Inhaled insulin forms toxic pulmonary amyloid aggregates. Endocrinology. 2010, 151: 4717-4724. 10.1210/en.2010-0457.CrossRefPubMed
119.
R E, E A, Y M, M K: Evaluation of the safety and efficacy of two oral insulin formulations in healthy volunteers (poster presentation). 2011, Burlingame, CA: Eleventh Annual Diabetes Technology Meeting
120.
Clement S, Dandona P, Still JG, Kosutic G: Oral modified insulin (HIM2) in patients with type 1 diabetes mellitus: results from a phase I/II clinical trial. Metab Clin Exp. 2004, 53: 54-58. 10.1016/j.metabol.2003.07.021.CrossRefPubMed
121.
Card JW, Magnuson BA: A review of the efficacy and safety of nanoparticle-based oral insulin delivery systems. Am J Physiol Gastrointest Liver Physiol. 2011, 301: G956-G967. 10.1152/ajpgi.00107.2011.CrossRefPubMed
122.
Wong TW: Design of oral insulin delivery systems. J Drug Target. 2010, 18: 79-92. 10.3109/10611860903302815.CrossRefPubMed
123.
Yadav N, Morris G, Harding SE, Ang S, Adams GG: Various non-injectable delivery systems for the treatment of diabetes mellitus. Endocr Metab Immune Disord Drug Targets. 2009, 9: 1-13.CrossRefPubMed
124.
Rastogi R, Anand S, Koul V: Electroporation of polymeric nanoparticles: an alternative technique for transdermal delivery of insulin. Drug Dev Ind Pharm. 2010, 36: 1303-1311. 10.3109/03639041003786193.CrossRefPubMed
125.
126.
127.
Qin G, Gao Y, Wu Y, Zhang S, Qiu Y, Li F: Simultaneous basal-bolus delivery of fast-acting insulin and its significance in diabetes management. Nanomed Nanotechnol Biol Med. 2012, 8: 221-227. 10.1016/j.nano.2011.05.017.CrossRef
128.
129.
Metadata
Title
New technologies for diabetes: a review of the present and the future
Authors
Neesha Ramchandani
Rubina A Heptulla
Publication date
01-12-2012
Publisher
BioMed Central
Published in
International Journal of Pediatric Endocrinology / Issue 1/2012
Electronic ISSN: 1687-9856
DOI
https://doi.org/10.1186/1687-9856-2012-28

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