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Published in:

01-03-2005 | Symposium

New Roles of a Neuropeptide Cortistatin in the Immune System and Cancer

Authors: Min Li, Ph.D., Shaoyu Yan, Ph.D., William E. Fisher, M.D., Changyi Chen, M.D., Ph.D., Qizhi Yao, M.D., Ph.D.

Published in: World Journal of Surgery | Issue 3/2005

Abstract

Cortistatin (CST) is a neuropeptide that strongly resembles somatostatin (SS) structurally and functionally. CST binds to all five SS receptors (SSTR1-SSTR5) with high affinity and exerts its function mainly through SSTRs. Despite many similar functions between these two neuropeptides, they are products of different genes. Recently, some distinct functions and receptor usage of CST have been reported. Some of the interesting functions of CST were not found with SS. Therefore CST could have potential new roles in an ex-neuronal system that regulates immune responses as well as other cellular functions in the body. In this review, we discuss the new functions of CST in the immune system, cancer pathogenesis, and possible CST-specific receptors.

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Title: New Roles of a Neuropeptide Cortistatin in the Immune System and Cancer
Authors: Min Li, Ph.D.
Shaoyu Yan, Ph.D.
William E. Fisher, M.D.
Changyi Chen, M.D., Ph.D.
Qizhi Yao, M.D., Ph.D.
Publication date: 01-03-2005
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 3/2005
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-004-7811-8

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Springer Medicine

New Roles of a Neuropeptide Cortistatin in the Immune System and Cancer

Abstract

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Abstract

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