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Breast Cancer Research
Published in: Breast Cancer Research 1/2010

01-05-2010 | Oral presentation

New regulators of the BRCA1 response to genotoxic stress

Authors: JR Morris, C Boutell, M Keppler, R Densham, D Weekes, A Alamshah, L Butler, Y Galanty, L Pangon, T Kiuchi, T Ng, E Solomon

Published in: Breast Cancer Research | Special Issue 1/2010

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Excerpt

The breast and ovarian predisposition protein BRCA1 is a required component of the mammalian response to double-stranded DNA damage. Its conserved BRCT domains are required for BRCA1 accumulation to sites of repair, while the conserved N-terminal RING domain is able to catalyse the conjugation of ubiquitin and act as an E3 ubiquitin ligase. Disruption of either of these domains by missense mutation is associated with disease development. …
Metadata
Title
New regulators of the BRCA1 response to genotoxic stress
Authors
JR Morris
C Boutell
M Keppler
R Densham
D Weekes
A Alamshah
L Butler
Y Galanty
L Pangon
T Kiuchi
T Ng
E Solomon
Publication date
01-05-2010
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue Special Issue 1/2010
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2494

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Keynote webinar | Spotlight on antibody–drug conjugates in cancer

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