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01-03-2015 | Original Article

New expression of 5-HT1A receptor in astrocytes in the gerbil hippocampal CA1 region following transient global cerebral ischemia

Authors: Choong Hyun Lee, Ji Hyeon Ahn, Moo-Ho Won

Published in: Neurological Sciences | Issue 3/2015

Abstract

5-Hydroxytryptamine (5-HT, serotonin) plays protective or detrimental roles in the development of ischemic damage. In the present study, we investigated the time-course changes in 5-HT1A receptor protein expression in the gerbil hippocampal CA1 region after transient global cerebral ischemia. 5-HT1A receptor immunoreactivity in the stratum pyramidale (SP) of the CA1 region was decreased from 6 h and hardly observed 1 and 2 days after ischemic insult. Five and 10 days after ischemia/reperfusion, 5-HT1A receptor immunoreactivity was increased and detected in astrocyte of the ischemic CA1 region. Furthermore, the pattern of changes in 5-HT1A receptor protein levels in the CA1 region after ischemia–reperfusion was similar to that observed in the immunohistochemical data. These results indicate that 5-HT1A receptor protein expressions may be related with the ischemia-induced neuronal death and the function of astrocytes in the ischemic hippocampal CA1 region.

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Title: New expression of 5-HT1A receptor in astrocytes in the gerbil hippocampal CA1 region following transient global cerebral ischemia
Authors: Choong Hyun Lee
Ji Hyeon Ahn
Moo-Ho Won
Publication date: 01-03-2015
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 3/2015
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-014-1958-3

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New expression of 5-HT1A receptor in astrocytes in the gerbil hippocampal CA1 region following transient global cerebral ischemia

Abstract

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Abstract

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