Published in:
01-06-2016 | Local-Regional Evaluation and Therapy (EP Mamounas, Section Editor)
New Developments in Assessing Risk of Local Recurrence in Patients with Ductal Carcinoma In Situ after Lumpectomy and Breast Radiation
Authors:
Nafisha Lalani, Sharon Nofech-Mozes, Eileen Rakovitch
Published in:
Current Breast Cancer Reports
|
Issue 2/2016
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Abstract
Ductal carcinoma in situ of the breast comprises nearly 25 % of all diagnoses of breast cancer. The current paradigm for management of DCIS consists of breast-conserving surgery followed by post-operative radiotherapy. The goal of the treatment of DCIS is to reduce the risk of local recurrence (and invasive local recurrence) to prevent the detrimental psychological impact of recurrence and minimize the need for additional treatment. A number of clinical, pathological, and molecular variables have been identified as predictive markers of recurrence and can be used to help risk stratify women with this diagnosis. We present here a review of current markers of recurrence, risk prediction tools, and future directions.