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Published in: Indian Journal of Surgery 3/2015

01-12-2015 | Review Article

Neutrophil Gelatinase Associated Lipocalin (NGAL) as a Biomarker. Does It Apply in Abdominal Aortic Aneurysms? A Review of Literature

Authors: Georgios Karaolanis, Demetrios Moris, Viktoria-Varvara Palla, Euridiki Karanikola, Chris Bakoyiannis, Sotirios Georgopoulos

Published in: Indian Journal of Surgery | Special Issue 3/2015

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Abstract

Neutrophil gelatinase associated lipocalin (NGAL) as a protein derived from neutrophils has recently been the field of investigation in a wide range of diseases (renal disease, coronary artery disease, etc). The MEDLINE/PubMed database was searched for publications with the medical subject heading “NGAL” and keywords “Abdominal aortic aneurysm (AAA),” “biomarker,” and “growth”. We restricted our search to date. In this review, we included 38 articles and abstracts that were accessible and available in English. An effort to further explain the role of NGAL within AAA has been made. NGAL seems to be a hopeful marker for the pathogenesis and the progression of abdominal aortic aneurysms (AAAs), which has significant morbidity and mortality rates.
Literature
1.
go back to reference Steinberg I, Stein HL (1966) Arterosclerotic abdominal aortic aneurysms. Report of 200 consecutive cases diagnosed by intravenous aortography. JAMA 195:1025CrossRefPubMed Steinberg I, Stein HL (1966) Arterosclerotic abdominal aortic aneurysms. Report of 200 consecutive cases diagnosed by intravenous aortography. JAMA 195:1025CrossRefPubMed
2.
go back to reference McGregor JC, Pollock JG, Anton HC (1975) The value of ultrasonography in the diagnosis of abdominal aortic aneurysm. Scott Med J 20:133–137PubMed McGregor JC, Pollock JG, Anton HC (1975) The value of ultrasonography in the diagnosis of abdominal aortic aneurysm. Scott Med J 20:133–137PubMed
3.
go back to reference Wanhainen A, Thermudo R, Ahlström H, Lind L, Johansson L (2008) Thoracic and abdominal aortic dimension in 70-years old men and women—a population-based whole-body MRI study. J Vasc Surg 47:504–512CrossRefPubMed Wanhainen A, Thermudo R, Ahlström H, Lind L, Johansson L (2008) Thoracic and abdominal aortic dimension in 70-years old men and women—a population-based whole-body MRI study. J Vasc Surg 47:504–512CrossRefPubMed
4.
go back to reference Sterpetti A, Schultz R, Feldhaus R, Cheng S, Peetz D (1987) Factors influencing enlargement rate of small abdominal aortic aneurysms. J Surg Res 43:211–219CrossRefPubMed Sterpetti A, Schultz R, Feldhaus R, Cheng S, Peetz D (1987) Factors influencing enlargement rate of small abdominal aortic aneurysms. J Surg Res 43:211–219CrossRefPubMed
5.
go back to reference Collin J, Walton J, Araujo L, Lindsell D (1988) Oxford screening programme for abdominal aortic aneurysm in men aged 65 to 74 years. Lancet 2:613–615CrossRefPubMed Collin J, Walton J, Araujo L, Lindsell D (1988) Oxford screening programme for abdominal aortic aneurysm in men aged 65 to 74 years. Lancet 2:613–615CrossRefPubMed
6.
go back to reference Sonesson B, Lanne T, Hansen F, Sandgren T (1994) Infrarenal aortic diameter in the healthy person. Eur J Vasc Surg 8:89–95CrossRefPubMed Sonesson B, Lanne T, Hansen F, Sandgren T (1994) Infrarenal aortic diameter in the healthy person. Eur J Vasc Surg 8:89–95CrossRefPubMed
7.
go back to reference Chang CK, Chuter TA, Niemann CU, Shlipak MG, Cohen MJ, Reilly LM et al (2009) Systemic inflammation, coagulopathy, and acute renal insufficiency following endovascular thoracoabdominal aortic aneurysm repair. J Vasc Surg 49(5):1140–1146CrossRefPubMedPubMedCentral Chang CK, Chuter TA, Niemann CU, Shlipak MG, Cohen MJ, Reilly LM et al (2009) Systemic inflammation, coagulopathy, and acute renal insufficiency following endovascular thoracoabdominal aortic aneurysm repair. J Vasc Surg 49(5):1140–1146CrossRefPubMedPubMedCentral
8.
9.
go back to reference Michel JB, Thaunat O, Houard X, Meilhac O, Caligiuri G, Nicoletti A (2007) Topological determinants and consequences of adventitial responses to arterial wall injury. Arterioscler Thromb Vasc Biol 27(6):1259–1268CrossRefPubMed Michel JB, Thaunat O, Houard X, Meilhac O, Caligiuri G, Nicoletti A (2007) Topological determinants and consequences of adventitial responses to arterial wall injury. Arterioscler Thromb Vasc Biol 27(6):1259–1268CrossRefPubMed
10.
11.
12.
go back to reference Akerstrom B, Flower DR, Salier JP (2000) Lipocalins: unity in diversity. Biochim Biophys Acta 1482:1–8CrossRefPubMed Akerstrom B, Flower DR, Salier JP (2000) Lipocalins: unity in diversity. Biochim Biophys Acta 1482:1–8CrossRefPubMed
13.
go back to reference Goetz DH, Holmes MA, Borregaard N et al (2002) The neutrophillipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol Cell 10:1033–1043CrossRefPubMed Goetz DH, Holmes MA, Borregaard N et al (2002) The neutrophillipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol Cell 10:1033–1043CrossRefPubMed
14.
go back to reference Kol A, Sukhova GK, Lichtman AH et al (1998) Chlamydial-heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression. Circulation 98:300–307CrossRefPubMed Kol A, Sukhova GK, Lichtman AH et al (1998) Chlamydial-heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression. Circulation 98:300–307CrossRefPubMed
15.
go back to reference Kjeldsen L, Cowland JB, Borregaard N (2000) Human neutrophil gelatinase-associated lipocalin and homologous proteins in rat and mouse. Biochim Biophys Acta 1482(1–2):272–283CrossRefPubMed Kjeldsen L, Cowland JB, Borregaard N (2000) Human neutrophil gelatinase-associated lipocalin and homologous proteins in rat and mouse. Biochim Biophys Acta 1482(1–2):272–283CrossRefPubMed
16.
go back to reference Devarajan P (2010) The promise of biomarkers for personalized renal cancer care. Kidney Int 77(9):755–757CrossRefPubMed Devarajan P (2010) The promise of biomarkers for personalized renal cancer care. Kidney Int 77(9):755–757CrossRefPubMed
17.
go back to reference Ramos-Mozo P, Madrigal-Matute J, Vega de Ceniga M, Blanco-Colio LM, Meilhac O, Feldman L et al (2012) Increased plasma levels of NGAL, a marker of neutrophil activation, in patients with abdominal aortic aneurysm. Atherosclerosis 220(2):552–556CrossRefPubMed Ramos-Mozo P, Madrigal-Matute J, Vega de Ceniga M, Blanco-Colio LM, Meilhac O, Feldman L et al (2012) Increased plasma levels of NGAL, a marker of neutrophil activation, in patients with abdominal aortic aneurysm. Atherosclerosis 220(2):552–556CrossRefPubMed
18.
go back to reference Elneihoum AM, Falke P, Hedblad B, Lindgärde F, Ohlsson K (1997) Leukocyte activation in atherosclerosis: correlation with risk factors. Atherosclerosis 131(1):79–84CrossRefPubMed Elneihoum AM, Falke P, Hedblad B, Lindgärde F, Ohlsson K (1997) Leukocyte activation in atherosclerosis: correlation with risk factors. Atherosclerosis 131(1):79–84CrossRefPubMed
19.
go back to reference Yndestad A, Landrø L, Ueland T, Dahl CP, Flo TH, Vinge LE et al (2009) Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure. Eur Heart J 30(10):1229–1236CrossRefPubMed Yndestad A, Landrø L, Ueland T, Dahl CP, Flo TH, Vinge LE et al (2009) Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure. Eur Heart J 30(10):1229–1236CrossRefPubMed
20.
go back to reference Giaginis C, Zira A, Katsargyris A, Klonaris C, Theocharis S (2010) Clinical implication of plasma neutrophil gelatinase-associated lipocalin (NGAL) concentrations in patients with advanced carotid atherosclerosis. Clin Chem Lab Med 48(7):1035–1041CrossRefPubMed Giaginis C, Zira A, Katsargyris A, Klonaris C, Theocharis S (2010) Clinical implication of plasma neutrophil gelatinase-associated lipocalin (NGAL) concentrations in patients with advanced carotid atherosclerosis. Clin Chem Lab Med 48(7):1035–1041CrossRefPubMed
21.
go back to reference Elneihoum AM, Falke P, Axelsson L, Lundberg E, Lindgärde F, Ohlsson K (1996) Leukocyte activation detected by increased plasma levels of inflammatory mediators in patients with ischemic cerebrovascular diseases. Stroke 27(10):1734–1738CrossRefPubMed Elneihoum AM, Falke P, Axelsson L, Lundberg E, Lindgärde F, Ohlsson K (1996) Leukocyte activation detected by increased plasma levels of inflammatory mediators in patients with ischemic cerebrovascular diseases. Stroke 27(10):1734–1738CrossRefPubMed
22.
go back to reference Anwaar I, Gottsäter A, Ohlsson K, Mattiasson I, Lindgärde F (1998) Increasing levels of leukocyte-derived inflammatory mediators in plasma and cAMP in platelets during follow-up after acute cerebral ischemia. Cerebrovasc Dis 8(6):310–317CrossRefPubMed Anwaar I, Gottsäter A, Ohlsson K, Mattiasson I, Lindgärde F (1998) Increasing levels of leukocyte-derived inflammatory mediators in plasma and cAMP in platelets during follow-up after acute cerebral ischemia. Cerebrovasc Dis 8(6):310–317CrossRefPubMed
23.
go back to reference Houard X, Ollivier V, Louedec L, Michel JB, Bäck M (2009) Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus. FASEB J 23(5):1376–1383CrossRefPubMed Houard X, Ollivier V, Louedec L, Michel JB, Bäck M (2009) Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus. FASEB J 23(5):1376–1383CrossRefPubMed
24.
go back to reference Eliason JL, Hannawa KK, Ailawadi G, Sinha I, Ford JW, Deogracias MP et al (2005) Neutrophil depletion inhibits experimental abdominal aortic aneurysm formation. Circulation 112(2):232–240CrossRefPubMed Eliason JL, Hannawa KK, Ailawadi G, Sinha I, Ford JW, Deogracias MP et al (2005) Neutrophil depletion inhibits experimental abdominal aortic aneurysm formation. Circulation 112(2):232–240CrossRefPubMed
25.
go back to reference Folkesson M, Kazi M, Zhu C, Silveira A, Hemdahl AL, Hamsten A et al (2007) Presence of NGAL/MMP-9 complexes in human abdominal aortic aneurysms. Thromb Haemost 98(2):427–433PubMed Folkesson M, Kazi M, Zhu C, Silveira A, Hemdahl AL, Hamsten A et al (2007) Presence of NGAL/MMP-9 complexes in human abdominal aortic aneurysms. Thromb Haemost 98(2):427–433PubMed
26.
go back to reference Yoshimura K, Aoki H, Ikeda Y, Furutani A, Hamano K, Matsuzaki M (2006) Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase in mice. Ann N Y Acad Sci 1085:74–81CrossRefPubMed Yoshimura K, Aoki H, Ikeda Y, Furutani A, Hamano K, Matsuzaki M (2006) Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase in mice. Ann N Y Acad Sci 1085:74–81CrossRefPubMed
27.
go back to reference Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK et al (2004) Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 432(7019):917–921CrossRefPubMed Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK et al (2004) Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 432(7019):917–921CrossRefPubMed
28.
go back to reference Delbosc S, Alsac JM, Journe C, Louedec L, Castier Y, Bonnaure-Mallet M et al (2011) Porphyromonas gingivalis participates in pathogenesis of human abdominal aortic aneurysm by neutrophil activation. Proof of concept in rats. PLoS One 6(4):e18679CrossRefPubMedPubMedCentral Delbosc S, Alsac JM, Journe C, Louedec L, Castier Y, Bonnaure-Mallet M et al (2011) Porphyromonas gingivalis participates in pathogenesis of human abdominal aortic aneurysm by neutrophil activation. Proof of concept in rats. PLoS One 6(4):e18679CrossRefPubMedPubMedCentral
29.
go back to reference Berger T, Togawa A, Duncan GS et al (2006) Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury. Proc Natl Acad Sci U S A 103:1834–1839CrossRefPubMedPubMedCentral Berger T, Togawa A, Duncan GS et al (2006) Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury. Proc Natl Acad Sci U S A 103:1834–1839CrossRefPubMedPubMedCentral
30.
go back to reference Juvonen T, Biancari F, Juvonen J (2002) Chlamydia pneumonia and aortic aneurysms. Scand Cardiovasc J 36:327–328CrossRefPubMed Juvonen T, Biancari F, Juvonen J (2002) Chlamydia pneumonia and aortic aneurysms. Scand Cardiovasc J 36:327–328CrossRefPubMed
31.
go back to reference Swedenborg J, Eriksson P (2006) The intraluminal thrombus as a source of proteolytic activity. Ann N Y Acad Sci 1085:133–138CrossRefPubMed Swedenborg J, Eriksson P (2006) The intraluminal thrombus as a source of proteolytic activity. Ann N Y Acad Sci 1085:133–138CrossRefPubMed
32.
go back to reference Houard X, Touat Z, Ollivier V, Louedec L, Philippe M, Sebbag U et al (2009) Mediators of neutrophil recruitment in human abdominal aortic aneurysms. Cardiovasc Res 82(3):532–541CrossRefPubMedPubMedCentral Houard X, Touat Z, Ollivier V, Louedec L, Philippe M, Sebbag U et al (2009) Mediators of neutrophil recruitment in human abdominal aortic aneurysms. Cardiovasc Res 82(3):532–541CrossRefPubMedPubMedCentral
33.
go back to reference Grigoryev DN, Liu M, Hassoun HT et al (2008) The local and systemic inflammatory transcriptome after acute kidney injury. J Am Soc Nephrol 19:547–558CrossRefPubMedPubMedCentral Grigoryev DN, Liu M, Hassoun HT et al (2008) The local and systemic inflammatory transcriptome after acute kidney injury. J Am Soc Nephrol 19:547–558CrossRefPubMedPubMedCentral
34.
go back to reference Kokot M, Biolik G, Ziaja D et al (2012) Acute kidney injury after abdominal aortic aneurysm surgery: detailed assessment of early effects using novel markers. Pol Arch Med Wewn 122(7–8):353–360PubMed Kokot M, Biolik G, Ziaja D et al (2012) Acute kidney injury after abdominal aortic aneurysm surgery: detailed assessment of early effects using novel markers. Pol Arch Med Wewn 122(7–8):353–360PubMed
35.
go back to reference Lacquaniti A, Giardina M, Lucisano S, Messina R, Buemi A, Risitano CD et al (2014) Neutrophil gelatinase-associated lipocalin (NGAL) and endothelial progenitor cells (EPCS) evaluation in aortic aneurysm repair. Curr Vasc Pharmacol 11(6):1001–1010CrossRef Lacquaniti A, Giardina M, Lucisano S, Messina R, Buemi A, Risitano CD et al (2014) Neutrophil gelatinase-associated lipocalin (NGAL) and endothelial progenitor cells (EPCS) evaluation in aortic aneurysm repair. Curr Vasc Pharmacol 11(6):1001–1010CrossRef
36.
go back to reference Speelman L, Schurink GW, Bosboom EM, Buth J, Breeuwer M, van de Vosse FN, Jacobs MH (2010) The mechanical role of thrombus on the growth rate of an abdominal aortic aneurysm. J Vasc Surg 51(1):19–26CrossRefPubMed Speelman L, Schurink GW, Bosboom EM, Buth J, Breeuwer M, van de Vosse FN, Jacobs MH (2010) The mechanical role of thrombus on the growth rate of an abdominal aortic aneurysm. J Vasc Surg 51(1):19–26CrossRefPubMed
37.
go back to reference Speelman L, Hellenthal FA, Pulinx B, Bosboom EM, Breeuwer M, van Sambeek MR et al (2010) The influence of wall stress on AAA growth and biomarkers. Eur J Vasc Endovasc Surg 39(4):410–416CrossRefPubMed Speelman L, Hellenthal FA, Pulinx B, Bosboom EM, Breeuwer M, van Sambeek MR et al (2010) The influence of wall stress on AAA growth and biomarkers. Eur J Vasc Endovasc Surg 39(4):410–416CrossRefPubMed
Metadata
Title
Neutrophil Gelatinase Associated Lipocalin (NGAL) as a Biomarker. Does It Apply in Abdominal Aortic Aneurysms? A Review of Literature
Authors
Georgios Karaolanis
Demetrios Moris
Viktoria-Varvara Palla
Euridiki Karanikola
Chris Bakoyiannis
Sotirios Georgopoulos
Publication date
01-12-2015
Publisher
Springer India
Published in
Indian Journal of Surgery / Issue Special Issue 3/2015
Print ISSN: 0972-2068
Electronic ISSN: 0973-9793
DOI
https://doi.org/10.1007/s12262-014-1099-1

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