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BMC Musculoskeletal Disorders
Published in: BMC Musculoskeletal Disorders 1/2021

Open Access 01-12-2021 | Neurotomy | Research article

Influence of IGF-I serum concentration on muscular regeneration capacity in patients with sarcopenia

Authors: Stefanie Jarmusch, Lisa Baber, Martin Bidlingmaier, Uta Ferrari, Fabian Hofmeister, Stefan Hintze, Stefan Mehaffey, Peter Meinke, Carl Neuerburg, Benedikt Schoser, Fabiana Tanganelli, Michael Drey

Published in: BMC Musculoskeletal Disorders | Issue 1/2021

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Abstract

Background

Previous research has described a neuroprotective effect of IGF-I, supporting neuronal survival, axon growth and proliferation of muscle cells. Therefore, the association between IGF-I concentration, muscle histology and electrophysiological markers in a cohort of patients with sarcopenia dares investigation.

Methods

Measurement of serum concentrations of IGF-I and binding partners, electromyographic measurements with the MUNIX (Motor Unit Number Index) method and muscle biopsies were performed in 31 patients with acute hip fracture older age 60 years. Molecular markers for denervation (neural cell adhesion molecule NCAM) and proliferation markers (Ki67) were assessed by immunofluorescence staining of muscle biopsy tissue. Skeletal muscle mass by bioelectrical impedance analysis and hand-grip strength were measured to assess sarcopenia status according to EWGSOP2 criteria.

Results

Thirty-one patients (20 women) with a mean age of 80.6 ± 7.4 years were included. Concentrations of IGF-I and its binding partners were significantly associated with sarcopenia (ß = − 0.360; p = 0.047) and MUNIX (ß = 0.512; p = 0.005). Further, expression of NCAM (ß = 0.380; p = 0.039) and Ki67 (ß = 0.424; p = 0.022) showed significant associations to IGF-I concentrations.

Conclusions

The findings suggest a pathogenetic role of IGF-I in sarcopenia based on muscle denervation.
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Metadata
Title
Influence of IGF-I serum concentration on muscular regeneration capacity in patients with sarcopenia
Authors
Stefanie Jarmusch
Lisa Baber
Martin Bidlingmaier
Uta Ferrari
Fabian Hofmeister
Stefan Hintze
Stefan Mehaffey
Peter Meinke
Carl Neuerburg
Benedikt Schoser
Fabiana Tanganelli
Michael Drey
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2021
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/s12891-021-04699-3

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