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01-12-2020 | Neurotomy | Editorial

Ablating the renal nerves to treat heart failure with reduced ejection fraction: another treatment option in a crowded space?

Author: Murray Esler

Published in: Clinical Autonomic Research | Issue 6/2020

Excerpt

Howard Levin and Mark Gelfand first showed the feasibility of catheter-based renal denervation for cardiovascular diseases almost 20 years ago [US provisional patents 60/370 190 (April 2002), 60/415 575 (October 2002) and 60/442 970 (January 2003)]. Sympathetic nerves pass to the human kidneys via the outer wall and peri-adventitial region of the renal arteries, within reach of ablative energy delivered from the artery lumen. The renal sympathetic outflow is activated in hypertension, heart failure, obesity and hepatic cirrhosis [1], so that the renal sympathetic nerves came to be seen as a logical, potential target in these disorders. Levin and Gelfand initially envisioned an application of catheter-based renal denervation in heart failure. …

Esler M, Jennings G, Korner P, Willett I, Dudley F, Hasking G et al (1988) The assessment of human sympathetic nervous system activity from measurements of norepinephrine turnover. Hypertension 11:3–20CrossRef

Krum H, Schlaich M, Whitbourn R, Sobotka P, Sadowski J, Bartus K et al (2009) Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet 373:1275–1281CrossRef

Symplicity HTN-2 Investigators (CI Esler M) (2010) Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomized controlled trial. Lancet 376:1903–1909CrossRef

Lian Z, Shi-Ran Yu, Song J-X, Lee C-Y, Li S-F, Cui Y-X et al (2020) Efficacy and safety of catheter-based renal denervation for heart failure with reduced ejection fraction: a systematic review. Clin Autonom Res. https://doi.org/10.1007/s10286-020-00716-yCrossRef

Fukuta H, Goto T, Wakami K, Ohte N (2017) Effects of catheter-based renal denervation on heart failure with reduced ejection fraction: a systematic review and meta-analysis. Heart Fail Rev 22:657–664CrossRef

Moher D, Liberati A, Tetzlaff J (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Rev 151:264–269CrossRef

Kaye DM, Lefkovits J, Jennings GL, Bergin P, Broughton A, Esler MD (1995) Adverse consequences of high sympathetic nervous activity in the failing human heart. J Am Coll Cardiol 26:1257–1263CrossRef

Di Bona GF (2000) Nervous kidney. Interaction between renal sympathetic nerves and the renin-angiotensin system in the control of renal function. Hypertension 36:1083–1088CrossRef

Petersson M, Friberg P, Eisenhofer G, Lambert G, Rundqvist B (2005) Long-term outcome in relation to renal sympathetic activity in patients with chronic heart failure. Eur Heart J 26:906–913CrossRef

10.

Hering D, Lambert EA, Marusic P, Walton AS, Krum H, Lambert GW et al (2013) Substantial reduction in single sympathetic nerve firing after renal denervation in patients with resistant hypertension. Hypertension 61:457–464CrossRef

Title: Ablating the renal nerves to treat heart failure with reduced ejection fraction: another treatment option in a crowded space?
Author: Murray Esler
Publication date: 01-12-2020
Publisher: Springer Berlin Heidelberg
Keywords: Neurotomy
Heart Failure
Published in: Clinical Autonomic Research / Issue 6/2020
Print ISSN: 0959-9851
Electronic ISSN: 1619-1560
DOI: https://doi.org/10.1007/s10286-020-00741-x

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Ablating the renal nerves to treat heart failure with reduced ejection fraction: another treatment option in a crowded space?

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