Issue 4/2005
Drug Discovery for Disorders of the Central Nervous System
Content (13 Articles)
Editorial
Drug discovery for disorders of the central nervous system
Menelas N. Pangalos, Christopher C. Gallen
Medicinal chemical properties of successful central nervous system drugs
Hassan Pajouhesh, George R. Lenz
Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery
Mohammad S. Alavijeh, Mansoor Chishty, M. Zeeshan Qaiser, Alan M. Palmer
The quest for market exclusivity in biotechnology: Navigating the patent minefield
Judge David M. Gersten
Developing therapeutics for schizophrenia and other psychotic disorders
Gerard Marek, Kalpana Merchant
Innovative approaches for the development of antidepressant drugs: Current and future strategies
Lee E. Schechter, Robert H. Ring, Chad E. Beyer, Zoë A. Hughes, Xavier Khawaja, Jessica E. Malberg, Sharon Rosenzweig-Lipson
Current concepts in therapeutic strategies targeting cognitive decline and disease modification in Alzheimer’s disease
J. Steven Jacobsen, Peter Reinhart, Menelas N. Pangalos
New prospects and strategies for drug target discovery in neurodegenerative disorders
Brian S. Hilbush, John H. Morrison, Warren G. Young, J. Gregor Sutcliffe, Floyd E. Bloom
Challenges in the development of novel treatment strategies for neuropathic pain
Michael H. Ossipov, Frank Porreca
Central nervous system drug development: An integrative biomarker approach toward individualized medicine
B. Gomez-Mancilla, E. Marrer, J. Kehren, A. Kinnunen, G. Imbert, R. Hillebrand, M. Bergström, M. E. Schmidt