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Neurological Sciences
Published in: Neurological Sciences 5/2016

01-05-2016 | Original Article

Neuroprotective effect of lignans extracted from Eucommia ulmoides Oliv. on glaucoma-related neurodegeneration

Authors: Chao-Peng Li, Gui-Zhen Qiu, Ban Liu, Jin-Long Chen, Hai-Tao Fu

Published in: Neurological Sciences | Issue 5/2016

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Abstract

Glaucoma is a progressive neurodegenerative disease, characterized by retinal ganglion cells (RGCs) and axon degeneration. The development of neuroprotective drug is required for improving the efficiency of glaucoma treatment. Eucommia ulmoides Oliv. has been used as a source of traditional medicine and as a beneficial health food. Lignans is one of the main bioactive components of Eucommia ulmoides. Here, we show that lignans protects RGCs against oxidative stress-induced injury in vitro. Moreover, lignans exerts neuroprotective effect on glaucoma-associated optic neuropathy in glaucomatous rats. Lignans treatment could improve oxidative stress response in RGCs and retinas of glaucomatous rats. Lignans plays an anti-oxidative stress role via the activation of AMPK signaling. This study provides evidence that lignans possesses protective effect on glaucoma-associated optic neuropathy. Lignans might be an alternative for the prevention and treatment of glaucomatous neurodegeneration.
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Metadata
Title
Neuroprotective effect of lignans extracted from Eucommia ulmoides Oliv. on glaucoma-related neurodegeneration
Authors
Chao-Peng Li
Gui-Zhen Qiu
Ban Liu
Jin-Long Chen
Hai-Tao Fu
Publication date
01-05-2016
Publisher
Springer Milan
Published in
Neurological Sciences / Issue 5/2016
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-016-2491-3

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