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Knee Surgery, Sports Traumatology, Arthroscopy

Published in:

01-03-2019 | Experimental Study

Neuropeptides: important regulators of joint homeostasis

Authors: Birgitta Gatenholm, Mats Brittberg

Published in: Knee Surgery, Sports Traumatology, Arthroscopy | Issue 3/2019

Abstract

Purpose

This review explores the mechanisms of joint pain with a special focus on the role of neuropeptides in pain transmission and their potential role in the progression of joint degeneration as seen in osteoarthritis.

Methods

A literature search was performed on papers published between January 1990 and September 2017 using the Web of Science Core Collection, MEDLINE and Scopus databases.

Results

What is seen in the subchondral bone and synovia is mirrored in the central nervous system (CNS). Substance P, calcitonin gene-related peptide, vasoactive intestinal peptide and neuropeptide Y are the major peptides involved both in the generation of pain as well as reducing pain post-joint trauma. The interplay between them and other neuropeptides and cytokines influence how noxious stimuli are transduced, transmitted and modulated for a final pain perception as part of a complex cascade of events. There is a close interaction between the different components in the joint that together cross-talk to adapt to load and catabolic factors during injury and inflammation.

Conclusion

The articular joint should be seen as an organ where local joint pain development and maintenance is influenced by interplay between the local transmitters in the joints as well as their dependence on the CNS. A slow-release cocktail of mixed antibodies targeted against neuropeptides and receptor blockers/stimulators involved in the events of early joint pain or any inflammatory joint disease is a future treatment target.

Level of evidence

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Title: Neuropeptides: important regulators of joint homeostasis
Authors: Birgitta Gatenholm
Mats Brittberg
Publication date: 01-03-2019
Publisher: Springer Berlin Heidelberg
Published in: Knee Surgery, Sports Traumatology, Arthroscopy / Issue 3/2019
Print ISSN: 0942-2056
Electronic ISSN: 1433-7347
DOI: https://doi.org/10.1007/s00167-018-5074-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Neuropeptides: important regulators of joint homeostasis

Abstract

Purpose

Methods

Results

Conclusion

Level of evidence

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

Level of evidence

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