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Journal of Neural Transmission
Published in: Journal of Neural Transmission 10/2012

01-10-2012 | Basic Neurosciences, Genetics and Immunology - Review article

Neuroimmunomodulation in unipolar depression: a focus on chronobiology and chronotherapeutics

Authors: Harris Eyre, Bernhard T. Baune

Published in: Journal of Neural Transmission | Issue 10/2012

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Abstract

The rising burden of unipolar depression along with its often related sleep disturbances, as well as increasing rates of sleep restriction in modern society, make the search for an extended understanding of the aetiology and pathophysiology of depression necessary. Accumulating evidence suggests an important role for the immune system in mediating disrupted neurobiological and chronobiological processes in depression. This review aims to provide an overview of the neuroimmunomodulatory processes involved with depression and antidepressant treatments with a special focus on chronobiology, chronotherapeutics and the emerging field of immune-circadian bi-directional crosstalk. Increasing evidence suggests that chronobiological disruption can mediate immune changes in depression, and likewise, immune processes can mediate chronobiological disruption. This may suggest a bi-directional relationship in immune-circadian crosstalk. Furthermore, given the immunomodulatory effects of antidepressants and chronotherapeutics, as well as their associated beneficial effects on circadian disturbance, we—and others—suggest that these therapeutic agents may exert their chronobiotic effects partially via the neuroimmune system. Further research is required to better elucidate the mechanisms of immune involvement in the chronobiology of depression.
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Metadata
Title
Neuroimmunomodulation in unipolar depression: a focus on chronobiology and chronotherapeutics
Authors
Harris Eyre
Bernhard T. Baune
Publication date
01-10-2012
Publisher
Springer Vienna
Published in
Journal of Neural Transmission / Issue 10/2012
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-012-0819-6

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