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01-06-2013

Neuroimaging Methods for Adolescent Substance Use Disorder Prevention Science

Authors: D. B. Clark, T. Chung, S. Pajtek, Z. Zhai, E. Long, B. Hasler

Published in: Prevention Science | Issue 3/2013

Abstract

Magnetic resonance imaging (MRI) methods safely provide in vivo indicators of cerebral macrostructure, microstructure, and activation that can be examined in relation to substance use disorder (SUD) risks and effects. This article will provide an overview of MRI approaches, including volumetric measures, diffusion tensor imaging, and functional MRI, that have been applied to studies of adolescent neuromaturation in relationship to risk phenotypes and adolescent SUD. To illustrate these applications, examples of research findings will be presented. MRI indicators have demonstrated that neurobiological maturation continues throughout adolescence. MRI research has suggested that variations in neurobiological maturation may contribute to SUD risk, and that substance use adversely influences adolescent brain development. Directly measured neurobiological variables may be viable preventive intervention targets and outcome indicators. Further research is needed to provide definitive findings on neurodevelopmental immaturity as an SUD risk and to determine the directions such observations suggest for advancing prevention science.

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Title: Neuroimaging Methods for Adolescent Substance Use Disorder Prevention Science
Authors: D. B. Clark
T. Chung
S. Pajtek
Z. Zhai
E. Long
B. Hasler
Publication date: 01-06-2013
Publisher: Springer US
Published in: Prevention Science / Issue 3/2013
Print ISSN: 1389-4986
Electronic ISSN: 1573-6695
DOI: https://doi.org/10.1007/s11121-012-0323-0

At a glance: The STEP trials

Springer Medicine

Neuroimaging Methods for Adolescent Substance Use Disorder Prevention Science

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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