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01-12-2008 | Review

Neuroglial heterotopia causing neonatal airway obstruction: presentation, management, and literature review

Authors: Omar F. Husein, Meredith Collins, D. Richard Kang

Published in: European Journal of Pediatrics | Issue 12/2008

Abstract

Neuroglial heterotopias are rare congenital masses that are thought to represent encephaloceles that become sequestered on the extracranial side of the skull base. Although most often adjacent to bony skull base defects, they lack communication to the subarachnoid space. They contain mature neuroglial tissue and specialized central nervous system elements, such as a functioning choroid plexus. A case is presented of neonatal airway obstruction due to neuroglial heterotopia in the nasopharynx. The patient’s clinical course and treatment are discussed, along with their radiology and histology. The relevant scientific literature is reviewed.

Al-Ammar AY, Al Noumas HS, Alqahtani M (2006) A midline nasopharyngeal heterotopic neuroglial tissue. J Laryngol Otol 120:E25. doi:10.1017/S0022215106002040 PubMedCrossRef

Amin A, Monabati A, Kumar PV, Hashemi SB (2005) Nasal glioma (neuroglial heterotopia) mimicking an astrocytoma: case report. Ear Nose Throat J 84:657–658PubMed

Anjaneyulu C, Deka RC (2004) Heterotopic neuroglial tissue in hard palate. Indian J Pediatr 71:451–452. doi:10.1007/BF02725640 PubMedCrossRef

April MM, Seymour BT, Duboys E, Egnor M, Braun A, Katz AE (1994) Massive cystic heterotopic brain tissue. Int J Pediatr Otorhinolaryngol 28:235–239. doi:10.1016/0165-5876(94)90017-5 PubMedCrossRef

Behar PM, Muller S, Gerber ME, Todd NW (2001) Heterotopic neuroglial tissue causing airway obstruction in the newborn. Arch Otolaryngol Head Neck Surg 127:997–1002PubMed

Buccoliero AM, Caldarella A, Noccioli B, Fiorini P, Taddei A, Taddei GL (2002) Brain heterotopia in pharyngeal region. A morphological and immunohistochemical study. Pathol Res Pract 198:59–63. doi:10.1078/0344-0338-00186 PubMedCrossRef

Carrillo-Farga J, Gutierrez-Palomera G, Mandujano M (1988) Neuroglial choristoma of the pharynx. Ear Nose Throat J 67:579–580; 582–583PubMed

Cerdá-Nicolás M, Sanchez Fernandez de Sevilla C, Lopez-Ginés C, Peydro-Olaya A, Llombart-Bosch A (2002) Nasal glioma or nasal glial heterotopia? Morphological, immunohistochemical and ultrastructural study of two cases. Clin Neuropathol 21:66–71PubMed

Clarós P, Bandos R, Clarós A Jr, Gilea I, Clarós A, Real M (1998) Nasal gliomas: main features, management and report of five cases. Int J Pediatr Otorhinolaryngol 46:15–20. doi:10.1016/S0165-5876(98)00114-1 PubMedCrossRef

10.

Cohen AH, Abt AB (1970) An unusual cause of neonatal respiratory obstruction: heterotopic pharyngeal brain tissue. J Pediatr 76:119–122. doi:10.1016/S0022-3476(70)80141-X PubMedCrossRef

11.

Dinwiddie R (2004) Congenital upper airway obstruction. Paediatr Respir Rev 5:17–24. doi:10.1016/j.prrv.2003.10.001 PubMedCrossRef

12.

Forte V, Friedberg J, Thorner P, Park A (1996) Heterotopic brain in the parapharyngeal space. Int J Pediatr Otorhinolaryngol 37:253–260. doi:10.1016/0165-5876(96)01401-2 PubMedCrossRef

13.

Madjidi A, Couley G (1993) Heterotopic neuroglial tissue of the face. Report of six cases and review of the literature. Oral Surg Oral Med Oral Pathol 76:284–288. doi:10.1016/0030-4220(93)90254-2 PubMedCrossRef

14.

Mahapatra AK, Agrawal D (2006) Anterior encephaloceles: a series of 103 cases over 32 years. J Clin Neurosci 13:536–539. doi:10.1016/j.jocn.2005.05.016 PubMedCrossRef

15.

Mylanus EA, Marres HA, Vlietman J, Kollée LA, Freihofer HP, Thijssen HO et al (1999) Transalar sphenoidal encephalocele and respiratory distress in a neonate: a case report. Pediatrics 103:E12. doi:10.1542/peds.103.1.e12 PubMedCrossRef

16.

Patterson K, Kapur S, Chandra RS (1986) “Nasal gliomas” and related brain heterotopias: a pathologist’s perspective. Pediatr Pathol 5:353–362. doi:10.3109/15513818609068861 PubMedCrossRef

17.

Roh JL (2004) Transoral endoscopic resection of a nasopharyngeal hairy polyp. Int J Pediatr Otorhinolaryngol 68:1087–1090. doi:10.1016/j.ijporl.2004.03.005 PubMedCrossRef

18.

Ruff T, Diaz JA (1986) Heterotopic brain in the nasopharynx. Otolaryngol Head Neck Surg 94:254–256PubMed

19.

Seibert RW, Seibert JJ, Jimenez JF, Angtuaco EJ (1984) Nasopharyngeal brain heterotopia—a cause of upper airway obstruction in infancy. Laryngoscope 94:818–819PubMed

20.

Sinn DP, Wessberg GA, Coln CD, Weinberg AG, Sklar FH (1981) Neonatal asphyxia secondary to Robin complex and neuroglia heterotopia of nasopharynx. Oral Surg Oral Med Oral Pathol 52:137–141. doi:10.1016/0030-4220(81)90309-1 PubMedCrossRef

21.

Uemura T, Yoshikawa A, Onizuka T, Hayashi T (1999) Heterotopic nasopharyngeal brain tissue associated with cleft palate. Cleft Palate Craniofac J 36:248–251. doi:10.1597/1545-1569(1999)036<0248:HNBTAW>2.3.CO;2 PubMedCrossRef

22.

Van Den Abbeele T, Elmaleh M, Herman P, François M, Narcy P (1999) Transnasal endoscopic repair of congenital defects of the skull base in children. Arch Otolaryngol Head Neck Surg 125:580–584

23.

Woodworth BA, Schlosser RJ, Faust RA, Bolger WE (2004) Evolutions in the management of congenital intranasal skull base defects. Arch Otolaryngol Head Neck Surg 130:1283–1288. doi:10.1001/archotol.130.11.1283 PubMedCrossRef

24.

Yeoh GP, Bale PM, de Silva M (1989) Nasal cerebral heterotopia: the so-called nasal glioma or sequestered encephalocele and its variants. Pediatr Pathol 9:531–549. doi:10.3109/15513818909026912 PubMedCrossRef

25.

Zarem HA, Gray GF Jr, Morehead D, Edgerton MT (1967) Heterotopic brain in the nasopharynx and soft palate: report of two cases. Surgery 61:483–486PubMed

Title: Neuroglial heterotopia causing neonatal airway obstruction: presentation, management, and literature review
Authors: Omar F. Husein
Meredith Collins
D. Richard Kang
Publication date: 01-12-2008
Publisher: Springer-Verlag
Published in: European Journal of Pediatrics / Issue 12/2008
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-008-0810-2

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Neuroglial heterotopia causing neonatal airway obstruction: presentation, management, and literature review

Abstract

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Abstract

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